Pathophysiology and Diagnosis of Coronary Functional Abnormalities

Approximately one-half of patients undergoing diagnostic coronary angiography for angina have no significant coronary atherosclerotic stenosis. This clinical condition has recently been described as ischaemia with non-obstructive coronary arteries (INOCA). Coronary functional abnormalities are centr...

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Autores principales:	Jun Takahashi, Akira Suda, Kensuke Nishimiya, Shigeo Godo, Satoshi Yasuda, Hiroaki Shimokawa
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/d1ddd6a0ce654bb089c1811bc45d807c
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spelling	oai:doaj.org-article:d1ddd6a0ce654bb089c1811bc45d807c2021-12-04T16:04:56ZPathophysiology and Diagnosis of Coronary Functional Abnormalities10.15420/ecr.2021.231758-37641758-3756https://doaj.org/article/d1ddd6a0ce654bb089c1811bc45d807c2021-09-01T00:00:00Zhttps://www.ecrjournal.com/articleindex/ecr.2021.23https://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764Approximately one-half of patients undergoing diagnostic coronary angiography for angina have no significant coronary atherosclerotic stenosis. This clinical condition has recently been described as ischaemia with non-obstructive coronary arteries (INOCA). Coronary functional abnormalities are central to the pathogenesis of INOCA, including epicardial coronary spasm and coronary microvascular dysfunction composed of a variable combination of increased vasoconstrictive reactivity and/or reduced vasodilator function. During the last decade – in INOCA patients in particular – evidence for the prognostic impact of coronary functional abnormalities has accumulated and various non-invasive and invasive diagnostic techniques have enabled the evaluation of coronary vasomotor function in a comprehensive manner. In this review, the authors briefly summarise the recent advances in the understanding of pathophysiology and diagnosis of epicardial coronary artery spasm and coronary microvascular dysfunction.Jun TakahashiAkira SudaKensuke NishimiyaShigeo GodoSatoshi YasudaHiroaki ShimokawaRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 16, Iss , Pp - (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Jun Takahashi Akira Suda Kensuke Nishimiya Shigeo Godo Satoshi Yasuda Hiroaki Shimokawa Pathophysiology and Diagnosis of Coronary Functional Abnormalities
description	Approximately one-half of patients undergoing diagnostic coronary angiography for angina have no significant coronary atherosclerotic stenosis. This clinical condition has recently been described as ischaemia with non-obstructive coronary arteries (INOCA). Coronary functional abnormalities are central to the pathogenesis of INOCA, including epicardial coronary spasm and coronary microvascular dysfunction composed of a variable combination of increased vasoconstrictive reactivity and/or reduced vasodilator function. During the last decade – in INOCA patients in particular – evidence for the prognostic impact of coronary functional abnormalities has accumulated and various non-invasive and invasive diagnostic techniques have enabled the evaluation of coronary vasomotor function in a comprehensive manner. In this review, the authors briefly summarise the recent advances in the understanding of pathophysiology and diagnosis of epicardial coronary artery spasm and coronary microvascular dysfunction.
format	article
author	Jun Takahashi Akira Suda Kensuke Nishimiya Shigeo Godo Satoshi Yasuda Hiroaki Shimokawa
author_facet	Jun Takahashi Akira Suda Kensuke Nishimiya Shigeo Godo Satoshi Yasuda Hiroaki Shimokawa
author_sort	Jun Takahashi
title	Pathophysiology and Diagnosis of Coronary Functional Abnormalities
title_short	Pathophysiology and Diagnosis of Coronary Functional Abnormalities
title_full	Pathophysiology and Diagnosis of Coronary Functional Abnormalities
title_fullStr	Pathophysiology and Diagnosis of Coronary Functional Abnormalities
title_full_unstemmed	Pathophysiology and Diagnosis of Coronary Functional Abnormalities
title_sort	pathophysiology and diagnosis of coronary functional abnormalities
publisher	Radcliffe Medical Media
publishDate	2021
url	https://doaj.org/article/d1ddd6a0ce654bb089c1811bc45d807c
work_keys_str_mv	AT juntakahashi pathophysiologyanddiagnosisofcoronaryfunctionalabnormalities AT akirasuda pathophysiologyanddiagnosisofcoronaryfunctionalabnormalities AT kensukenishimiya pathophysiologyanddiagnosisofcoronaryfunctionalabnormalities AT shigeogodo pathophysiologyanddiagnosisofcoronaryfunctionalabnormalities AT satoshiyasuda pathophysiologyanddiagnosisofcoronaryfunctionalabnormalities AT hiroakishimokawa pathophysiologyanddiagnosisofcoronaryfunctionalabnormalities
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Pathophysiology and Diagnosis of Coronary Functional Abnormalities

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