Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis

Background: The aim was to analyze, in vitro, four resin based composite systems (RBCs) immersed in saliva of leukemia patients before starting chemotherapy regiments. Material and methods: Saliva was collected from 20 patients (4 healthy patients, 16 leukemia patients). Resin disks were made for ea...

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Autores principales:	Alexandru Mester, Marioara Moldovan, Stanca Cuc, Ciprian Tomuleasa, Sergiu Pasca, Miuta Filip, Andra Piciu, Florin Onisor
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	leukemia oral health saliva dental composite resin-based composite Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d1d1715b65904688b8d3c6f4be6b4ab5
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spelling	oai:doaj.org-article:d1d1715b65904688b8d3c6f4be6b4ab52021-11-25T16:49:40ZCharacteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis10.3390/biomedicines91116182227-9059https://doaj.org/article/d1d1715b65904688b8d3c6f4be6b4ab52021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1618https://doaj.org/toc/2227-9059Background: The aim was to analyze, in vitro, four resin based composite systems (RBCs) immersed in saliva of leukemia patients before starting chemotherapy regiments. Material and methods: Saliva was collected from 20 patients (4 healthy patients, 16 leukemia patients). Resin disks were made for each RBC and were immersed in the acute leukemia (acute lymphocytic (ALL), acute myeloid (AML)), chronic leukemia (chronic lymphocytic (CLL), chronic myeloid (CML)), Artificial saliva and Control environment, and maintained for seven days. At the end of the experiment, the characteristics and the effective response of saliva from the studied salivas’ on RBCs was assessed using water sorption, water solubility, residual monomer and scanning electron microscopy (SEM). Data analysis was performed and a <i>p</i>-value under 0.05 was considered statistically significant. Results: The behaviour of RBCs in different immersion environments varies according to the characteristics of the RBCs. RBCs with a higher filler ratio have a lower water sorption. The solubility is also deteriorated by the types of organic matrix and filler; the results of solubility being inversely proportional on the scale of negative values compared to sorption values. Chromatograms of residual monomers showed the highest amount of unreacted monomers in ALL and AML, and the Control and artificial saliva environments had the smallest residual monomer peaks. Because of the low number of differences between the experimental conditions, we further considered that there were no important statistical differences between experimental conditions and analysed them as a single group. Conclusion: The influence of saliva on RBCs depends on the type of leukemia; acute leukemia influenced the most RBCs by changing their properties compared to chronic leukemia.Alexandru MesterMarioara MoldovanStanca CucCiprian TomuleasaSergiu PascaMiuta FilipAndra PiciuFlorin OnisorMDPI AGarticleleukemiaoral healthsalivadental compositeresin-based compositeBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1618, p 1618 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	leukemia oral health saliva dental composite resin-based composite Biology (General) QH301-705.5
spellingShingle	leukemia oral health saliva dental composite resin-based composite Biology (General) QH301-705.5 Alexandru Mester Marioara Moldovan Stanca Cuc Ciprian Tomuleasa Sergiu Pasca Miuta Filip Andra Piciu Florin Onisor Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis
description	Background: The aim was to analyze, in vitro, four resin based composite systems (RBCs) immersed in saliva of leukemia patients before starting chemotherapy regiments. Material and methods: Saliva was collected from 20 patients (4 healthy patients, 16 leukemia patients). Resin disks were made for each RBC and were immersed in the acute leukemia (acute lymphocytic (ALL), acute myeloid (AML)), chronic leukemia (chronic lymphocytic (CLL), chronic myeloid (CML)), Artificial saliva and Control environment, and maintained for seven days. At the end of the experiment, the characteristics and the effective response of saliva from the studied salivas’ on RBCs was assessed using water sorption, water solubility, residual monomer and scanning electron microscopy (SEM). Data analysis was performed and a <i>p</i>-value under 0.05 was considered statistically significant. Results: The behaviour of RBCs in different immersion environments varies according to the characteristics of the RBCs. RBCs with a higher filler ratio have a lower water sorption. The solubility is also deteriorated by the types of organic matrix and filler; the results of solubility being inversely proportional on the scale of negative values compared to sorption values. Chromatograms of residual monomers showed the highest amount of unreacted monomers in ALL and AML, and the Control and artificial saliva environments had the smallest residual monomer peaks. Because of the low number of differences between the experimental conditions, we further considered that there were no important statistical differences between experimental conditions and analysed them as a single group. Conclusion: The influence of saliva on RBCs depends on the type of leukemia; acute leukemia influenced the most RBCs by changing their properties compared to chronic leukemia.
format	article
author	Alexandru Mester Marioara Moldovan Stanca Cuc Ciprian Tomuleasa Sergiu Pasca Miuta Filip Andra Piciu Florin Onisor
author_facet	Alexandru Mester Marioara Moldovan Stanca Cuc Ciprian Tomuleasa Sergiu Pasca Miuta Filip Andra Piciu Florin Onisor
author_sort	Alexandru Mester
title	Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis
title_short	Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis
title_full	Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis
title_fullStr	Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis
title_full_unstemmed	Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis
title_sort	characteristics of dental resin-based composites in leukemia saliva: an in vitro analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d1d1715b65904688b8d3c6f4be6b4ab5
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Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis

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