Clinical Efficacy of Methotrexate Combined with Iguratimod on Patients with Rheumatoid Arthritis and Its Influence on the Expression Levels of HOTAIR in Serum

Objective. This study was designed to explore the clinical efficacy of methotrexate combined with iguratimod on patients with rheumatoid arthritis (RA) and its influence on the expression levels of HOTAIR in serum. Methods. A total of 268 RA patients were selected as research objects, 145 patients r...

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Autores principales: Jingya Tan, Jiaqiang Dan, Yi Liu
Formato: article
Lenguaje:EN
Publicado: Hindawi Limited 2021
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Acceso en línea:https://doaj.org/article/d1bf69be84ad47d4884e47dedf073aa9
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spelling oai:doaj.org-article:d1bf69be84ad47d4884e47dedf073aa92021-11-22T01:11:15ZClinical Efficacy of Methotrexate Combined with Iguratimod on Patients with Rheumatoid Arthritis and Its Influence on the Expression Levels of HOTAIR in Serum2314-614110.1155/2021/2486617https://doaj.org/article/d1bf69be84ad47d4884e47dedf073aa92021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/2486617https://doaj.org/toc/2314-6141Objective. This study was designed to explore the clinical efficacy of methotrexate combined with iguratimod on patients with rheumatoid arthritis (RA) and its influence on the expression levels of HOTAIR in serum. Methods. A total of 268 RA patients were selected as research objects, 145 patients received methotrexate alone were used as a control group (CG), 123 patients received methotrexate combined with iguratimod were taken as a research group (RG), and serum of 60 healthy people undergoing physical examination was selected as a healthy control group (HCG). The therapeutic value of two therapeutic methods for RA was compared, and the HOTAIR expression in serum was detected by qRT-PCR. Results. Compared with methotrexate used alone, the joint use of methotrexate and iguratimod could provide better clinical efficacy for RA patients and would not increase the incidence of adverse events. HOTAIR was highly expressed in the serum of RA patients, and its expression decreased after treatment. Conclusion. Combination therapy of methotrexate and iguratimod is a safe and effective way to treat RA patients, which can be popularized clinically.Jingya TanJiaqiang DanYi LiuHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
spellingShingle Medicine
R
Jingya Tan
Jiaqiang Dan
Yi Liu
Clinical Efficacy of Methotrexate Combined with Iguratimod on Patients with Rheumatoid Arthritis and Its Influence on the Expression Levels of HOTAIR in Serum
description Objective. This study was designed to explore the clinical efficacy of methotrexate combined with iguratimod on patients with rheumatoid arthritis (RA) and its influence on the expression levels of HOTAIR in serum. Methods. A total of 268 RA patients were selected as research objects, 145 patients received methotrexate alone were used as a control group (CG), 123 patients received methotrexate combined with iguratimod were taken as a research group (RG), and serum of 60 healthy people undergoing physical examination was selected as a healthy control group (HCG). The therapeutic value of two therapeutic methods for RA was compared, and the HOTAIR expression in serum was detected by qRT-PCR. Results. Compared with methotrexate used alone, the joint use of methotrexate and iguratimod could provide better clinical efficacy for RA patients and would not increase the incidence of adverse events. HOTAIR was highly expressed in the serum of RA patients, and its expression decreased after treatment. Conclusion. Combination therapy of methotrexate and iguratimod is a safe and effective way to treat RA patients, which can be popularized clinically.
format article
author Jingya Tan
Jiaqiang Dan
Yi Liu
author_facet Jingya Tan
Jiaqiang Dan
Yi Liu
author_sort Jingya Tan
title Clinical Efficacy of Methotrexate Combined with Iguratimod on Patients with Rheumatoid Arthritis and Its Influence on the Expression Levels of HOTAIR in Serum
title_short Clinical Efficacy of Methotrexate Combined with Iguratimod on Patients with Rheumatoid Arthritis and Its Influence on the Expression Levels of HOTAIR in Serum
title_full Clinical Efficacy of Methotrexate Combined with Iguratimod on Patients with Rheumatoid Arthritis and Its Influence on the Expression Levels of HOTAIR in Serum
title_fullStr Clinical Efficacy of Methotrexate Combined with Iguratimod on Patients with Rheumatoid Arthritis and Its Influence on the Expression Levels of HOTAIR in Serum
title_full_unstemmed Clinical Efficacy of Methotrexate Combined with Iguratimod on Patients with Rheumatoid Arthritis and Its Influence on the Expression Levels of HOTAIR in Serum
title_sort clinical efficacy of methotrexate combined with iguratimod on patients with rheumatoid arthritis and its influence on the expression levels of hotair in serum
publisher Hindawi Limited
publishDate 2021
url https://doaj.org/article/d1bf69be84ad47d4884e47dedf073aa9
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