Association of betel nut with carcinogenesis: revisit with a clinical perspective.

Betel nut (BN), betel quid (BQ) and products derived from them are widely used as a socially endorsed masticatory product. The addictive nature of BN/BQ has resulted in its widespread usage making it the fourth most abused substance by humans. Progressively, several additives, including chewing toba...

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Autores principales:	Rajeshwar N Sharan, Ravi Mehrotra, Yashmin Choudhury, Kamlesh Asotra
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d1c59d45d64c4779ae888ea3a9802b73
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spelling	oai:doaj.org-article:d1c59d45d64c4779ae888ea3a9802b732021-11-18T07:08:58ZAssociation of betel nut with carcinogenesis: revisit with a clinical perspective.1932-620310.1371/journal.pone.0042759https://doaj.org/article/d1c59d45d64c4779ae888ea3a9802b732012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22912735/?tool=EBIhttps://doaj.org/toc/1932-6203Betel nut (BN), betel quid (BQ) and products derived from them are widely used as a socially endorsed masticatory product. The addictive nature of BN/BQ has resulted in its widespread usage making it the fourth most abused substance by humans. Progressively, several additives, including chewing tobacco, got added to simple BN preparations. This addictive practice has been shown to have strong etiological correlation with human susceptibility to cancer, particularly oral and oropharyngeal cancers.The PUBMED database was searched to retrieve all relevant published studies in English on BN and BQ, and its association with oral and oropharyngeal cancers. Only complete studies directly dealing with BN/BQ induced carcinogenesis using statistically valid and acceptable sample size were analyzed. Additional relevant information available from other sources was also considered.This systematic review attempts to put in perspective the consequences of this widespread habit of BN/BQ mastication, practiced by approximately 10% of the world population, on oral cancer with a clinical perspective. BN/BQ mastication seems to be significantly associated with susceptibility to oral and oropharyngeal cancers. Addition of tobacco to BN has been found to only marginally increase the cancer risk. Despite the widespread usage of BN/BQ and its strong association with human susceptibility to cancer, no serious strategy seems to exist to control this habit. The review, therefore, also looks at various preventive efforts being made by governments and highlights the multifaceted intervention strategies required to mitigate and/or control the habit of BN/BQ mastication.Rajeshwar N SharanRavi MehrotraYashmin ChoudhuryKamlesh AsotraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e42759 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rajeshwar N Sharan Ravi Mehrotra Yashmin Choudhury Kamlesh Asotra Association of betel nut with carcinogenesis: revisit with a clinical perspective.
description	Betel nut (BN), betel quid (BQ) and products derived from them are widely used as a socially endorsed masticatory product. The addictive nature of BN/BQ has resulted in its widespread usage making it the fourth most abused substance by humans. Progressively, several additives, including chewing tobacco, got added to simple BN preparations. This addictive practice has been shown to have strong etiological correlation with human susceptibility to cancer, particularly oral and oropharyngeal cancers.The PUBMED database was searched to retrieve all relevant published studies in English on BN and BQ, and its association with oral and oropharyngeal cancers. Only complete studies directly dealing with BN/BQ induced carcinogenesis using statistically valid and acceptable sample size were analyzed. Additional relevant information available from other sources was also considered.This systematic review attempts to put in perspective the consequences of this widespread habit of BN/BQ mastication, practiced by approximately 10% of the world population, on oral cancer with a clinical perspective. BN/BQ mastication seems to be significantly associated with susceptibility to oral and oropharyngeal cancers. Addition of tobacco to BN has been found to only marginally increase the cancer risk. Despite the widespread usage of BN/BQ and its strong association with human susceptibility to cancer, no serious strategy seems to exist to control this habit. The review, therefore, also looks at various preventive efforts being made by governments and highlights the multifaceted intervention strategies required to mitigate and/or control the habit of BN/BQ mastication.
format	article
author	Rajeshwar N Sharan Ravi Mehrotra Yashmin Choudhury Kamlesh Asotra
author_facet	Rajeshwar N Sharan Ravi Mehrotra Yashmin Choudhury Kamlesh Asotra
author_sort	Rajeshwar N Sharan
title	Association of betel nut with carcinogenesis: revisit with a clinical perspective.
title_short	Association of betel nut with carcinogenesis: revisit with a clinical perspective.
title_full	Association of betel nut with carcinogenesis: revisit with a clinical perspective.
title_fullStr	Association of betel nut with carcinogenesis: revisit with a clinical perspective.
title_full_unstemmed	Association of betel nut with carcinogenesis: revisit with a clinical perspective.
title_sort	association of betel nut with carcinogenesis: revisit with a clinical perspective.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/d1c59d45d64c4779ae888ea3a9802b73
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Association of betel nut with carcinogenesis: revisit with a clinical perspective.

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