Decreased annual risk of tuberculosis infection in South Korean healthcare workers using interferon-gamma release assay between 1986 and 2005

Abstract Background Tuberculosis (TB) has been a major public health problem in South Korea. Although TB notification rate in Korea is gradually decreasing, still highest among the member countries of the Organization for Economic Cooperation and Development. To effectively control TB, understanding...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eun Hye Lee, Nak-Hoon Son, Se Hyun Kwak, Ji Soo Choi, Min Chul Kim, Chang Hwan Seol, Sung-Ryeol Kim, Byung Hoon Park, Young Ae Kang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Latent tuberculosis infection Prevalence Annual risk of infection Interferon-gamma release assays Health care workers Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/d1c3e9c91a9e4a989a6721bddde50d7e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d1c3e9c91a9e4a989a6721bddde50d7e
record_format	dspace
spelling	oai:doaj.org-article:d1c3e9c91a9e4a989a6721bddde50d7e2021-11-21T12:42:39ZDecreased annual risk of tuberculosis infection in South Korean healthcare workers using interferon-gamma release assay between 1986 and 200510.1186/s12879-021-06855-51471-2334https://doaj.org/article/d1c3e9c91a9e4a989a6721bddde50d7e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06855-5https://doaj.org/toc/1471-2334Abstract Background Tuberculosis (TB) has been a major public health problem in South Korea. Although TB notification rate in Korea is gradually decreasing, still highest among the member countries of the Organization for Economic Cooperation and Development. To effectively control TB, understanding the TB epidemiology such as prevalence of latent tuberculosis infection (LTBI) and annual risk of TB infection (ARI) are important. This study aimed to identify the prevalence of LTBI and ARI among South Korean health care workers (HCWs) based on their interferon-gamma release assays (IGRA). Methods This was single center, cross-sectional retrospective study in a tertiary hospital in South Korea. We performed IGRA in HCWs between May 2017 and March 2018. We estimated ARI based on IGRA results. Logistic regression model was used to identify factors affecting IGRA positivity. Results A total of 3233 HCWs were analyzed. Median age of participants was 38.0 and female was predominant (72.6%). Overall positive rate of IGRA was 24.1% and IGRA positive rates age-group wise were 6.6%, 14.4%, 34.3%, and around 50% in the age groups 20s, 30s, 40s, and 50s and 60s, respectively. The ARIs was 0.26–1.35% between 1986 and 2005; rate of TB infection has gradually decreased in the last two decades. Multivariable analysis indicated that older age, healed TB lesion in x-ray, and male gender were risk factors for IGRA positivity, whereas working in high-risk TB departments was not. Conclusions Results showed that ARI in South Korean HCWs gradually decreased over two decades, although LTBI remained prevalent. Our results suggest that the LTBI test result of HCWs might be greatly affected by age, rather than occupational exposure, in intermediate TB burden countries. Thus, careful interpretation considering the age structure is required.Eun Hye LeeNak-Hoon SonSe Hyun KwakJi Soo ChoiMin Chul KimChang Hwan SeolSung-Ryeol KimByung Hoon ParkYoung Ae KangBMCarticleLatent tuberculosis infectionPrevalenceAnnual risk of infectionInterferon-gamma release assaysHealth care workersInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Latent tuberculosis infection Prevalence Annual risk of infection Interferon-gamma release assays Health care workers Infectious and parasitic diseases RC109-216
spellingShingle	Latent tuberculosis infection Prevalence Annual risk of infection Interferon-gamma release assays Health care workers Infectious and parasitic diseases RC109-216 Eun Hye Lee Nak-Hoon Son Se Hyun Kwak Ji Soo Choi Min Chul Kim Chang Hwan Seol Sung-Ryeol Kim Byung Hoon Park Young Ae Kang Decreased annual risk of tuberculosis infection in South Korean healthcare workers using interferon-gamma release assay between 1986 and 2005
