Synthesis and Discovery of Schiff Base Bearing Furopyrimidinone for Selective Recognition of Zn2+ and its Applications in Cell Imaging and Detection of Cu2+
A simplefuro [2,3-d]pyrimidinone-based Schiff base FPS was synthesized via aza-Wittig reaction and structure elucidation was carried out by spectroscopic studies FT-IR, 1H NMR, and 13C NMR and mass spectrometry. FPS showed weak fluorescence emission in methanol and the selectivity of FPS to differen...
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2021
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oai:doaj.org-article:d1c26185ae4643448ff92e1649ccf8782021-12-01T12:44:47ZSynthesis and Discovery of Schiff Base Bearing Furopyrimidinone for Selective Recognition of Zn2+ and its Applications in Cell Imaging and Detection of Cu2+2296-264610.3389/fchem.2021.774090https://doaj.org/article/d1c26185ae4643448ff92e1649ccf8782021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.774090/fullhttps://doaj.org/toc/2296-2646A simplefuro [2,3-d]pyrimidinone-based Schiff base FPS was synthesized via aza-Wittig reaction and structure elucidation was carried out by spectroscopic studies FT-IR, 1H NMR, and 13C NMR and mass spectrometry. FPS showed weak fluorescence emission in methanol and the selectivity of FPS to different metal ions (Mn2+, Ca2+, Fe2+, Fe3+, Mg2+, Al3+, Ba2+, Ag+, Co2+, Na+, K+, Cu2+, Zn2+, Pb2+, Bi3+) were studied by absorption and fluorescence titration. The results show that FPS has selective fluorescence sensing behavior for Zn2+ ions and the limit of detection (LOD) was calculated to be 1.19 × 10–8 mol/L. Moreover, FPS-Zn2+ acts as a metal based highly selective and sensitive new chemosensor for Cu2+ ions and the LOD was calculated to be 2.25 × 10–7 mol/L. In accordance with the results and theoretical calculations, we suspected that the binding mechanisms of FPS to Zn2+ and Cu2+ were assigned to be the cooperative interaction of Zn2+(Cu2+)-N.Yanggen HuChao LuoLili GuiJing LuJuncai FuXinya HanJunkai MaLun LuoFrontiers Media S.A.articlefuro[2, 3-d]pyrimidinoneschiff basefluorescenceZn2+ recognitionCu2+/Fe2+ detectionlive cells imagingChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021) |
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furo[2, 3-d]pyrimidinone schiff base fluorescence Zn2+ recognition Cu2+/Fe2+ detection live cells imaging Chemistry QD1-999 |
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furo[2, 3-d]pyrimidinone schiff base fluorescence Zn2+ recognition Cu2+/Fe2+ detection live cells imaging Chemistry QD1-999 Yanggen Hu Chao Luo Lili Gui Jing Lu Juncai Fu Xinya Han Junkai Ma Lun Luo Synthesis and Discovery of Schiff Base Bearing Furopyrimidinone for Selective Recognition of Zn2+ and its Applications in Cell Imaging and Detection of Cu2+ |
| description |
A simplefuro [2,3-d]pyrimidinone-based Schiff base FPS was synthesized via aza-Wittig reaction and structure elucidation was carried out by spectroscopic studies FT-IR, 1H NMR, and 13C NMR and mass spectrometry. FPS showed weak fluorescence emission in methanol and the selectivity of FPS to different metal ions (Mn2+, Ca2+, Fe2+, Fe3+, Mg2+, Al3+, Ba2+, Ag+, Co2+, Na+, K+, Cu2+, Zn2+, Pb2+, Bi3+) were studied by absorption and fluorescence titration. The results show that FPS has selective fluorescence sensing behavior for Zn2+ ions and the limit of detection (LOD) was calculated to be 1.19 × 10–8 mol/L. Moreover, FPS-Zn2+ acts as a metal based highly selective and sensitive new chemosensor for Cu2+ ions and the LOD was calculated to be 2.25 × 10–7 mol/L. In accordance with the results and theoretical calculations, we suspected that the binding mechanisms of FPS to Zn2+ and Cu2+ were assigned to be the cooperative interaction of Zn2+(Cu2+)-N. |
| format |
article |
| author |
Yanggen Hu Chao Luo Lili Gui Jing Lu Juncai Fu Xinya Han Junkai Ma Lun Luo |
| author_facet |
Yanggen Hu Chao Luo Lili Gui Jing Lu Juncai Fu Xinya Han Junkai Ma Lun Luo |
| author_sort |
Yanggen Hu |
| title |
Synthesis and Discovery of Schiff Base Bearing Furopyrimidinone for Selective Recognition of Zn2+ and its Applications in Cell Imaging and Detection of Cu2+ |
| title_short |
Synthesis and Discovery of Schiff Base Bearing Furopyrimidinone for Selective Recognition of Zn2+ and its Applications in Cell Imaging and Detection of Cu2+ |
| title_full |
Synthesis and Discovery of Schiff Base Bearing Furopyrimidinone for Selective Recognition of Zn2+ and its Applications in Cell Imaging and Detection of Cu2+ |
| title_fullStr |
Synthesis and Discovery of Schiff Base Bearing Furopyrimidinone for Selective Recognition of Zn2+ and its Applications in Cell Imaging and Detection of Cu2+ |
| title_full_unstemmed |
Synthesis and Discovery of Schiff Base Bearing Furopyrimidinone for Selective Recognition of Zn2+ and its Applications in Cell Imaging and Detection of Cu2+ |
| title_sort |
synthesis and discovery of schiff base bearing furopyrimidinone for selective recognition of zn2+ and its applications in cell imaging and detection of cu2+ |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/d1c26185ae4643448ff92e1649ccf878 |
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