Dosimetric evaluation of analytic anisotropic algorithm and Acuros XB algorithm using in-house developed heterogeneous thorax phantom and homogeneous slab phantom for stereotactic body radiation therapy technique

To perform patient-specific quality assurance (QA), the accuracy of the dose calculation algorithm is vital, especially in the lung cancer stereotactic body radiation therapy (SBRT). The present study is based on the evaluation of two widely used algorithms, analytical anisotropic algorithm (AAA) an...

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Autores principales:	Swati Dubey, Priyusha Bagdare, Sanjay Ghosh
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	acuros xb analytical anisotropic algorithm heterogeneous thorax phantom homogeneous slab phantom patient-specific quality assurance Nuclear and particle physics. Atomic energy. Radioactivity QC770-798
Acceso en línea:	https://doaj.org/article/d1c59cc0c5d34afd99876fc40117dcea
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spelling	oai:doaj.org-article:d1c59cc0c5d34afd99876fc40117dcea2021-11-12T11:12:05ZDosimetric evaluation of analytic anisotropic algorithm and Acuros XB algorithm using in-house developed heterogeneous thorax phantom and homogeneous slab phantom for stereotactic body radiation therapy technique0972-046410.4103/rpe.rpe_52_20https://doaj.org/article/d1c59cc0c5d34afd99876fc40117dcea2021-01-01T00:00:00Zhttp://www.rpe.org.in/article.asp?issn=0972-0464;year=2021;volume=44;issue=2;spage=110;epage=115;aulast=Dubeyhttps://doaj.org/toc/0972-0464To perform patient-specific quality assurance (QA), the accuracy of the dose calculation algorithm is vital, especially in the lung cancer stereotactic body radiation therapy (SBRT). The present study is based on the evaluation of two widely used algorithms, analytical anisotropic algorithm (AAA) and Acuros XB (AXB) inside the in-house developed heterogeneous thorax phantom (HTP) and a homogeneous slab phantom (HSP) simultaneously. To evaluate dosimetric differences between the two algorithms, point dose measurement was performed for pretreatment QA plans of 35 lung cancer patients by keeping the same monitor units and beam angles as those for the actual patient treatment. The dose was calculated on the Eclipse treatment planning system inside both the medium by using both AAA and AXB algorithms. Plans were delivered on the Edge linear accelerator (LA) (Varian Medical Systems, Palo Alto, CA, USA), and measurements were taken by using a 0.01 cc ion chamber and DOSE1 electrometer. Statistical analysis was performed on the observed data set, and percentage (%) variations between the measured and planned doses were calculated and analyzed. The mean % variations between the measured and planned doses inside HTP for all QA plans were found to be 2.61 (standard deviation [SD]: 0.66) and 2.19 (SD: 0.64) for AAA and AXB algorithms, respectively. Whereas, inside HSP, it was found to be 1.79 (SD: 0.74) and 1.64 (SD: 0.70) for AAA and AXB algorithms, respectively. The mean % difference between the measured dose and the planned dose was derived to be statistically significant for HTP, however, it was found to be statistically insignificant inside the HSP at P < 0.01. The Pearson's correlation coefficient test showed a strong positive correlation between the measured dose and the planned dose for both AAA and AXB inside HTP as well for HSP. The results obtained from this study showed that as the actual patient body is heterogeneous, thus to get more realistic results, patient-specific QA must be performed inside the heterogeneous phantom instead of homogeneous. Moreover, in the homogeneous medium, both the algorithms predict the dose efficiently, however, in heterogeneous medium, AAA over/under predicts the dose, whereas AXB shows good concurrence with measurements.Swati DubeyPriyusha BagdareSanjay GhoshWolters Kluwer Medknow Publicationsarticleacuros xbanalytical anisotropic algorithmheterogeneous thorax phantomhomogeneous slab phantompatient-specific quality assuranceNuclear and particle physics. Atomic energy. RadioactivityQC770-798ENRadiation Protection and Environment, Vol 44, Iss 2, Pp 110-115 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acuros xb analytical anisotropic algorithm heterogeneous thorax phantom homogeneous slab phantom patient-specific quality assurance Nuclear and particle physics. Atomic energy. Radioactivity QC770-798
spellingShingle	acuros xb analytical anisotropic algorithm heterogeneous thorax phantom homogeneous slab phantom patient-specific quality assurance Nuclear and particle physics. Atomic energy. Radioactivity QC770-798 Swati Dubey Priyusha Bagdare Sanjay Ghosh Dosimetric evaluation of analytic anisotropic algorithm and Acuros XB algorithm using in-house developed heterogeneous thorax phantom and homogeneous slab phantom for stereotactic body radiation therapy technique
