Occurrence of Textile Dyes and Metals in Tunisian Textile Dyeing Effluent: Effects on Oxidative Stress Status and Histological Changes in Balb/c Mice

Although it is known that textile wastewater contains highly toxic contaminants whose effects in humans represent public health problems in several countries, studies involving mammal species are scarce. This study was aimed to evaluate the toxicity profile of 90-days oral administration of textile...

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Autores principales:	Nosra Methneni, Khawla Ezdini, Nouha Ben Abdeljelil, Joris Van Loco, Kathy Van den Houwe, Riheb Jabeur, Ons Fekih Sallem, Ahlem Jaziri, Mercedes Fernandez-Serrano, Nezar H. Khdary, Hedi Ben Mansour
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	textile dyeing effluent mice oxidative stress histopathology metals toxicity Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d1d34e1e0ef845c7bb1da7ea8f4dee12
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spelling	oai:doaj.org-article:d1d34e1e0ef845c7bb1da7ea8f4dee122021-11-25T17:57:57ZOccurrence of Textile Dyes and Metals in Tunisian Textile Dyeing Effluent: Effects on Oxidative Stress Status and Histological Changes in Balb/c Mice10.3390/ijms2222125681422-00671661-6596https://doaj.org/article/d1d34e1e0ef845c7bb1da7ea8f4dee122021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12568https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Although it is known that textile wastewater contains highly toxic contaminants whose effects in humans represent public health problems in several countries, studies involving mammal species are scarce. This study was aimed to evaluate the toxicity profile of 90-days oral administration of textile dyeing effluent (TDE) on oxidative stress status and histological changes of male mice. The TDE was collected from the textile plant of Monastir, Tunisia and evaluated for the metals, aromatic amines, and textile dyes using analytical approaches. Metal analysis by ICP-MS showed that the tested TDE exhibited very high levels of Cr, As, and Sr, which exceeded the wastewater emission limits prescribed by WHO and Tunisian authority. The screening of TDE through UPLC-MS/MS confirmed the presence of two textile dyes: a triphenylmethane dye (Crystal violet) and a disperse azo dye (Disperse yellow 3). Exposure to TDE significantly altered the malondialdehyde (MDA), Conjugated dienes (CDs), Sulfhydryl proteins (SHP) and catalase levels in the hepatic and renal tissues. Furthermore, histopathology observation showed that hepatocellular and renal lesions were induced by TDE exposure. The present study concluded that TDE may involve induction of oxidative stress which ensues in pathological lesions in several vital organs suggesting its high toxicity. Metals and textile dyes may be associated with the observed toxicological effects of the TDE. These pollutants, which may have seeped into surrounding rivers in Monastir city, can cause severe health malaise in wildlife and humans.Nosra MethneniKhawla EzdiniNouha Ben AbdeljelilJoris Van LocoKathy Van den HouweRiheb JabeurOns Fekih SallemAhlem JaziriMercedes Fernandez-SerranoNezar H. KhdaryHedi Ben MansourMDPI AGarticletextile dyeing effluentmiceoxidative stresshistopathologymetalstoxicityBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12568, p 12568 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	textile dyeing effluent mice oxidative stress histopathology metals toxicity Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	textile dyeing effluent mice oxidative stress histopathology metals toxicity Biology (General) QH301-705.5 Chemistry QD1-999 Nosra Methneni Khawla Ezdini Nouha Ben Abdeljelil Joris Van Loco Kathy Van den Houwe Riheb Jabeur Ons Fekih Sallem Ahlem Jaziri Mercedes Fernandez-Serrano Nezar H. Khdary Hedi Ben Mansour Occurrence of Textile Dyes and Metals in Tunisian Textile Dyeing Effluent: Effects on Oxidative Stress Status and Histological Changes in Balb/c Mice
description	Although it is known that textile wastewater contains highly toxic contaminants whose effects in humans represent public health problems in several countries, studies involving mammal species are scarce. This study was aimed to evaluate the toxicity profile of 90-days oral administration of textile dyeing effluent (TDE) on oxidative stress status and histological changes of male mice. The TDE was collected from the textile plant of Monastir, Tunisia and evaluated for the metals, aromatic amines, and textile dyes using analytical approaches. Metal analysis by ICP-MS showed that the tested TDE exhibited very high levels of Cr, As, and Sr, which exceeded the wastewater emission limits prescribed by WHO and Tunisian authority. The screening of TDE through UPLC-MS/MS confirmed the presence of two textile dyes: a triphenylmethane dye (Crystal violet) and a disperse azo dye (Disperse yellow 3). Exposure to TDE significantly altered the malondialdehyde (MDA), Conjugated dienes (CDs), Sulfhydryl proteins (SHP) and catalase levels in the hepatic and renal tissues. Furthermore, histopathology observation showed that hepatocellular and renal lesions were induced by TDE exposure. The present study concluded that TDE may involve induction of oxidative stress which ensues in pathological lesions in several vital organs suggesting its high toxicity. Metals and textile dyes may be associated with the observed toxicological effects of the TDE. These pollutants, which may have seeped into surrounding rivers in Monastir city, can cause severe health malaise in wildlife and humans.
format	article
author	Nosra Methneni Khawla Ezdini Nouha Ben Abdeljelil Joris Van Loco Kathy Van den Houwe Riheb Jabeur Ons Fekih Sallem Ahlem Jaziri Mercedes Fernandez-Serrano Nezar H. Khdary Hedi Ben Mansour
author_facet	Nosra Methneni Khawla Ezdini Nouha Ben Abdeljelil Joris Van Loco Kathy Van den Houwe Riheb Jabeur Ons Fekih Sallem Ahlem Jaziri Mercedes Fernandez-Serrano Nezar H. Khdary Hedi Ben Mansour
author_sort	Nosra Methneni
title	Occurrence of Textile Dyes and Metals in Tunisian Textile Dyeing Effluent: Effects on Oxidative Stress Status and Histological Changes in Balb/c Mice
title_short	Occurrence of Textile Dyes and Metals in Tunisian Textile Dyeing Effluent: Effects on Oxidative Stress Status and Histological Changes in Balb/c Mice
title_full	Occurrence of Textile Dyes and Metals in Tunisian Textile Dyeing Effluent: Effects on Oxidative Stress Status and Histological Changes in Balb/c Mice
title_fullStr	Occurrence of Textile Dyes and Metals in Tunisian Textile Dyeing Effluent: Effects on Oxidative Stress Status and Histological Changes in Balb/c Mice
title_full_unstemmed	Occurrence of Textile Dyes and Metals in Tunisian Textile Dyeing Effluent: Effects on Oxidative Stress Status and Histological Changes in Balb/c Mice
title_sort	occurrence of textile dyes and metals in tunisian textile dyeing effluent: effects on oxidative stress status and histological changes in balb/c mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d1d34e1e0ef845c7bb1da7ea8f4dee12
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Occurrence of Textile Dyes and Metals in Tunisian Textile Dyeing Effluent: Effects on Oxidative Stress Status and Histological Changes in Balb/c Mice

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