description	Abstract Background Tuberculosis (TB) has been a major public health problem in South Korea. Although TB notification rate in Korea is gradually decreasing, still highest among the member countries of the Organization for Economic Cooperation and Development. To effectively control TB, understanding the TB epidemiology such as prevalence of latent tuberculosis infection (LTBI) and annual risk of TB infection (ARI) are important. This study aimed to identify the prevalence of LTBI and ARI among South Korean health care workers (HCWs) based on their interferon-gamma release assays (IGRA). Methods This was single center, cross-sectional retrospective study in a tertiary hospital in South Korea. We performed IGRA in HCWs between May 2017 and March 2018. We estimated ARI based on IGRA results. Logistic regression model was used to identify factors affecting IGRA positivity. Results A total of 3233 HCWs were analyzed. Median age of participants was 38.0 and female was predominant (72.6%). Overall positive rate of IGRA was 24.1% and IGRA positive rates age-group wise were 6.6%, 14.4%, 34.3%, and around 50% in the age groups 20s, 30s, 40s, and 50s and 60s, respectively. The ARIs was 0.26–1.35% between 1986 and 2005; rate of TB infection has gradually decreased in the last two decades. Multivariable analysis indicated that older age, healed TB lesion in x-ray, and male gender were risk factors for IGRA positivity, whereas working in high-risk TB departments was not. Conclusions Results showed that ARI in South Korean HCWs gradually decreased over two decades, although LTBI remained prevalent. Our results suggest that the LTBI test result of HCWs might be greatly affected by age, rather than occupational exposure, in intermediate TB burden countries. Thus, careful interpretation considering the age structure is required.
format	article
author	Eun Hye Lee Nak-Hoon Son Se Hyun Kwak Ji Soo Choi Min Chul Kim Chang Hwan Seol Sung-Ryeol Kim Byung Hoon Park Young Ae Kang
author_facet	Eun Hye Lee Nak-Hoon Son Se Hyun Kwak Ji Soo Choi Min Chul Kim Chang Hwan Seol Sung-Ryeol Kim Byung Hoon Park Young Ae Kang
author_sort	Eun Hye Lee
title	Decreased annual risk of tuberculosis infection in South Korean healthcare workers using interferon-gamma release assay between 1986 and 2005
title_short	Decreased annual risk of tuberculosis infection in South Korean healthcare workers using interferon-gamma release assay between 1986 and 2005
title_full	Decreased annual risk of tuberculosis infection in South Korean healthcare workers using interferon-gamma release assay between 1986 and 2005
title_fullStr	Decreased annual risk of tuberculosis infection in South Korean healthcare workers using interferon-gamma release assay between 1986 and 2005
title_full_unstemmed	Decreased annual risk of tuberculosis infection in South Korean healthcare workers using interferon-gamma release assay between 1986 and 2005
title_sort	decreased annual risk of tuberculosis infection in south korean healthcare workers using interferon-gamma release assay between 1986 and 2005
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d1c3e9c91a9e4a989a6721bddde50d7e
work_keys_str_mv	AT eunhyelee decreasedannualriskoftuberculosisinfectioninsouthkoreanhealthcareworkersusinginterferongammareleaseassaybetween1986and2005 AT nakhoonson decreasedannualriskoftuberculosisinfectioninsouthkoreanhealthcareworkersusinginterferongammareleaseassaybetween1986and2005 AT sehyunkwak decreasedannualriskoftuberculosisinfectioninsouthkoreanhealthcareworkersusinginterferongammareleaseassaybetween1986and2005 AT jisoochoi decreasedannualriskoftuberculosisinfectioninsouthkoreanhealthcareworkersusinginterferongammareleaseassaybetween1986and2005 AT minchulkim decreasedannualriskoftuberculosisinfectioninsouthkoreanhealthcareworkersusinginterferongammareleaseassaybetween1986and2005 AT changhwanseol decreasedannualriskoftuberculosisinfectioninsouthkoreanhealthcareworkersusinginterferongammareleaseassaybetween1986and2005 AT sungryeolkim decreasedannualriskoftuberculosisinfectioninsouthkoreanhealthcareworkersusinginterferongammareleaseassaybetween1986and2005 AT byunghoonpark decreasedannualriskoftuberculosisinfectioninsouthkoreanhealthcareworkersusinginterferongammareleaseassaybetween1986and2005 AT youngaekang decreasedannualriskoftuberculosisinfectioninsouthkoreanhealthcareworkersusinginterferongammareleaseassaybetween1986and2005
_version_	1718418854200213504

Decreased annual risk of tuberculosis infection in South Korean healthcare workers using interferon-gamma release assay between 1986 and 2005

Ejemplares similares