Skin Rash and Interstitial Pneumonia Can Be a Fatal Combination: A Rare Case of Anti-Melanoma Differentiation-Associated Gene 5 (MDA5)-Associated Interstitial Lung Disease

We report the case of a 62-year-old male patient fully vaccinated for COVID-19, admitted to our emergency room for persistent fever associated with exertional dyspnoea, skin lesions, diffuse myalgias and arthralgias not responsive to broad-spectrum antibiotic and antiviral therapy, who developed a r...

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Autores principales:	Giorgia Borio, Chiara Terracciano, Federico Buttafava, Andrea Vercelli, Laura Pagani, Chiara Zanzani, Alessandra Manicardi, Andrea Magnacavallo, Erika Poggiali
Formato:	article
Lenguaje:	EN
Publicado:	SMC MEDIA SRL 2021
Materias:	mda5-associated dermatomyositis mda5-associated interstitial lung disease interstitial pneumonia dyspnoea Medicine R
Acceso en línea:	https://doaj.org/article/d1b412bf6a4a4c31874886b768fbafe7
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spelling	oai:doaj.org-article:d1b412bf6a4a4c31874886b768fbafe72021-11-09T11:21:26ZSkin Rash and Interstitial Pneumonia Can Be a Fatal Combination: A Rare Case of Anti-Melanoma Differentiation-Associated Gene 5 (MDA5)-Associated Interstitial Lung Disease2284-259410.12890/2021_002860https://doaj.org/article/d1b412bf6a4a4c31874886b768fbafe72021-10-01T00:00:00Zhttps://www.ejcrim.com/index.php/EJCRIM/article/view/2860https://doaj.org/toc/2284-2594We report the case of a 62-year-old male patient fully vaccinated for COVID-19, admitted to our emergency room for persistent fever associated with exertional dyspnoea, skin lesions, diffuse myalgias and arthralgias not responsive to broad-spectrum antibiotic and antiviral therapy, who developed a rapidly progressive refractory to treatment interstitial lung disease due to anti-melanoma differentiation-associated gene 5 (MDA5) antibodies, that required mechanical ventilation and ECMO. Here, we highlight the importance of always considering alternative diagnoses, i.e. viral and autoimmune diseases, including anti-MDA5 antibody screening, when dealing with patients with a skin rash, seronegative polyarthralgias and interstitial pneumonia, or acute respiratory distress syndrome of unknown origin.Giorgia BorioChiara TerraccianoFederico ButtafavaAndrea VercelliLaura PaganiChiara ZanzaniAlessandra ManicardiAndrea MagnacavalloErika PoggialiSMC MEDIA SRLarticlemda5-associated dermatomyositismda5-associated interstitial lung diseaseinterstitial pneumoniadyspnoeaMedicineRENEuropean Journal of Case Reports in Internal Medicine (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mda5-associated dermatomyositis mda5-associated interstitial lung disease interstitial pneumonia dyspnoea Medicine R
spellingShingle	mda5-associated dermatomyositis mda5-associated interstitial lung disease interstitial pneumonia dyspnoea Medicine R Giorgia Borio Chiara Terracciano Federico Buttafava Andrea Vercelli Laura Pagani Chiara Zanzani Alessandra Manicardi Andrea Magnacavallo Erika Poggiali Skin Rash and Interstitial Pneumonia Can Be a Fatal Combination: A Rare Case of Anti-Melanoma Differentiation-Associated Gene 5 (MDA5)-Associated Interstitial Lung Disease
description	We report the case of a 62-year-old male patient fully vaccinated for COVID-19, admitted to our emergency room for persistent fever associated with exertional dyspnoea, skin lesions, diffuse myalgias and arthralgias not responsive to broad-spectrum antibiotic and antiviral therapy, who developed a rapidly progressive refractory to treatment interstitial lung disease due to anti-melanoma differentiation-associated gene 5 (MDA5) antibodies, that required mechanical ventilation and ECMO. Here, we highlight the importance of always considering alternative diagnoses, i.e. viral and autoimmune diseases, including anti-MDA5 antibody screening, when dealing with patients with a skin rash, seronegative polyarthralgias and interstitial pneumonia, or acute respiratory distress syndrome of unknown origin.
format	article
author	Giorgia Borio Chiara Terracciano Federico Buttafava Andrea Vercelli Laura Pagani Chiara Zanzani Alessandra Manicardi Andrea Magnacavallo Erika Poggiali
author_facet	Giorgia Borio Chiara Terracciano Federico Buttafava Andrea Vercelli Laura Pagani Chiara Zanzani Alessandra Manicardi Andrea Magnacavallo Erika Poggiali
author_sort	Giorgia Borio
title	Skin Rash and Interstitial Pneumonia Can Be a Fatal Combination: A Rare Case of Anti-Melanoma Differentiation-Associated Gene 5 (MDA5)-Associated Interstitial Lung Disease
title_short	Skin Rash and Interstitial Pneumonia Can Be a Fatal Combination: A Rare Case of Anti-Melanoma Differentiation-Associated Gene 5 (MDA5)-Associated Interstitial Lung Disease
title_full	Skin Rash and Interstitial Pneumonia Can Be a Fatal Combination: A Rare Case of Anti-Melanoma Differentiation-Associated Gene 5 (MDA5)-Associated Interstitial Lung Disease
title_fullStr	Skin Rash and Interstitial Pneumonia Can Be a Fatal Combination: A Rare Case of Anti-Melanoma Differentiation-Associated Gene 5 (MDA5)-Associated Interstitial Lung Disease
title_full_unstemmed	Skin Rash and Interstitial Pneumonia Can Be a Fatal Combination: A Rare Case of Anti-Melanoma Differentiation-Associated Gene 5 (MDA5)-Associated Interstitial Lung Disease
title_sort	skin rash and interstitial pneumonia can be a fatal combination: a rare case of anti-melanoma differentiation-associated gene 5 (mda5)-associated interstitial lung disease
publisher	SMC MEDIA SRL
publishDate	2021
url	https://doaj.org/article/d1b412bf6a4a4c31874886b768fbafe7
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Skin Rash and Interstitial Pneumonia Can Be a Fatal Combination: A Rare Case of Anti-Melanoma Differentiation-Associated Gene 5 (MDA5)-Associated Interstitial Lung Disease

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