Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges

Immune associated cells in the microenvironment have a significant impact on the development and progression of hepatocellular carcinoma (HCC) and have received more and more attention. Different types of immune-associated cells play different roles, including promoting/inhibiting HCC and several di...

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Autores principales:	Xiaopei Hao, Guangshun Sun, Yao Zhang, Xiangyi Kong, Dawei Rong, Jinhua Song, Weiwei Tang, Xuehao Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	HCC TAM NK cell cancer immunotherapy challenge development Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d1bafe28d3f044619713762a5ed6c6a3
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id	oai:doaj.org-article:d1bafe28d3f044619713762a5ed6c6a3
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spelling	oai:doaj.org-article:d1bafe28d3f044619713762a5ed6c6a32021-11-12T07:09:26ZTargeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges2296-634X10.3389/fcell.2021.775462https://doaj.org/article/d1bafe28d3f044619713762a5ed6c6a32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.775462/fullhttps://doaj.org/toc/2296-634XImmune associated cells in the microenvironment have a significant impact on the development and progression of hepatocellular carcinoma (HCC) and have received more and more attention. Different types of immune-associated cells play different roles, including promoting/inhibiting HCC and several different types that are controversial. It is well known that immune escape of HCC has become a difficult problem in tumor therapy. Therefore, in recent years, a large number of studies have focused on the immune microenvironment of HCC, explored many mechanisms worth identifying tumor immunosuppression, and developed a variety of immunotherapy methods as targets, laying the foundation for the final victory in the fight against HCC. This paper reviews recent studies on the immune microenvironment of HCC that are more reliable and important, and provides a more comprehensive view of the investigation of the immune microenvironment of HCC and the development of more immunotherapeutic approaches based on the relevant summaries of different immune cells.Xiaopei HaoGuangshun SunYao ZhangXiangyi KongDawei RongJinhua SongWeiwei TangXuehao WangFrontiers Media S.A.articleHCCTAMNK cellcancer immunotherapychallengedevelopmentBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HCC TAM NK cell cancer immunotherapy challenge development Biology (General) QH301-705.5
spellingShingle	HCC TAM NK cell cancer immunotherapy challenge development Biology (General) QH301-705.5 Xiaopei Hao Guangshun Sun Yao Zhang Xiangyi Kong Dawei Rong Jinhua Song Weiwei Tang Xuehao Wang Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges
description	Immune associated cells in the microenvironment have a significant impact on the development and progression of hepatocellular carcinoma (HCC) and have received more and more attention. Different types of immune-associated cells play different roles, including promoting/inhibiting HCC and several different types that are controversial. It is well known that immune escape of HCC has become a difficult problem in tumor therapy. Therefore, in recent years, a large number of studies have focused on the immune microenvironment of HCC, explored many mechanisms worth identifying tumor immunosuppression, and developed a variety of immunotherapy methods as targets, laying the foundation for the final victory in the fight against HCC. This paper reviews recent studies on the immune microenvironment of HCC that are more reliable and important, and provides a more comprehensive view of the investigation of the immune microenvironment of HCC and the development of more immunotherapeutic approaches based on the relevant summaries of different immune cells.
format	article
author	Xiaopei Hao Guangshun Sun Yao Zhang Xiangyi Kong Dawei Rong Jinhua Song Weiwei Tang Xuehao Wang
author_facet	Xiaopei Hao Guangshun Sun Yao Zhang Xiangyi Kong Dawei Rong Jinhua Song Weiwei Tang Xuehao Wang
author_sort	Xiaopei Hao
title	Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges
title_short	Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges
title_full	Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges
title_fullStr	Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges
title_full_unstemmed	Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges
title_sort	targeting immune cells in the tumor microenvironment of hcc: new opportunities and challenges
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d1bafe28d3f044619713762a5ed6c6a3
work_keys_str_mv	AT xiaopeihao targetingimmunecellsinthetumormicroenvironmentofhccnewopportunitiesandchallenges AT guangshunsun targetingimmunecellsinthetumormicroenvironmentofhccnewopportunitiesandchallenges AT yaozhang targetingimmunecellsinthetumormicroenvironmentofhccnewopportunitiesandchallenges AT xiangyikong targetingimmunecellsinthetumormicroenvironmentofhccnewopportunitiesandchallenges AT daweirong targetingimmunecellsinthetumormicroenvironmentofhccnewopportunitiesandchallenges AT jinhuasong targetingimmunecellsinthetumormicroenvironmentofhccnewopportunitiesandchallenges AT weiweitang targetingimmunecellsinthetumormicroenvironmentofhccnewopportunitiesandchallenges AT xuehaowang targetingimmunecellsinthetumormicroenvironmentofhccnewopportunitiesandchallenges
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Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges

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