FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility

cAMP/PKA signalling plays important roles in physiology, but there are a lack of tools to spatially distinguish cAMP. Here the authors present a FRET-based cAMP biosensor they call CUTie that can directly compare cAMP signals at multiple subcellular sites and detect nanoscale heterogeneity in cAMP i...

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Autores principales:	Nicoletta C. Surdo, Marco Berrera, Andreas Koschinski, Marcella Brescia, Matias R. Machado, Carolyn Carr, Peter Wright, Julia Gorelik, Stefano Morotti, Eleonora Grandi, Donald M. Bers, Sergio Pantano, Manuela Zaccolo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d1d7f459cfec49df9245a86888c2a82a
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spelling	oai:doaj.org-article:d1d7f459cfec49df9245a86888c2a82a2021-12-02T15:38:49ZFRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility10.1038/ncomms150312041-1723https://doaj.org/article/d1d7f459cfec49df9245a86888c2a82a2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15031https://doaj.org/toc/2041-1723cAMP/PKA signalling plays important roles in physiology, but there are a lack of tools to spatially distinguish cAMP. Here the authors present a FRET-based cAMP biosensor they call CUTie that can directly compare cAMP signals at multiple subcellular sites and detect nanoscale heterogeneity in cAMP in cardiac myocytes.Nicoletta C. SurdoMarco BerreraAndreas KoschinskiMarcella BresciaMatias R. MachadoCarolyn CarrPeter WrightJulia GorelikStefano MorottiEleonora GrandiDonald M. BersSergio PantanoManuela ZaccoloNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicoletta C. Surdo Marco Berrera Andreas Koschinski Marcella Brescia Matias R. Machado Carolyn Carr Peter Wright Julia Gorelik Stefano Morotti Eleonora Grandi Donald M. Bers Sergio Pantano Manuela Zaccolo FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility
description	cAMP/PKA signalling plays important roles in physiology, but there are a lack of tools to spatially distinguish cAMP. Here the authors present a FRET-based cAMP biosensor they call CUTie that can directly compare cAMP signals at multiple subcellular sites and detect nanoscale heterogeneity in cAMP in cardiac myocytes.
format	article
author	Nicoletta C. Surdo Marco Berrera Andreas Koschinski Marcella Brescia Matias R. Machado Carolyn Carr Peter Wright Julia Gorelik Stefano Morotti Eleonora Grandi Donald M. Bers Sergio Pantano Manuela Zaccolo
author_facet	Nicoletta C. Surdo Marco Berrera Andreas Koschinski Marcella Brescia Matias R. Machado Carolyn Carr Peter Wright Julia Gorelik Stefano Morotti Eleonora Grandi Donald M. Bers Sergio Pantano Manuela Zaccolo
author_sort	Nicoletta C. Surdo
title	FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility
title_short	FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility
title_full	FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility
title_fullStr	FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility
title_full_unstemmed	FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility
title_sort	fret biosensor uncovers camp nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d1d7f459cfec49df9245a86888c2a82a
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FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility

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