LOCAL IMMUNITY AND GUT MICROFLORA IN THE SALMONELLA CARRIERS АND APPROACHES TO ITS TREATMENT

Abstract. Features of local immunity were studied in the patients with Salmonella infection at reconvalescence, both without carriership, and in reconvalescent carriers of microbial flora (RCM). In RCMs, as compared to non-carriers, some alterations in gut microbiocenosis were revealed, along with l...

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Autores principales:	I. N. Chainikova, A. I. Smoliagin, M. V. Skachkov, T. N. Kalinina, O. V. Bukharin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	local immunity salmonella infection reconvalescent carriers of microbial flora polyoxidonium Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d1c3b29bfb7c45a796b6e1e044a3f4af
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spelling	oai:doaj.org-article:d1c3b29bfb7c45a796b6e1e044a3f4af2021-11-18T08:03:37ZLOCAL IMMUNITY AND GUT MICROFLORA IN THE SALMONELLA CARRIERS АND APPROACHES TO ITS TREATMENT1563-06252313-741X10.15789/1563-0625-2008-1-35-42https://doaj.org/article/d1c3b29bfb7c45a796b6e1e044a3f4af2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/76https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Features of local immunity were studied in the patients with Salmonella infection at reconvalescence, both without carriership, and in reconvalescent carriers of microbial flora (RCM). In RCMs, as compared to non-carriers, some alterations in gut microbiocenosis were revealed, along with local deficiency of antimicrobial defense factors, i.e., lactoferrin, lysozyme, secretory IgA, free secretory component, antibodies to Salmonella O-antigen, IgA, as opposed to high levels of IgM, IgG (due to IgG1 and IgG4), cytokines (IL-6, IL-8, IFNγ, IL-4). It was shown that sIgA and IgA deficiency are connected with their mangling local production, whereas the revealed increase in IgМ and IgG concentrations proved to be a consequence of increased local synthesis. Application of polyoxidonium (PO) in RCMs lead to improvement in the gut microenvironment, thus reflected by decreased contamination with facultative flora, disappearance of Proteus, Candida spp. and recovery of indigenous anaerobic flora in 92 per cent of cases. Positive dynamics of local immunity associated with PO treatment was justified by restoration of total IgA and sIgA concentrations, due to enhanced local synthesis, increase in free secretory component, higher titers of antibodies to Salmonella O-antigen, and changes in cytokine contents, with restoration of Th1/Th2 cytokine balance. Under in vitro conditions, a PO-associated suppression of anti-complement Salmonella activity was registered, thus rendering positive effects of the drug towards symbionts in the «host-parasite» system, and shortening the terms of microbial excretion in Salmonella carriers.I. N. ChainikovaA. I. SmoliaginM. V. SkachkovT. N. KalininaO. V. BukharinSPb RAACIarticlelocal immunitysalmonella infectionreconvalescent carriers of microbial florapolyoxidoniumImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 1, Pp 35-42 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	local immunity salmonella infection reconvalescent carriers of microbial flora polyoxidonium Immunologic diseases. Allergy RC581-607
spellingShingle	local immunity salmonella infection reconvalescent carriers of microbial flora polyoxidonium Immunologic diseases. Allergy RC581-607 I. N. Chainikova A. I. Smoliagin M. V. Skachkov T. N. Kalinina O. V. Bukharin LOCAL IMMUNITY AND GUT MICROFLORA IN THE SALMONELLA CARRIERS АND APPROACHES TO ITS TREATMENT
description	Abstract. Features of local immunity were studied in the patients with Salmonella infection at reconvalescence, both without carriership, and in reconvalescent carriers of microbial flora (RCM). In RCMs, as compared to non-carriers, some alterations in gut microbiocenosis were revealed, along with local deficiency of antimicrobial defense factors, i.e., lactoferrin, lysozyme, secretory IgA, free secretory component, antibodies to Salmonella O-antigen, IgA, as opposed to high levels of IgM, IgG (due to IgG1 and IgG4), cytokines (IL-6, IL-8, IFNγ, IL-4). It was shown that sIgA and IgA deficiency are connected with their mangling local production, whereas the revealed increase in IgМ and IgG concentrations proved to be a consequence of increased local synthesis. Application of polyoxidonium (PO) in RCMs lead to improvement in the gut microenvironment, thus reflected by decreased contamination with facultative flora, disappearance of Proteus, Candida spp. and recovery of indigenous anaerobic flora in 92 per cent of cases. Positive dynamics of local immunity associated with PO treatment was justified by restoration of total IgA and sIgA concentrations, due to enhanced local synthesis, increase in free secretory component, higher titers of antibodies to Salmonella O-antigen, and changes in cytokine contents, with restoration of Th1/Th2 cytokine balance. Under in vitro conditions, a PO-associated suppression of anti-complement Salmonella activity was registered, thus rendering positive effects of the drug towards symbionts in the «host-parasite» system, and shortening the terms of microbial excretion in Salmonella carriers.
format	article
author	I. N. Chainikova A. I. Smoliagin M. V. Skachkov T. N. Kalinina O. V. Bukharin
author_facet	I. N. Chainikova A. I. Smoliagin M. V. Skachkov T. N. Kalinina O. V. Bukharin
author_sort	I. N. Chainikova
title	LOCAL IMMUNITY AND GUT MICROFLORA IN THE SALMONELLA CARRIERS АND APPROACHES TO ITS TREATMENT
title_short	LOCAL IMMUNITY AND GUT MICROFLORA IN THE SALMONELLA CARRIERS АND APPROACHES TO ITS TREATMENT
title_full	LOCAL IMMUNITY AND GUT MICROFLORA IN THE SALMONELLA CARRIERS АND APPROACHES TO ITS TREATMENT
title_fullStr	LOCAL IMMUNITY AND GUT MICROFLORA IN THE SALMONELLA CARRIERS АND APPROACHES TO ITS TREATMENT
title_full_unstemmed	LOCAL IMMUNITY AND GUT MICROFLORA IN THE SALMONELLA CARRIERS АND APPROACHES TO ITS TREATMENT
title_sort	local immunity and gut microflora in the salmonella carriers аnd approaches to its treatment
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/d1c3b29bfb7c45a796b6e1e044a3f4af
work_keys_str_mv	AT inchainikova localimmunityandgutmicroflorainthesalmonellacarriersandapproachestoitstreatment AT aismoliagin localimmunityandgutmicroflorainthesalmonellacarriersandapproachestoitstreatment AT mvskachkov localimmunityandgutmicroflorainthesalmonellacarriersandapproachestoitstreatment AT tnkalinina localimmunityandgutmicroflorainthesalmonellacarriersandapproachestoitstreatment AT ovbukharin localimmunityandgutmicroflorainthesalmonellacarriersandapproachestoitstreatment
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LOCAL IMMUNITY AND GUT MICROFLORA IN THE SALMONELLA CARRIERS АND APPROACHES TO ITS TREATMENT

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