Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress

Cyclins A2 and E1 are known to regulate the cell cycle by promoting S phase entry and progression. Here, they identify an aggressive hepatocellular carcinoma subgroup exhibiting cyclin activation through various mechanisms and find this subgroup to display replication stress-induced structural rearr...

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Autores principales:	Quentin Bayard, Léa Meunier, Camille Peneau, Victor Renault, Jayendra Shinde, Jean-Charles Nault, Iadh Mami, Gabrielle Couchy, Giuliana Amaddeo, Emmanuel Tubacher, Delphine Bacq, Vincent Meyer, Tiziana La Bella, Audrey Debaillon-Vesque, Paulette Bioulac-Sage, Olivier Seror, Jean-Frédéric Blanc, Julien Calderaro, Jean-François Deleuze, Sandrine Imbeaud, Jessica Zucman-Rossi, Eric Letouzé
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d1c71c5d3832437783153fd87d02ea45
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spelling	oai:doaj.org-article:d1c71c5d3832437783153fd87d02ea452021-12-02T16:49:38ZCyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress10.1038/s41467-018-07552-92041-1723https://doaj.org/article/d1c71c5d3832437783153fd87d02ea452018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07552-9https://doaj.org/toc/2041-1723Cyclins A2 and E1 are known to regulate the cell cycle by promoting S phase entry and progression. Here, they identify an aggressive hepatocellular carcinoma subgroup exhibiting cyclin activation through various mechanisms and find this subgroup to display replication stress-induced structural rearrangements frequently activating TERT promoter.Quentin BayardLéa MeunierCamille PeneauVictor RenaultJayendra ShindeJean-Charles NaultIadh MamiGabrielle CouchyGiuliana AmaddeoEmmanuel TubacherDelphine BacqVincent MeyerTiziana La BellaAudrey Debaillon-VesquePaulette Bioulac-SageOlivier SerorJean-Frédéric BlancJulien CalderaroJean-François DeleuzeSandrine ImbeaudJessica Zucman-RossiEric LetouzéNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Quentin Bayard Léa Meunier Camille Peneau Victor Renault Jayendra Shinde Jean-Charles Nault Iadh Mami Gabrielle Couchy Giuliana Amaddeo Emmanuel Tubacher Delphine Bacq Vincent Meyer Tiziana La Bella Audrey Debaillon-Vesque Paulette Bioulac-Sage Olivier Seror Jean-Frédéric Blanc Julien Calderaro Jean-François Deleuze Sandrine Imbeaud Jessica Zucman-Rossi Eric Letouzé Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress
description	Cyclins A2 and E1 are known to regulate the cell cycle by promoting S phase entry and progression. Here, they identify an aggressive hepatocellular carcinoma subgroup exhibiting cyclin activation through various mechanisms and find this subgroup to display replication stress-induced structural rearrangements frequently activating TERT promoter.
format	article
author	Quentin Bayard Léa Meunier Camille Peneau Victor Renault Jayendra Shinde Jean-Charles Nault Iadh Mami Gabrielle Couchy Giuliana Amaddeo Emmanuel Tubacher Delphine Bacq Vincent Meyer Tiziana La Bella Audrey Debaillon-Vesque Paulette Bioulac-Sage Olivier Seror Jean-Frédéric Blanc Julien Calderaro Jean-François Deleuze Sandrine Imbeaud Jessica Zucman-Rossi Eric Letouzé
author_facet	Quentin Bayard Léa Meunier Camille Peneau Victor Renault Jayendra Shinde Jean-Charles Nault Iadh Mami Gabrielle Couchy Giuliana Amaddeo Emmanuel Tubacher Delphine Bacq Vincent Meyer Tiziana La Bella Audrey Debaillon-Vesque Paulette Bioulac-Sage Olivier Seror Jean-Frédéric Blanc Julien Calderaro Jean-François Deleuze Sandrine Imbeaud Jessica Zucman-Rossi Eric Letouzé
author_sort	Quentin Bayard
title	Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress
title_short	Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress
title_full	Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress
title_fullStr	Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress
title_full_unstemmed	Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress
title_sort	cyclin a2/e1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d1c71c5d3832437783153fd87d02ea45
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Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress

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