Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing

Aberrant tissue repair may result in heterotopic ossification (HO), but how this process is regulated by local inflammatory responses is still unclear. Here the authors show, using a mouse burn/trauma model, that TGFβ-producing monocytes/macrophages at the injury site contribute to HO induction, whi...

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Autores principales:	Michael Sorkin, Amanda K. Huber, Charles Hwang, William F. Carson, Rajasree Menon, John Li, Kaetlin Vasquez, Chase Pagani, Nicole Patel, Shuli Li, Noelle D. Visser, Yashar Niknafs, Shawn Loder, Melissa Scola, Dylan Nycz, Katherine Gallagher, Laurie K. McCauley, Jiajia Xu, Aaron W. James, Shailesh Agarwal, Stephen Kunkel, Yuji Mishina, Benjamin Levi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d1da08c830104fc9b81a6525ff7ff86b
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spelling	oai:doaj.org-article:d1da08c830104fc9b81a6525ff7ff86b2021-12-02T15:39:23ZRegulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing10.1038/s41467-019-14172-42041-1723https://doaj.org/article/d1da08c830104fc9b81a6525ff7ff86b2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14172-4https://doaj.org/toc/2041-1723Aberrant tissue repair may result in heterotopic ossification (HO), but how this process is regulated by local inflammatory responses is still unclear. Here the authors show, using a mouse burn/trauma model, that TGFβ-producing monocytes/macrophages at the injury site contribute to HO induction, while CD47 activation helps antagonize this process.Michael SorkinAmanda K. HuberCharles HwangWilliam F. CarsonRajasree MenonJohn LiKaetlin VasquezChase PaganiNicole PatelShuli LiNoelle D. VisserYashar NiknafsShawn LoderMelissa ScolaDylan NyczKatherine GallagherLaurie K. McCauleyJiajia XuAaron W. JamesShailesh AgarwalStephen KunkelYuji MishinaBenjamin LeviNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Sorkin Amanda K. Huber Charles Hwang William F. Carson Rajasree Menon John Li Kaetlin Vasquez Chase Pagani Nicole Patel Shuli Li Noelle D. Visser Yashar Niknafs Shawn Loder Melissa Scola Dylan Nycz Katherine Gallagher Laurie K. McCauley Jiajia Xu Aaron W. James Shailesh Agarwal Stephen Kunkel Yuji Mishina Benjamin Levi Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing
description	Aberrant tissue repair may result in heterotopic ossification (HO), but how this process is regulated by local inflammatory responses is still unclear. Here the authors show, using a mouse burn/trauma model, that TGFβ-producing monocytes/macrophages at the injury site contribute to HO induction, while CD47 activation helps antagonize this process.
format	article
author	Michael Sorkin Amanda K. Huber Charles Hwang William F. Carson Rajasree Menon John Li Kaetlin Vasquez Chase Pagani Nicole Patel Shuli Li Noelle D. Visser Yashar Niknafs Shawn Loder Melissa Scola Dylan Nycz Katherine Gallagher Laurie K. McCauley Jiajia Xu Aaron W. James Shailesh Agarwal Stephen Kunkel Yuji Mishina Benjamin Levi
author_facet	Michael Sorkin Amanda K. Huber Charles Hwang William F. Carson Rajasree Menon John Li Kaetlin Vasquez Chase Pagani Nicole Patel Shuli Li Noelle D. Visser Yashar Niknafs Shawn Loder Melissa Scola Dylan Nycz Katherine Gallagher Laurie K. McCauley Jiajia Xu Aaron W. James Shailesh Agarwal Stephen Kunkel Yuji Mishina Benjamin Levi
author_sort	Michael Sorkin
title	Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing
title_short	Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing
title_full	Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing
title_fullStr	Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing
title_full_unstemmed	Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing
title_sort	regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d1da08c830104fc9b81a6525ff7ff86b
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Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing

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