“One-stop shop” spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology
Kaid Darwiche,1 Paul Zarogoulidis,1,2 Leslie Krauss,3 Filiz Oezkan,1 Robert Fred Henry Walter,1,4 Robert Werner,4 Dirk Theegarten,4 Leonidas Sakkas,5 Antonios Sakkas,5 Wolfgang Hohenforst-Scmidt,6 Konstantinos Zarogoulidis,1 Lutz Freitag11Department of Interventional Pneumology, Ruhrlandklinik, West...
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/d1b801badc4f4265a4404f06bf95b2aa |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:d1b801badc4f4265a4404f06bf95b2aa |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:d1b801badc4f4265a4404f06bf95b2aa2021-12-02T08:07:35Z“One-stop shop” spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology1176-91141178-2013https://doaj.org/article/d1b801badc4f4265a4404f06bf95b2aa2013-11-01T00:00:00Zhttp://www.dovepress.com/ldquoone-stop-shoprdquo-spectral-imaging-for-rapid-on-site-diagnosis-o-a15069https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Kaid Darwiche,1 Paul Zarogoulidis,1,2 Leslie Krauss,3 Filiz Oezkan,1 Robert Fred Henry Walter,1,4 Robert Werner,4 Dirk Theegarten,4 Leonidas Sakkas,5 Antonios Sakkas,5 Wolfgang Hohenforst-Scmidt,6 Konstantinos Zarogoulidis,1 Lutz Freitag11Department of Interventional Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany; 2Pulmonary Department, Oncology Unit, G Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 3CytoViva, Inc, Auburn, AL, USA; 4Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany; 5Pathology Department, G Papanikolaou General Hospital, Thessaloniki, Greece; 6II Medical Department, Coburg Regional Clinic, University of Wuerzburg, Coburg, GermanyBackground: There are currently many techniques and devices available for the diagnosis of lung cancer. However, rapid on-site diagnosis is essential for early-stage lung cancer, and in the current work we investigated a new diagnostic illumination nanotechnology.Methods: Tissue samples were obtained from lymph nodes, cancerous tissue, and abnormal intrapulmonary lesions at our interventional pulmonary suites. The following diagnostic techniques were used to obtain the samples: endobronchial ultrasound bronchoscopy; flexible bronchoscopy; and rigid bronchoscopy. Flexible and rigid forceps were used because several of the patients were intubated using a rigid bronchoscope. In total, 30 tissue specimens from 30 patients were prepared. CytoViva® illumination nanotechnology was subsequently applied to each of the biopsy tissue slides.Results: A spectral library was created for adenocarcinoma, epidermal growth factor receptor mutation-positive adenocarcinoma, squamous cell carcinoma, usual interstitial pneumonitis, nonspecific interstitial pneumonitis, typical carcinoid tumor, sarcoidosis, idiopathic pulmonary fibrosis, small cell neuroendocrine carcinoma, thymoma, epithelioid and sarcomatoid mesothelioma, cryptogenic organizing pneumonia, malt cell lymphoma, and Wegener's granulomatosis.Conclusion: The CytoViva software, once it had created a specific spectral library for each entity, was able to identify the same disease again in subsequent paired sets of slides of the same disease. Further evaluation of this technique could make this illumination nanotechnology an efficient rapid on-site diagnostic tool.Keywords: lung cancer, endobronchial ultrasound, spectral imaging, diagnosisDarwiche KZarogoulidis PKrauss LOezkan FWalter RFHWerner RTheegarten DSakkas LSakkas AHohenforst-Schmidt WZarogoulidis KFreitag LDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 4533-4542 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine (General) R5-920 |
| spellingShingle |
Medicine (General) R5-920 Darwiche K Zarogoulidis P Krauss L Oezkan F Walter RFH Werner R Theegarten D Sakkas L Sakkas A Hohenforst-Schmidt W Zarogoulidis K Freitag L “One-stop shop” spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology |
| description |
