YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
Hypoxia occurs at high altitude and in cancer. Here, the authors show that a gene involved in hypoxia, YTHDF1, underwent rapid evolution in Tibetans and their domestic animals, and find that the gene is amplified in some cancers and contributes to drug resistance in hypoxic conditions.
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Nature Portfolio
2019
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Acceso en línea: | https://doaj.org/article/d1c5532fac1b4a15a88397d24a21c802 |
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oai:doaj.org-article:d1c5532fac1b4a15a88397d24a21c8022021-12-02T17:01:31ZYTHDF1 links hypoxia adaptation and non-small cell lung cancer progression10.1038/s41467-019-12801-62041-1723https://doaj.org/article/d1c5532fac1b4a15a88397d24a21c8022019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12801-6https://doaj.org/toc/2041-1723Hypoxia occurs at high altitude and in cancer. Here, the authors show that a gene involved in hypoxia, YTHDF1, underwent rapid evolution in Tibetans and their domestic animals, and find that the gene is amplified in some cancers and contributes to drug resistance in hypoxic conditions.Yulin ShiSongqing FanMengge WuZhixiang ZuoXingyang LiLiping JiangQiushuo ShenPeifang XuLin ZengYongchun ZhouYunchao HuangZuozhang YangJumin ZhouJing GaoHu ZhouShuhua XuHongbin JiPeng ShiDong-Dong WuCuiping YangYongbin ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
institution |
DOAJ |
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DOAJ |
language |
EN |
topic |
Science Q |
spellingShingle |
Science Q Yulin Shi Songqing Fan Mengge Wu Zhixiang Zuo Xingyang Li Liping Jiang Qiushuo Shen Peifang Xu Lin Zeng Yongchun Zhou Yunchao Huang Zuozhang Yang Jumin Zhou Jing Gao Hu Zhou Shuhua Xu Hongbin Ji Peng Shi Dong-Dong Wu Cuiping Yang Yongbin Chen YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression |
description |
Hypoxia occurs at high altitude and in cancer. Here, the authors show that a gene involved in hypoxia, YTHDF1, underwent rapid evolution in Tibetans and their domestic animals, and find that the gene is amplified in some cancers and contributes to drug resistance in hypoxic conditions. |
format |
article |
author |
Yulin Shi Songqing Fan Mengge Wu Zhixiang Zuo Xingyang Li Liping Jiang Qiushuo Shen Peifang Xu Lin Zeng Yongchun Zhou Yunchao Huang Zuozhang Yang Jumin Zhou Jing Gao Hu Zhou Shuhua Xu Hongbin Ji Peng Shi Dong-Dong Wu Cuiping Yang Yongbin Chen |
author_facet |
Yulin Shi Songqing Fan Mengge Wu Zhixiang Zuo Xingyang Li Liping Jiang Qiushuo Shen Peifang Xu Lin Zeng Yongchun Zhou Yunchao Huang Zuozhang Yang Jumin Zhou Jing Gao Hu Zhou Shuhua Xu Hongbin Ji Peng Shi Dong-Dong Wu Cuiping Yang Yongbin Chen |
author_sort |
Yulin Shi |
title |
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression |
title_short |
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression |
title_full |
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression |
title_fullStr |
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression |
title_full_unstemmed |
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression |
title_sort |
ythdf1 links hypoxia adaptation and non-small cell lung cancer progression |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/d1c5532fac1b4a15a88397d24a21c802 |
work_keys_str_mv |
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1718382114672476160 |