Type and extent of somatic morbidity before and after the diagnosis of hypothyroidism. a nationwide register study.

<h4>Background</h4>Hypothyroidism has been linked with an increased risk of other morbidities, such as cardiovascular diseases and diabetes mellitus. However, the temporal relationship between these diseases and the diagnosis of hypothyroidism is not well illuminated. Such information ma...

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Autores principales:	Marianne Thvilum, Frans Brandt, Dorthe Almind, Kaare Christensen, Thomas Heiberg Brix, Laszlo Hegedüs
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d1e199d8cf8b4f2e966d2ed643e52757
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spelling	oai:doaj.org-article:d1e199d8cf8b4f2e966d2ed643e527572021-11-18T08:54:59ZType and extent of somatic morbidity before and after the diagnosis of hypothyroidism. a nationwide register study.1932-620310.1371/journal.pone.0075789https://doaj.org/article/d1e199d8cf8b4f2e966d2ed643e527572013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24066186/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Hypothyroidism has been linked with an increased risk of other morbidities, such as cardiovascular diseases and diabetes mellitus. However, the temporal relationship between these diseases and the diagnosis of hypothyroidism is not well illuminated. Such information may provide insight into causal relationships between hypothyroidism and other morbidities.<h4>Aim</h4>To investigate the type and extent of somatic morbidity before and after a diagnosis of hypothyroidism.<h4>Methods</h4>Observational cohort study. From official Danish health registers, 2822 hypothyroid singletons were identified and matched 1:4 with non-hypothyroid controls and observed over a mean period of 6 years. Frequency of different morbidities was obtained by person-to-person linking in the registers. Logistic and Cox regression models were used to assess the risk of morbidity before and after the diagnosis of hypothyroidism, respectively.<h4>Results</h4>Prior to the diagnosis of hypothyroidism there was a significantly increased risk of being diagnosed with cardiovascular diseases (odds ratio (OR) 1.37; 95% confidence interval (CI): 1.19-1.58), lung diseases (OR 1.25; 95% CI: 1.13-1.39), diabetes mellitus (OR 1.92; 95% CI: 1.61-2.29), as well as malignant diseases (OR 1.24; 95% CI: 1.06-1.45). Following the diagnosis of hypothyroidism there was a significantly increased risk of being diagnosed with cardiovascular diseases (hazard ratio (HR) 1.36; 95% CI: 1.15-1.60); lung diseases (HR 1.51; 95% CI: 1.30-1.75); and diabetes mellitus (HR 1.40; 95% CI: 1.11-1.77).<h4>Conclusions</h4>Prior to the diagnosis of hypothyroidism there is an excess risk of being diagnosed with cardiovascular diseases, lung diseases, diabetes mellitus, and malignant diseases. Following the diagnosis of hypothyroidism we demonstrate an increased frequency of cardiovascular diseases, lung diseases, and diabetes mellitus.Marianne ThvilumFrans BrandtDorthe AlmindKaare ChristensenThomas Heiberg BrixLaszlo HegedüsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e75789 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marianne Thvilum Frans Brandt Dorthe Almind Kaare Christensen Thomas Heiberg Brix Laszlo Hegedüs Type and extent of somatic morbidity before and after the diagnosis of hypothyroidism. a nationwide register study.
description	<h4>Background</h4>Hypothyroidism has been linked with an increased risk of other morbidities, such as cardiovascular diseases and diabetes mellitus. However, the temporal relationship between these diseases and the diagnosis of hypothyroidism is not well illuminated. Such information may provide insight into causal relationships between hypothyroidism and other morbidities.<h4>Aim</h4>To investigate the type and extent of somatic morbidity before and after a diagnosis of hypothyroidism.<h4>Methods</h4>Observational cohort study. From official Danish health registers, 2822 hypothyroid singletons were identified and matched 1:4 with non-hypothyroid controls and observed over a mean period of 6 years. Frequency of different morbidities was obtained by person-to-person linking in the registers. Logistic and Cox regression models were used to assess the risk of morbidity before and after the diagnosis of hypothyroidism, respectively.<h4>Results</h4>Prior to the diagnosis of hypothyroidism there was a significantly increased risk of being diagnosed with cardiovascular diseases (odds ratio (OR) 1.37; 95% confidence interval (CI): 1.19-1.58), lung diseases (OR 1.25; 95% CI: 1.13-1.39), diabetes mellitus (OR 1.92; 95% CI: 1.61-2.29), as well as malignant diseases (OR 1.24; 95% CI: 1.06-1.45). Following the diagnosis of hypothyroidism there was a significantly increased risk of being diagnosed with cardiovascular diseases (hazard ratio (HR) 1.36; 95% CI: 1.15-1.60); lung diseases (HR 1.51; 95% CI: 1.30-1.75); and diabetes mellitus (HR 1.40; 95% CI: 1.11-1.77).<h4>Conclusions</h4>Prior to the diagnosis of hypothyroidism there is an excess risk of being diagnosed with cardiovascular diseases, lung diseases, diabetes mellitus, and malignant diseases. Following the diagnosis of hypothyroidism we demonstrate an increased frequency of cardiovascular diseases, lung diseases, and diabetes mellitus.
format	article
author	Marianne Thvilum Frans Brandt Dorthe Almind Kaare Christensen Thomas Heiberg Brix Laszlo Hegedüs
author_facet	Marianne Thvilum Frans Brandt Dorthe Almind Kaare Christensen Thomas Heiberg Brix Laszlo Hegedüs
author_sort	Marianne Thvilum
title	Type and extent of somatic morbidity before and after the diagnosis of hypothyroidism. a nationwide register study.
title_short	Type and extent of somatic morbidity before and after the diagnosis of hypothyroidism. a nationwide register study.
title_full	Type and extent of somatic morbidity before and after the diagnosis of hypothyroidism. a nationwide register study.
title_fullStr	Type and extent of somatic morbidity before and after the diagnosis of hypothyroidism. a nationwide register study.
title_full_unstemmed	Type and extent of somatic morbidity before and after the diagnosis of hypothyroidism. a nationwide register study.
title_sort	type and extent of somatic morbidity before and after the diagnosis of hypothyroidism. a nationwide register study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d1e199d8cf8b4f2e966d2ed643e52757
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Type and extent of somatic morbidity before and after the diagnosis of hypothyroidism. a nationwide register study.

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