Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy
Fuchs endothelial corneal dystrophy (FECD) is one of the most common reasons for corneal transplantation, and is known to cluster in families. Here, the authors discover new genetic loci associated with FECD with sex-specific effects and implications for disease mechanism.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/d1c65f3362014583bd22c5188abefc76 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:d1c65f3362014583bd22c5188abefc76 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:d1c65f3362014583bd22c5188abefc762021-12-02T14:40:21ZGenome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy10.1038/ncomms148982041-1723https://doaj.org/article/d1c65f3362014583bd22c5188abefc762017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14898https://doaj.org/toc/2041-1723Fuchs endothelial corneal dystrophy (FECD) is one of the most common reasons for corneal transplantation, and is known to cluster in families. Here, the authors discover new genetic loci associated with FECD with sex-specific effects and implications for disease mechanism.Natalie A. AfshariRobert P. IgoNathan J. MorrisDwight StambolianShiwani SharmaV. Lakshmi PulagamSteven DunnJohn F. StamlerBarbara J. TruittJacqueline RimmlerAbraham KuotChristopher R. CroasdaleXuejun QinKathryn P. BurdonS. Amer RiazuddinRichard MillsSonja KlebeMollie A. MinearJiagang ZhaoElmer BalajondaGeorge O. RosenwasserKeith H BaratzV. Vinod MoothaSanjay V. PatelSimon G. GregoryJoan E. Bailey-WilsonMarianne O. PriceFrancis W. PriceJamie E. CraigJohn H. FingertJohn D. GottschAnthony J. AldaveGordon K. KlintworthJonathan H. LassYi-Ju LiSudha K. IyengarNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Natalie A. Afshari Robert P. Igo Nathan J. Morris Dwight Stambolian Shiwani Sharma V. Lakshmi Pulagam Steven Dunn John F. Stamler Barbara J. Truitt Jacqueline Rimmler Abraham Kuot Christopher R. Croasdale Xuejun Qin Kathryn P. Burdon S. Amer Riazuddin Richard Mills Sonja Klebe Mollie A. Minear Jiagang Zhao Elmer Balajonda George O. Rosenwasser Keith H Baratz V. Vinod Mootha Sanjay V. Patel Simon G. Gregory Joan E. Bailey-Wilson Marianne O. Price Francis W. Price Jamie E. Craig John H. Fingert John D. Gottsch Anthony J. Aldave Gordon K. Klintworth Jonathan H. Lass Yi-Ju Li Sudha K. Iyengar Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy |
| description |
Fuchs endothelial corneal dystrophy (FECD) is one of the most common reasons for corneal transplantation, and is known to cluster in families. Here, the authors discover new genetic loci associated with FECD with sex-specific effects and implications for disease mechanism. |
| format |
article |
| author |
Natalie A. Afshari Robert P. Igo Nathan J. Morris Dwight Stambolian Shiwani Sharma V. Lakshmi Pulagam Steven Dunn John F. Stamler Barbara J. Truitt Jacqueline Rimmler Abraham Kuot Christopher R. Croasdale Xuejun Qin Kathryn P. Burdon S. Amer Riazuddin Richard Mills Sonja Klebe Mollie A. Minear Jiagang Zhao Elmer Balajonda George O. Rosenwasser Keith H Baratz V. Vinod Mootha Sanjay V. Patel Simon G. Gregory Joan E. Bailey-Wilson Marianne O. Price Francis W. Price Jamie E. Craig John H. Fingert John D. Gottsch Anthony J. Aldave Gordon K. Klintworth Jonathan H. Lass Yi-Ju Li Sudha K. Iyengar |
| author_facet |
Natalie A. Afshari Robert P. Igo Nathan J. Morris Dwight Stambolian Shiwani Sharma V. Lakshmi Pulagam Steven Dunn John F. Stamler Barbara J. Truitt Jacqueline Rimmler Abraham Kuot Christopher R. Croasdale Xuejun Qin Kathryn P. Burdon S. Amer Riazuddin Richard Mills Sonja Klebe Mollie A. Minear Jiagang Zhao Elmer Balajonda George O. Rosenwasser Keith H Baratz V. Vinod Mootha Sanjay V. Patel Simon G. Gregory Joan E. Bailey-Wilson Marianne O. Price Francis W. Price Jamie E. Craig John H. Fingert John D. Gottsch Anthony J. Aldave Gordon K. Klintworth Jonathan H. Lass Yi-Ju Li Sudha K. Iyengar |
| author_sort |
Natalie A. Afshari |
| title |
Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy |
| title_short |
Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy |
| title_full |
Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy |
| title_fullStr |
Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy |
| title_full_unstemmed |
Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy |
| title_sort |
genome-wide association study identifies three novel loci in fuchs endothelial corneal dystrophy |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/d1c65f3362014583bd22c5188abefc76 |
| work_keys_str_mv |
AT natalieaafshari genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT robertpigo genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT nathanjmorris genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT dwightstambolian genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT shiwanisharma genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT vlakshmipulagam genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT stevendunn genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT johnfstamler genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT barbarajtruitt genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT jacquelinerimmler genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT abrahamkuot genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT christopherrcroasdale genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT xuejunqin genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT kathrynpburdon genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT samerriazuddin genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT richardmills genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT sonjaklebe genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT mollieaminear genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT jiagangzhao genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT elmerbalajonda genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT georgeorosenwasser genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT keithhbaratz genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT vvinodmootha genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT sanjayvpatel genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT simonggregory genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT joanebaileywilson genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT marianneoprice genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT franciswprice genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT jamieecraig genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT johnhfingert genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT johndgottsch genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT anthonyjaldave genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT gordonkklintworth genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT jonathanhlass genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT yijuli genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy AT sudhakiyengar genomewideassociationstudyidentifiesthreenovellociinfuchsendothelialcornealdystrophy |
| _version_ |
1718390325910700032 |