description	To perform patient-specific quality assurance (QA), the accuracy of the dose calculation algorithm is vital, especially in the lung cancer stereotactic body radiation therapy (SBRT). The present study is based on the evaluation of two widely used algorithms, analytical anisotropic algorithm (AAA) and Acuros XB (AXB) inside the in-house developed heterogeneous thorax phantom (HTP) and a homogeneous slab phantom (HSP) simultaneously. To evaluate dosimetric differences between the two algorithms, point dose measurement was performed for pretreatment QA plans of 35 lung cancer patients by keeping the same monitor units and beam angles as those for the actual patient treatment. The dose was calculated on the Eclipse treatment planning system inside both the medium by using both AAA and AXB algorithms. Plans were delivered on the Edge linear accelerator (LA) (Varian Medical Systems, Palo Alto, CA, USA), and measurements were taken by using a 0.01 cc ion chamber and DOSE1 electrometer. Statistical analysis was performed on the observed data set, and percentage (%) variations between the measured and planned doses were calculated and analyzed. The mean % variations between the measured and planned doses inside HTP for all QA plans were found to be 2.61 (standard deviation [SD]: 0.66) and 2.19 (SD: 0.64) for AAA and AXB algorithms, respectively. Whereas, inside HSP, it was found to be 1.79 (SD: 0.74) and 1.64 (SD: 0.70) for AAA and AXB algorithms, respectively. The mean % difference between the measured dose and the planned dose was derived to be statistically significant for HTP, however, it was found to be statistically insignificant inside the HSP at P < 0.01. The Pearson's correlation coefficient test showed a strong positive correlation between the measured dose and the planned dose for both AAA and AXB inside HTP as well for HSP. The results obtained from this study showed that as the actual patient body is heterogeneous, thus to get more realistic results, patient-specific QA must be performed inside the heterogeneous phantom instead of homogeneous. Moreover, in the homogeneous medium, both the algorithms predict the dose efficiently, however, in heterogeneous medium, AAA over/under predicts the dose, whereas AXB shows good concurrence with measurements.
format	article
author	Swati Dubey Priyusha Bagdare Sanjay Ghosh
author_facet	Swati Dubey Priyusha Bagdare Sanjay Ghosh
author_sort	Swati Dubey
title	Dosimetric evaluation of analytic anisotropic algorithm and Acuros XB algorithm using in-house developed heterogeneous thorax phantom and homogeneous slab phantom for stereotactic body radiation therapy technique
title_short	Dosimetric evaluation of analytic anisotropic algorithm and Acuros XB algorithm using in-house developed heterogeneous thorax phantom and homogeneous slab phantom for stereotactic body radiation therapy technique
title_full	Dosimetric evaluation of analytic anisotropic algorithm and Acuros XB algorithm using in-house developed heterogeneous thorax phantom and homogeneous slab phantom for stereotactic body radiation therapy technique
title_fullStr	Dosimetric evaluation of analytic anisotropic algorithm and Acuros XB algorithm using in-house developed heterogeneous thorax phantom and homogeneous slab phantom for stereotactic body radiation therapy technique
title_full_unstemmed	Dosimetric evaluation of analytic anisotropic algorithm and Acuros XB algorithm using in-house developed heterogeneous thorax phantom and homogeneous slab phantom for stereotactic body radiation therapy technique
title_sort	dosimetric evaluation of analytic anisotropic algorithm and acuros xb algorithm using in-house developed heterogeneous thorax phantom and homogeneous slab phantom for stereotactic body radiation therapy technique
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/d1c59cc0c5d34afd99876fc40117dcea
work_keys_str_mv	AT swatidubey dosimetricevaluationofanalyticanisotropicalgorithmandacurosxbalgorithmusinginhousedevelopedheterogeneousthoraxphantomandhomogeneousslabphantomforstereotacticbodyradiationtherapytechnique AT priyushabagdare dosimetricevaluationofanalyticanisotropicalgorithmandacurosxbalgorithmusinginhousedevelopedheterogeneousthoraxphantomandhomogeneousslabphantomforstereotacticbodyradiationtherapytechnique AT sanjayghosh dosimetricevaluationofanalyticanisotropicalgorithmandacurosxbalgorithmusinginhousedevelopedheterogeneousthoraxphantomandhomogeneousslabphantomforstereotacticbodyradiationtherapytechnique
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Dosimetric evaluation of analytic anisotropic algorithm and Acuros XB algorithm using in-house developed heterogeneous thorax phantom and homogeneous slab phantom for stereotactic body radiation therapy technique

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