Stimulation of wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF)

Xiaoyu Zhang,1 Xiaoning Kang,2 Lijun Jin,1 Jie Bai,1 Wei Liu,1 Zunyi Wang1 1Third Ward of Tumor Surgery Department, Cangzhou Central Hospital, Cangzhou, Hebei Province, People’s Republic of China; 2Third Ward of Ultrasound Department, Cangzhou Central Hospital, Cangzhou, Hebei Province, P...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhang X, Kang X, Jin L, Bai J, Liu W, Wang Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	bio-inspired hydrogels basic fibroblast growth factor gum arabic pectin wound healing Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d1c68e932fc94ba883b948668142fe7e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d1c68e932fc94ba883b948668142fe7e
record_format	dspace
spelling	oai:doaj.org-article:d1c68e932fc94ba883b948668142fe7e2021-12-02T08:29:26ZStimulation of wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF)1178-2013https://doaj.org/article/d1c68e932fc94ba883b948668142fe7e2018-07-01T00:00:00Zhttps://www.dovepress.com/stimulation-of-wound-healing-using-bioinspired-hydrogels-with-basic-fi-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xiaoyu Zhang,1 Xiaoning Kang,2 Lijun Jin,1 Jie Bai,1 Wei Liu,1 Zunyi Wang1 1Third Ward of Tumor Surgery Department, Cangzhou Central Hospital, Cangzhou, Hebei Province, People’s Republic of China; 2Third Ward of Ultrasound Department, Cangzhou Central Hospital, Cangzhou, Hebei Province, People’s Republic of China Introduction: The objective of this study is to stimulate wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF). Materials and methods: Inspired by the crosslinking mechanism in algae-based adhesives, hydrogels were fabricated with gum arabic, pectin, and Ca2+. The physical properties of the bioinspired hydrogels were characterized, and the in vitro release of bFGF was investigated. Then, the in vitro scratch assay for wound healing and in vivo wound healing experiment in a full-thickness excision wound model were performed for the bioinspired hydrogels with bFGF. Finally, histological examinations and organ toxicity tests were conducted to investigate the wound healing applications of the bioinspired hydrogels with bFGF. Results: The in vitro and in vivo results showed that the bioinspired hydrogels with bFGF could significantly enhance cell proliferation, wound re-epithelialization, collagen deposition, and contraction without any noticeable toxicity and inflammation compared with the hydrogels without bFGF and commercial wound healing products. Conclusion: These results suggest the potential application of bioinspired hydrogels with bFGF for wound healing. Keywords: bioinspired hydrogels, basic fibroblast growth factor, gum arabic, pectin, wound healingZhang XKang XJin LBai JLiu WWang ZDove Medical Pressarticlebio-inspired hydrogelsbasic fibroblast growth factorgum arabicpectinwound healingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 3897-3906 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	bio-inspired hydrogels basic fibroblast growth factor gum arabic pectin wound healing Medicine (General) R5-920
spellingShingle	bio-inspired hydrogels basic fibroblast growth factor gum arabic pectin wound healing Medicine (General) R5-920 Zhang X Kang X Jin L Bai J Liu W Wang Z Stimulation of wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF)
description	Xiaoyu Zhang,1 Xiaoning Kang,2 Lijun Jin,1 Jie Bai,1 Wei Liu,1 Zunyi Wang1 1Third Ward of Tumor Surgery Department, Cangzhou Central Hospital, Cangzhou, Hebei Province, People’s Republic of China; 2Third Ward of Ultrasound Department, Cangzhou Central Hospital, Cangzhou, Hebei Province, People’s Republic of China Introduction: The objective of this study is to stimulate wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF). Materials and methods: Inspired by the crosslinking mechanism in algae-based adhesives, hydrogels were fabricated with gum arabic, pectin, and Ca2+. The physical properties of the bioinspired hydrogels were characterized, and the in vitro release of bFGF was investigated. Then, the in vitro scratch assay for wound healing and in vivo wound healing experiment in a full-thickness excision wound model were performed for the bioinspired hydrogels with bFGF. Finally, histological examinations and organ toxicity tests were conducted to investigate the wound healing applications of the bioinspired hydrogels with bFGF. Results: The in vitro and in vivo results showed that the bioinspired hydrogels with bFGF could significantly enhance cell proliferation, wound re-epithelialization, collagen deposition, and contraction without any noticeable toxicity and inflammation compared with the hydrogels without bFGF and commercial wound healing products. Conclusion: These results suggest the potential application of bioinspired hydrogels with bFGF for wound healing. Keywords: bioinspired hydrogels, basic fibroblast growth factor, gum arabic, pectin, wound healing
format	article
author	Zhang X Kang X Jin L Bai J Liu W Wang Z
author_facet	Zhang X Kang X Jin L Bai J Liu W Wang Z
author_sort	Zhang X
title	Stimulation of wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF)
title_short	Stimulation of wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF)
title_full	Stimulation of wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF)
title_fullStr	Stimulation of wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF)
title_full_unstemmed	Stimulation of wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF)
title_sort	stimulation of wound healing using bioinspired hydrogels with basic fibroblast growth factor (bfgf)
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/d1c68e932fc94ba883b948668142fe7e
work_keys_str_mv	AT zhangx stimulationofwoundhealingusingbioinspiredhydrogelswithbasicfibroblastgrowthfactorbfgf AT kangx stimulationofwoundhealingusingbioinspiredhydrogelswithbasicfibroblastgrowthfactorbfgf AT jinl stimulationofwoundhealingusingbioinspiredhydrogelswithbasicfibroblastgrowthfactorbfgf AT baij stimulationofwoundhealingusingbioinspiredhydrogelswithbasicfibroblastgrowthfactorbfgf AT liuw stimulationofwoundhealingusingbioinspiredhydrogelswithbasicfibroblastgrowthfactorbfgf AT wangz stimulationofwoundhealingusingbioinspiredhydrogelswithbasicfibroblastgrowthfactorbfgf
_version_	1718398509840859136

Stimulation of wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF)

Ejemplares similares