Kaid Darwiche,1 Paul Zarogoulidis,1,2 Leslie Krauss,3 Filiz Oezkan,1 Robert Fred Henry Walter,1,4 Robert Werner,4 Dirk Theegarten,4 Leonidas Sakkas,5 Antonios Sakkas,5 Wolfgang Hohenforst-Scmidt,6 Konstantinos Zarogoulidis,1 Lutz Freitag11Department of Interventional Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany; 2Pulmonary Department, Oncology Unit, G Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 3CytoViva, Inc, Auburn, AL, USA; 4Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany; 5Pathology Department, G Papanikolaou General Hospital, Thessaloniki, Greece; 6II Medical Department, Coburg Regional Clinic, University of Wuerzburg, Coburg, GermanyBackground: There are currently many techniques and devices available for the diagnosis of lung cancer. However, rapid on-site diagnosis is essential for early-stage lung cancer, and in the current work we investigated a new diagnostic illumination nanotechnology.Methods: Tissue samples were obtained from lymph nodes, cancerous tissue, and abnormal intrapulmonary lesions at our interventional pulmonary suites. The following diagnostic techniques were used to obtain the samples: endobronchial ultrasound bronchoscopy; flexible bronchoscopy; and rigid bronchoscopy. Flexible and rigid forceps were used because several of the patients were intubated using a rigid bronchoscope. In total, 30 tissue specimens from 30 patients were prepared. CytoViva® illumination nanotechnology was subsequently applied to each of the biopsy tissue slides.Results: A spectral library was created for adenocarcinoma, epidermal growth factor receptor mutation-positive adenocarcinoma, squamous cell carcinoma, usual interstitial pneumonitis, nonspecific interstitial pneumonitis, typical carcinoid tumor, sarcoidosis, idiopathic pulmonary fibrosis, small cell neuroendocrine carcinoma, thymoma, epithelioid and sarcomatoid mesothelioma, cryptogenic organizing pneumonia, malt cell lymphoma, and Wegener's granulomatosis.Conclusion: The CytoViva software, once it had created a specific spectral library for each entity, was able to identify the same disease again in subsequent paired sets of slides of the same disease. Further evaluation of this technique could make this illumination nanotechnology an efficient rapid on-site diagnostic tool.Keywords: lung cancer, endobronchial ultrasound, spectral imaging, diagnosis |
| format |
article |
| author |
Darwiche K Zarogoulidis P Krauss L Oezkan F Walter RFH Werner R Theegarten D Sakkas L Sakkas A Hohenforst-Schmidt W Zarogoulidis K Freitag L |
| author_facet |
Darwiche K Zarogoulidis P Krauss L Oezkan F Walter RFH Werner R Theegarten D Sakkas L Sakkas A Hohenforst-Schmidt W Zarogoulidis K Freitag L |
| author_sort |
Darwiche K |
| title |
“One-stop shop” spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology |
| title_short |
“One-stop shop” spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology |
| title_full |
“One-stop shop” spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology |
| title_fullStr |
“One-stop shop” spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology |
| title_full_unstemmed |
“One-stop shop” spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology |
| title_sort |
“one-stop shop” spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology |
| publisher |
Dove Medical Press |
| publishDate |
2013 |
| url |
https://doaj.org/article/d1b801badc4f4265a4404f06bf95b2aa |
| work_keys_str_mv |
AT darwichek ldquoonestopshoprdquospectralimagingforrapidonsitediagnosisoflungcancerafutureconceptinnanooncology AT zarogoulidisp ldquoonestopshoprdquospectralimagingforrapidonsitediagnosisoflungcancerafutureconceptinnanooncology AT kraussl ldquoonestopshoprdquospectralimagingforrapidonsitediagnosisoflungcancerafutureconceptinnanooncology AT oezkanf ldquoonestopshoprdquospectralimagingforrapidonsitediagnosisoflungcancerafutureconceptinnanooncology AT walterrfh ldquoonestopshoprdquospectralimagingforrapidonsitediagnosisoflungcancerafutureconceptinnanooncology AT wernerr ldquoonestopshoprdquospectralimagingforrapidonsitediagnosisoflungcancerafutureconceptinnanooncology AT theegartend ldquoonestopshoprdquospectralimagingforrapidonsitediagnosisoflungcancerafutureconceptinnanooncology AT sakkasl ldquoonestopshoprdquospectralimagingforrapidonsitediagnosisoflungcancerafutureconceptinnanooncology AT sakkasa ldquoonestopshoprdquospectralimagingforrapidonsitediagnosisoflungcancerafutureconceptinnanooncology AT hohenforstschmidtw ldquoonestopshoprdquospectralimagingforrapidonsitediagnosisoflungcancerafutureconceptinnanooncology AT zarogoulidisk ldquoonestopshoprdquospectralimagingforrapidonsitediagnosisoflungcancerafutureconceptinnanooncology AT freitagl ldquoonestopshoprdquospectralimagingforrapidonsitediagnosisoflungcancerafutureconceptinnanooncology |
| _version_ |
1718398692158865408 |