Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

Memory B cells are important for protecting the host from pathogen rechallenge, but their properties and locations remain ill-defined. Here the authors show, using single-cell transcriptomics and repertoire analyses, that mouse spleen and bone marrow host distinct populations of isotype-switched mem...

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Autores principales:	René Riedel, Richard Addo, Marta Ferreira-Gomes, Gitta Anne Heinz, Frederik Heinrich, Jannis Kummer, Victor Greiff, Daniel Schulz, Cora Klaeden, Rebecca Cornelis, Ulrike Menzel, Stefan Kröger, Ulrik Stervbo, Ralf Köhler, Claudia Haftmann, Silvia Kühnel, Katrin Lehmann, Patrick Maschmeyer, Mairi McGrath, Sandra Naundorf, Stefanie Hahne, Özen Sercan-Alp, Francesco Siracusa, Jonathan Stefanowski, Melanie Weber, Kerstin Westendorf, Jakob Zimmermann, Anja E. Hauser, Sai T. Reddy, Pawel Durek, Hyun-Dong Chang, Mir-Farzin Mashreghi, Andreas Radbruch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d1c99a7f8c7f4d7ab186f53fdfc1db4e
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spelling	oai:doaj.org-article:d1c99a7f8c7f4d7ab186f53fdfc1db4e2021-12-02T15:52:45ZDiscrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow10.1038/s41467-020-16464-62041-1723https://doaj.org/article/d1c99a7f8c7f4d7ab186f53fdfc1db4e2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16464-6https://doaj.org/toc/2041-1723Memory B cells are important for protecting the host from pathogen rechallenge, but their properties and locations remain ill-defined. Here the authors show, using single-cell transcriptomics and repertoire analyses, that mouse spleen and bone marrow host distinct populations of isotype-switched memory B cells to potentially optimize for rapid recall responses.René RiedelRichard AddoMarta Ferreira-GomesGitta Anne HeinzFrederik HeinrichJannis KummerVictor GreiffDaniel SchulzCora KlaedenRebecca CornelisUlrike MenzelStefan KrögerUlrik StervboRalf KöhlerClaudia HaftmannSilvia KühnelKatrin LehmannPatrick MaschmeyerMairi McGrathSandra NaundorfStefanie HahneÖzen Sercan-AlpFrancesco SiracusaJonathan StefanowskiMelanie WeberKerstin WestendorfJakob ZimmermannAnja E. HauserSai T. ReddyPawel DurekHyun-Dong ChangMir-Farzin MashreghiAndreas RadbruchNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q René Riedel Richard Addo Marta Ferreira-Gomes Gitta Anne Heinz Frederik Heinrich Jannis Kummer Victor Greiff Daniel Schulz Cora Klaeden Rebecca Cornelis Ulrike Menzel Stefan Kröger Ulrik Stervbo Ralf Köhler Claudia Haftmann Silvia Kühnel Katrin Lehmann Patrick Maschmeyer Mairi McGrath Sandra Naundorf Stefanie Hahne Özen Sercan-Alp Francesco Siracusa Jonathan Stefanowski Melanie Weber Kerstin Westendorf Jakob Zimmermann Anja E. Hauser Sai T. Reddy Pawel Durek Hyun-Dong Chang Mir-Farzin Mashreghi Andreas Radbruch Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow
description	Memory B cells are important for protecting the host from pathogen rechallenge, but their properties and locations remain ill-defined. Here the authors show, using single-cell transcriptomics and repertoire analyses, that mouse spleen and bone marrow host distinct populations of isotype-switched memory B cells to potentially optimize for rapid recall responses.
format	article
author	René Riedel Richard Addo Marta Ferreira-Gomes Gitta Anne Heinz Frederik Heinrich Jannis Kummer Victor Greiff Daniel Schulz Cora Klaeden Rebecca Cornelis Ulrike Menzel Stefan Kröger Ulrik Stervbo Ralf Köhler Claudia Haftmann Silvia Kühnel Katrin Lehmann Patrick Maschmeyer Mairi McGrath Sandra Naundorf Stefanie Hahne Özen Sercan-Alp Francesco Siracusa Jonathan Stefanowski Melanie Weber Kerstin Westendorf Jakob Zimmermann Anja E. Hauser Sai T. Reddy Pawel Durek Hyun-Dong Chang Mir-Farzin Mashreghi Andreas Radbruch
author_facet	René Riedel Richard Addo Marta Ferreira-Gomes Gitta Anne Heinz Frederik Heinrich Jannis Kummer Victor Greiff Daniel Schulz Cora Klaeden Rebecca Cornelis Ulrike Menzel Stefan Kröger Ulrik Stervbo Ralf Köhler Claudia Haftmann Silvia Kühnel Katrin Lehmann Patrick Maschmeyer Mairi McGrath Sandra Naundorf Stefanie Hahne Özen Sercan-Alp Francesco Siracusa Jonathan Stefanowski Melanie Weber Kerstin Westendorf Jakob Zimmermann Anja E. Hauser Sai T. Reddy Pawel Durek Hyun-Dong Chang Mir-Farzin Mashreghi Andreas Radbruch
author_sort	René Riedel
title	Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow
title_short	Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow
title_full	Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow
title_fullStr	Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow
title_full_unstemmed	Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow
title_sort	discrete populations of isotype-switched memory b lymphocytes are maintained in murine spleen and bone marrow
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d1c99a7f8c7f4d7ab186f53fdfc1db4e
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Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

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