Chemical modulation of M13 bacteriophage and its functional opportunities for nanomedicine
Woo-Jae Chung,1 Doe-Young Lee,1 So Young Yoo2,3 1College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Republic of Korea; 2BIO-IT Foundry Technology Institute, Pusan National University, Busan, Republic of Korea; 3Research Institute for Convergence of Biomedical Science and...
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Dove Medical Press
2014
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oai:doaj.org-article:d1d840bb862d4fefb1e04da8f9d6929d2021-12-02T07:13:44ZChemical modulation of M13 bacteriophage and its functional opportunities for nanomedicine1178-2013https://doaj.org/article/d1d840bb862d4fefb1e04da8f9d6929d2014-12-01T00:00:00Zhttp://www.dovepress.com/chemical-modulation-of-m13-bacteriophage-andnbspits-functional-opportu-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Woo-Jae Chung,1 Doe-Young Lee,1 So Young Yoo2,3 1College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Republic of Korea; 2BIO-IT Foundry Technology Institute, Pusan National University, Busan, Republic of Korea; 3Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea Abstract: M13 bacteriophage (phage) has emerged as an attractive bionanomaterial owing to its genetically tunable surface chemistry and its potential to self-assemble into hierarchical structures. Furthermore, because of its unique nanoscopic structure, phage has been proposed as a model system in soft condensed physics and as a biomimetic building block for structured functional materials. Genetic engineering of phage provides great opportunities to develop novel nanomaterials with functional surface peptide motifs; however, this biological approach is generally limited to peptides containing the 20 natural amino acids. To extend the scope of phage applications, strategies involving chemical modification have been employed to incorporate a wider range of functional groups, including synthetic chemical compounds. In this review, we introduce the design of chemoselective phage functionalization and discuss how such a strategy is combined with genetic engineering for a variety of medical applications, as reported in recent literature. Keywords: M13 bacteriophage, chemoselective modification, functionalization, biomimetic structure, bionanomaterialChung WJLee DYYoo SYDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 5825-5836 (2014) |
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DOAJ |
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DOAJ |
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Medicine (General) R5-920 |
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Medicine (General) R5-920 Chung WJ Lee DY Yoo SY Chemical modulation of M13 bacteriophage and its functional opportunities for nanomedicine |
| description |
Woo-Jae Chung,1 Doe-Young Lee,1 So Young Yoo2,3 1College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Republic of Korea; 2BIO-IT Foundry Technology Institute, Pusan National University, Busan, Republic of Korea; 3Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea Abstract: M13 bacteriophage (phage) has emerged as an attractive bionanomaterial owing to its genetically tunable surface chemistry and its potential to self-assemble into hierarchical structures. Furthermore, because of its unique nanoscopic structure, phage has been proposed as a model system in soft condensed physics and as a biomimetic building block for structured functional materials. Genetic engineering of phage provides great opportunities to develop novel nanomaterials with functional surface peptide motifs; however, this biological approach is generally limited to peptides containing the 20 natural amino acids. To extend the scope of phage applications, strategies involving chemical modification have been employed to incorporate a wider range of functional groups, including synthetic chemical compounds. In this review, we introduce the design of chemoselective phage functionalization and discuss how such a strategy is combined with genetic engineering for a variety of medical applications, as reported in recent literature. Keywords: M13 bacteriophage, chemoselective modification, functionalization, biomimetic structure, bionanomaterial |
| format |
article |
| author |
Chung WJ Lee DY Yoo SY |
| author_facet |
Chung WJ Lee DY Yoo SY |
| author_sort |
Chung WJ |
| title |
Chemical modulation of M13 bacteriophage and its functional opportunities for nanomedicine |
| title_short |
Chemical modulation of M13 bacteriophage and its functional opportunities for nanomedicine |
| title_full |
Chemical modulation of M13 bacteriophage and its functional opportunities for nanomedicine |
| title_fullStr |
Chemical modulation of M13 bacteriophage and its functional opportunities for nanomedicine |
| title_full_unstemmed |
Chemical modulation of M13 bacteriophage and its functional opportunities for nanomedicine |
| title_sort |
chemical modulation of m13 bacteriophage and its functional opportunities for nanomedicine |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/d1d840bb862d4fefb1e04da8f9d6929d |
| work_keys_str_mv |
AT chungwj chemicalmodulationofm13bacteriophageandnbspitsfunctionalopportunitiesfornanomedicine AT leedy chemicalmodulationofm13bacteriophageandnbspitsfunctionalopportunitiesfornanomedicine AT yoosy chemicalmodulationofm13bacteriophageandnbspitsfunctionalopportunitiesfornanomedicine |
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