Diagnosing sarcopenia and myosteatosis based on chest computed tomography images in healthy Chinese adults

Abstract Background Measuring muscle mass and muscle quality based on chest Computed Tomography (CT) images would facilitate sarcopenia and myosteatosis research. We aimed (1) to measure muscle mass and myosteatosis based on chest CT images at the 12th thoracic vertebra level and compare the relevan...

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Autores principales:	Lingling Tan, Guiyi Ji, Ting Bao, Hongbo Fu, Ling Yang, Ming Yang
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Muscle wasting Muscle depletion Skeletal muscle mass Computed Tomography Fat infiltration Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/d1c8056322654da6846b01fd6c0b0709
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spelling	oai:doaj.org-article:d1c8056322654da6846b01fd6c0b07092021-11-07T12:14:45ZDiagnosing sarcopenia and myosteatosis based on chest computed tomography images in healthy Chinese adults10.1186/s13244-021-01106-21869-4101https://doaj.org/article/d1c8056322654da6846b01fd6c0b07092021-11-01T00:00:00Zhttps://doi.org/10.1186/s13244-021-01106-2https://doaj.org/toc/1869-4101Abstract Background Measuring muscle mass and muscle quality based on chest Computed Tomography (CT) images would facilitate sarcopenia and myosteatosis research. We aimed (1) to measure muscle mass and myosteatosis based on chest CT images at the 12th thoracic vertebra level and compare the relevant indicators with whole-body skeletal muscle mass (BSM) and whole-body fat mass (BFM) measured by bioelectrical impedance analysis; and (2) to determine the cut-off points of these indicators for diagnosing sarcopenia or myosteatosis in healthy Chinese adults. Methods Chest CT images were analyzed using a segmentation software. Skeletal muscle area (SMA), skeletal muscle radiodensity (SMD), and intermuscular adiposity tissue (IMAT) were measured. Skeletal muscle indices (SMIs) and IMAT/SMA ratio were calculated. Results We included 569 participants. SMA, SMA/height2, and SMA/BMI were strongly and positively correlated with BSM (r = 0.90, 0.72, and 0.69, respectively, all p < 0.001); whereas SMA/weight was moderately and positively correlated with BSM (r = 0.38, p < 0.001). IMAT and IMAT/SMA were strongly and positively correlated with BFM (r = 0.67 and 0.58, respectively, both p < 0.001). SMD was moderately and negatively correlated with BFM (r = − 0.40, p < 0.001). We suggest SMA/height2 (< 25.75 cm2/m2 in men and < 20.16 cm2/m2 in women) for diagnosing sarcopenia and SMD (< 37.42 HU in men and < 33.17 HU in women) or IMAT (> 8.72 cm2 in men and > 4.58 cm2 in women) for diagnosing myosteatosis. Conclusions Muscle mass indicators (SMA and SMIs) and muscle quality indicators (SMD, IMAT, and IMAT/SMA) measured by chest CT images are valuable for diagnosing sarcopenia and myosteatosis, respectively.Lingling TanGuiyi JiTing BaoHongbo FuLing YangMing YangSpringerOpenarticleMuscle wastingMuscle depletionSkeletal muscle massComputed TomographyFat infiltrationMedical physics. Medical radiology. Nuclear medicineR895-920ENInsights into Imaging, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Muscle wasting Muscle depletion Skeletal muscle mass Computed Tomography Fat infiltration Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	Muscle wasting Muscle depletion Skeletal muscle mass Computed Tomography Fat infiltration Medical physics. Medical radiology. Nuclear medicine R895-920 Lingling Tan Guiyi Ji Ting Bao Hongbo Fu Ling Yang Ming Yang Diagnosing sarcopenia and myosteatosis based on chest computed tomography images in healthy Chinese adults
description	Abstract Background Measuring muscle mass and muscle quality based on chest Computed Tomography (CT) images would facilitate sarcopenia and myosteatosis research. We aimed (1) to measure muscle mass and myosteatosis based on chest CT images at the 12th thoracic vertebra level and compare the relevant indicators with whole-body skeletal muscle mass (BSM) and whole-body fat mass (BFM) measured by bioelectrical impedance analysis; and (2) to determine the cut-off points of these indicators for diagnosing sarcopenia or myosteatosis in healthy Chinese adults. Methods Chest CT images were analyzed using a segmentation software. Skeletal muscle area (SMA), skeletal muscle radiodensity (SMD), and intermuscular adiposity tissue (IMAT) were measured. Skeletal muscle indices (SMIs) and IMAT/SMA ratio were calculated. Results We included 569 participants. SMA, SMA/height2, and SMA/BMI were strongly and positively correlated with BSM (r = 0.90, 0.72, and 0.69, respectively, all p < 0.001); whereas SMA/weight was moderately and positively correlated with BSM (r = 0.38, p < 0.001). IMAT and IMAT/SMA were strongly and positively correlated with BFM (r = 0.67 and 0.58, respectively, both p < 0.001). SMD was moderately and negatively correlated with BFM (r = − 0.40, p < 0.001). We suggest SMA/height2 (< 25.75 cm2/m2 in men and < 20.16 cm2/m2 in women) for diagnosing sarcopenia and SMD (< 37.42 HU in men and < 33.17 HU in women) or IMAT (> 8.72 cm2 in men and > 4.58 cm2 in women) for diagnosing myosteatosis. Conclusions Muscle mass indicators (SMA and SMIs) and muscle quality indicators (SMD, IMAT, and IMAT/SMA) measured by chest CT images are valuable for diagnosing sarcopenia and myosteatosis, respectively.
format	article
author	Lingling Tan Guiyi Ji Ting Bao Hongbo Fu Ling Yang Ming Yang
author_facet	Lingling Tan Guiyi Ji Ting Bao Hongbo Fu Ling Yang Ming Yang
author_sort	Lingling Tan
title	Diagnosing sarcopenia and myosteatosis based on chest computed tomography images in healthy Chinese adults
title_short	Diagnosing sarcopenia and myosteatosis based on chest computed tomography images in healthy Chinese adults
title_full	Diagnosing sarcopenia and myosteatosis based on chest computed tomography images in healthy Chinese adults
title_fullStr	Diagnosing sarcopenia and myosteatosis based on chest computed tomography images in healthy Chinese adults
title_full_unstemmed	Diagnosing sarcopenia and myosteatosis based on chest computed tomography images in healthy Chinese adults
title_sort	diagnosing sarcopenia and myosteatosis based on chest computed tomography images in healthy chinese adults
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/d1c8056322654da6846b01fd6c0b0709
work_keys_str_mv	AT linglingtan diagnosingsarcopeniaandmyosteatosisbasedonchestcomputedtomographyimagesinhealthychineseadults AT guiyiji diagnosingsarcopeniaandmyosteatosisbasedonchestcomputedtomographyimagesinhealthychineseadults AT tingbao diagnosingsarcopeniaandmyosteatosisbasedonchestcomputedtomographyimagesinhealthychineseadults AT hongbofu diagnosingsarcopeniaandmyosteatosisbasedonchestcomputedtomographyimagesinhealthychineseadults AT lingyang diagnosingsarcopeniaandmyosteatosisbasedonchestcomputedtomographyimagesinhealthychineseadults AT mingyang diagnosingsarcopeniaandmyosteatosisbasedonchestcomputedtomographyimagesinhealthychineseadults
_version_	1718443517380919296

Diagnosing sarcopenia and myosteatosis based on chest computed tomography images in healthy Chinese adults

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