YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression

YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression

Hypoxia occurs at high altitude and in cancer. Here, the authors show that a gene involved in hypoxia, YTHDF1, underwent rapid evolution in Tibetans and their domestic animals, and find that the gene is amplified in some cancers and contributes to drug resistance in hypoxic conditions.

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Bibliographic Details
Main Authors: Yulin Shi, Songqing Fan, Mengge Wu, Zhixiang Zuo, Xingyang Li, Liping Jiang, Qiushuo Shen, Peifang Xu, Lin Zeng, Yongchun Zhou, Yunchao Huang, Zuozhang Yang, Jumin Zhou, Jing Gao, Hu Zhou, Shuhua Xu, Hongbin Ji, Peng Shi, Dong-Dong Wu, Cuiping Yang, Yongbin Chen
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/d1c5532fac1b4a15a88397d24a21c802
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