Different Associated Factors of Subjective Cognitive Complaints in Patients With Early- and Late-Onset Parkinson's Disease

Background: Subjective cognitive complaints (SCCs), which are associated with a higher risk of cognitive decline, are widespread in the patients with Parkinson's disease (PD). The previous studies have reported inconsistent factors related to SCCs in the patients with late-onset PD (LOPD), and...

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Autores principales:	Yi Xiao, Ruwei Ou, Tianmi Yang, Kuncheng Liu, Qianqian Wei, Yanbing Hou, Lingyu Zhang, Junyu Lin, Huifang Shang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Parkinson's disease subjective cognitive complaints non-motor symptoms early-onset Parkinson's disease (EOPD) mood disorder Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d1cc6427e8b446538edf1fa91c0d65ae
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spelling	oai:doaj.org-article:d1cc6427e8b446538edf1fa91c0d65ae2021-11-30T12:38:54ZDifferent Associated Factors of Subjective Cognitive Complaints in Patients With Early- and Late-Onset Parkinson's Disease1664-229510.3389/fneur.2021.749471https://doaj.org/article/d1cc6427e8b446538edf1fa91c0d65ae2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.749471/fullhttps://doaj.org/toc/1664-2295Background: Subjective cognitive complaints (SCCs), which are associated with a higher risk of cognitive decline, are widespread in the patients with Parkinson's disease (PD). The previous studies have reported inconsistent factors related to SCCs in the patients with late-onset PD (LOPD), and there is limited information on SCCs in the patients with early-onset PD (EOPD).Objective: We aimed to investigate the factors associated with SCCs in the drug-naïve patients with EOPD and LOPD without cognitive impairment.Methods: This cross-sectional study included 332 drug-naïve patients with PD, among whom 134 were EOPD and 198 were LOPD. Motor and non-motor symptoms, such as global objective cognitive status, depression, anxiety, apathy, fatigue, sleep, rapid eye movement sleep behavior disorder, orthostatic hypotension, and excessive daytime sleepiness, were assessed.Results: Twenty-five (18.66%) patients with EOPD and 49 (24.74%) patients with LOPD reported SCCs. A multivariate binary logistic regression analysis revealed that older age at onset [odds ratio (OR) = 1.24, P = 0.002], higher apathy score (OR = 1.13, P = 0.003), and lower scores in the visuospatial/executive abilities (OR = 0.25, P < 0.001) and memory (OR = 0.50, P = 0.024) domains of the Montreal Cognitive Assessment were associated with a higher risk of SCCs in the EOPD group. Higher apathy (OR = 1.06, P = 0.011) and anxiety (OR = 1.14, P < 0.001) scores were associated with SCCs in the LOPD group.Conclusion: Subjective cognitive complaints are only associated with mood disorders in patients with LOPD. In addition, SCCs may reflect subthreshold cognitive impairment in the patients with EOPD.Yi XiaoRuwei OuTianmi YangKuncheng LiuQianqian WeiYanbing HouLingyu ZhangJunyu LinHuifang ShangFrontiers Media S.A.articleParkinson's diseasesubjective cognitive complaintsnon-motor symptomsearly-onset Parkinson's disease (EOPD)mood disorderNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson's disease subjective cognitive complaints non-motor symptoms early-onset Parkinson's disease (EOPD) mood disorder Neurology. Diseases of the nervous system RC346-429
spellingShingle	Parkinson's disease subjective cognitive complaints non-motor symptoms early-onset Parkinson's disease (EOPD) mood disorder Neurology. Diseases of the nervous system RC346-429 Yi Xiao Ruwei Ou Tianmi Yang Kuncheng Liu Qianqian Wei Yanbing Hou Lingyu Zhang Junyu Lin Huifang Shang Different Associated Factors of Subjective Cognitive Complaints in Patients With Early- and Late-Onset Parkinson's Disease
description	Background: Subjective cognitive complaints (SCCs), which are associated with a higher risk of cognitive decline, are widespread in the patients with Parkinson's disease (PD). The previous studies have reported inconsistent factors related to SCCs in the patients with late-onset PD (LOPD), and there is limited information on SCCs in the patients with early-onset PD (EOPD).Objective: We aimed to investigate the factors associated with SCCs in the drug-naïve patients with EOPD and LOPD without cognitive impairment.Methods: This cross-sectional study included 332 drug-naïve patients with PD, among whom 134 were EOPD and 198 were LOPD. Motor and non-motor symptoms, such as global objective cognitive status, depression, anxiety, apathy, fatigue, sleep, rapid eye movement sleep behavior disorder, orthostatic hypotension, and excessive daytime sleepiness, were assessed.Results: Twenty-five (18.66%) patients with EOPD and 49 (24.74%) patients with LOPD reported SCCs. A multivariate binary logistic regression analysis revealed that older age at onset [odds ratio (OR) = 1.24, P = 0.002], higher apathy score (OR = 1.13, P = 0.003), and lower scores in the visuospatial/executive abilities (OR = 0.25, P < 0.001) and memory (OR = 0.50, P = 0.024) domains of the Montreal Cognitive Assessment were associated with a higher risk of SCCs in the EOPD group. Higher apathy (OR = 1.06, P = 0.011) and anxiety (OR = 1.14, P < 0.001) scores were associated with SCCs in the LOPD group.Conclusion: Subjective cognitive complaints are only associated with mood disorders in patients with LOPD. In addition, SCCs may reflect subthreshold cognitive impairment in the patients with EOPD.
format	article
author	Yi Xiao Ruwei Ou Tianmi Yang Kuncheng Liu Qianqian Wei Yanbing Hou Lingyu Zhang Junyu Lin Huifang Shang
author_facet	Yi Xiao Ruwei Ou Tianmi Yang Kuncheng Liu Qianqian Wei Yanbing Hou Lingyu Zhang Junyu Lin Huifang Shang
author_sort	Yi Xiao
title	Different Associated Factors of Subjective Cognitive Complaints in Patients With Early- and Late-Onset Parkinson's Disease
title_short	Different Associated Factors of Subjective Cognitive Complaints in Patients With Early- and Late-Onset Parkinson's Disease
title_full	Different Associated Factors of Subjective Cognitive Complaints in Patients With Early- and Late-Onset Parkinson's Disease
title_fullStr	Different Associated Factors of Subjective Cognitive Complaints in Patients With Early- and Late-Onset Parkinson's Disease
title_full_unstemmed	Different Associated Factors of Subjective Cognitive Complaints in Patients With Early- and Late-Onset Parkinson's Disease
title_sort	different associated factors of subjective cognitive complaints in patients with early- and late-onset parkinson's disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d1cc6427e8b446538edf1fa91c0d65ae
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Different Associated Factors of Subjective Cognitive Complaints in Patients With Early- and Late-Onset Parkinson's Disease

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