Association of serum retinol binding protein 4 with atherogenic dyslipidemia in morbid obese patients.

Retinol binding protein 4 (RBP4) is an adipokine that may contribute to the development of insulin resistance. However, how this adipokine is affected and its possible involvement in lipid metabolism in obese patients with varying degrees of insulin resistance is yet to be determined. A total of 299...

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Autores principales:	Milagros Rocha, Celia Bañuls, Lorena Bellod, Susana Rovira-Llopis, Carlos Morillas, Eva Solá, Víctor M Víctor, Antonio Hernández-Mijares
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d1cc3d72e785445292de6303992b12c9
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spelling	oai:doaj.org-article:d1cc3d72e785445292de6303992b12c92021-11-18T08:48:31ZAssociation of serum retinol binding protein 4 with atherogenic dyslipidemia in morbid obese patients.1932-620310.1371/journal.pone.0078670https://doaj.org/article/d1cc3d72e785445292de6303992b12c92013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223837/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Retinol binding protein 4 (RBP4) is an adipokine that may contribute to the development of insulin resistance. However, how this adipokine is affected and its possible involvement in lipid metabolism in obese patients with varying degrees of insulin resistance is yet to be determined. A total of 299 middle-aged morbid obese patients (BMI>40 kg/m(2)) were divided in euglycemic, metabolic syndrome or type 2 diabetic. Anthropometric measurements, biochemical variables and systemic RBP4 levels were determined. RBP4 levels were significantly higher in patients with metabolic syndrome and type 2 diabetes than in euglycemic subjects (42.9±14.6; 42.3±17.0 and 37.4±11.7 µg/ml, respectively) and correlated with triglycerides but not with those of HOMA-IR in the whole population. The multivariate regression model revealed that triglycerides were the strongest predictor of systemic RBP4 levels. Analysis of lipoprotein subfractions in a subpopulation of 80 subjects showed an altered profile of insulin resistant states characterized by higher VLDL, sdLDL and small HDL percentages and lower large HDL percentage. Although RBP4 levels correlated significantly with LDL particle size and small HDL percentage, the latter parameter was independently associated only with RBP4. Our study reveals that systemic RBP4 levels could play an important role in lipid metabolism in morbid obesity, increasing triglyceride levels and contributing to the formation of small HDL.Milagros RochaCelia BañulsLorena BellodSusana Rovira-LlopisCarlos MorillasEva SoláVíctor M VíctorAntonio Hernández-MijaresPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e78670 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Milagros Rocha Celia Bañuls Lorena Bellod Susana Rovira-Llopis Carlos Morillas Eva Solá Víctor M Víctor Antonio Hernández-Mijares Association of serum retinol binding protein 4 with atherogenic dyslipidemia in morbid obese patients.
description	Retinol binding protein 4 (RBP4) is an adipokine that may contribute to the development of insulin resistance. However, how this adipokine is affected and its possible involvement in lipid metabolism in obese patients with varying degrees of insulin resistance is yet to be determined. A total of 299 middle-aged morbid obese patients (BMI>40 kg/m(2)) were divided in euglycemic, metabolic syndrome or type 2 diabetic. Anthropometric measurements, biochemical variables and systemic RBP4 levels were determined. RBP4 levels were significantly higher in patients with metabolic syndrome and type 2 diabetes than in euglycemic subjects (42.9±14.6; 42.3±17.0 and 37.4±11.7 µg/ml, respectively) and correlated with triglycerides but not with those of HOMA-IR in the whole population. The multivariate regression model revealed that triglycerides were the strongest predictor of systemic RBP4 levels. Analysis of lipoprotein subfractions in a subpopulation of 80 subjects showed an altered profile of insulin resistant states characterized by higher VLDL, sdLDL and small HDL percentages and lower large HDL percentage. Although RBP4 levels correlated significantly with LDL particle size and small HDL percentage, the latter parameter was independently associated only with RBP4. Our study reveals that systemic RBP4 levels could play an important role in lipid metabolism in morbid obesity, increasing triglyceride levels and contributing to the formation of small HDL.
format	article
author	Milagros Rocha Celia Bañuls Lorena Bellod Susana Rovira-Llopis Carlos Morillas Eva Solá Víctor M Víctor Antonio Hernández-Mijares
author_facet	Milagros Rocha Celia Bañuls Lorena Bellod Susana Rovira-Llopis Carlos Morillas Eva Solá Víctor M Víctor Antonio Hernández-Mijares
author_sort	Milagros Rocha
title	Association of serum retinol binding protein 4 with atherogenic dyslipidemia in morbid obese patients.
title_short	Association of serum retinol binding protein 4 with atherogenic dyslipidemia in morbid obese patients.
title_full	Association of serum retinol binding protein 4 with atherogenic dyslipidemia in morbid obese patients.
title_fullStr	Association of serum retinol binding protein 4 with atherogenic dyslipidemia in morbid obese patients.
title_full_unstemmed	Association of serum retinol binding protein 4 with atherogenic dyslipidemia in morbid obese patients.
title_sort	association of serum retinol binding protein 4 with atherogenic dyslipidemia in morbid obese patients.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d1cc3d72e785445292de6303992b12c9
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Association of serum retinol binding protein 4 with atherogenic dyslipidemia in morbid obese patients.

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