Current HLA Investigations on SARS-CoV-2 and Perspectives

The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has triggered numerous efforts in clinical and research settings to better understand the host genetics’ interactions and the severity of COVID-19. Due to the established major role played by MHC/HLA polymorphism in infecti...

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Autores principales:	Venceslas Douillard, Erick C. Castelli, Steven J. Mack, Jill A. Hollenbach, Pierre-Antoine Gourraud, Nicolas Vince, Sophie Limou, for the Covid-19\|HLA & Immunogenetics Consortium and the SNP-HLA Reference Consortium
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	MHC HLA association analysis SARS- CoV-2 COVID-19 immunogenetics Genetics QH426-470
Acceso en línea:	https://doaj.org/article/d1e27b2e91de46be91488cd5c11819eb
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spelling	oai:doaj.org-article:d1e27b2e91de46be91488cd5c11819eb2021-12-01T13:58:59ZCurrent HLA Investigations on SARS-CoV-2 and Perspectives1664-802110.3389/fgene.2021.774922https://doaj.org/article/d1e27b2e91de46be91488cd5c11819eb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.774922/fullhttps://doaj.org/toc/1664-8021The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has triggered numerous efforts in clinical and research settings to better understand the host genetics’ interactions and the severity of COVID-19. Due to the established major role played by MHC/HLA polymorphism in infectious disease course and susceptibility, immunologists and geneticists have teamed up to investigate its contribution to the SARS-CoV-2 infection and COVID-19 progression. A major goal of the Covid-19\|HLA & Immunogenetics Consortium is to support and unify these efforts. Here, we present a review of HLA immunogenomics studies in the SARS-CoV-2 pandemic and reflect on the role of various HLA data, their limitation and future perspectives.Venceslas DouillardErick C. CastelliSteven J. MackJill A. HollenbachPierre-Antoine GourraudNicolas VinceSophie LimouSophie Limoufor the Covid-19\|HLA & Immunogenetics Consortium and the SNP-HLA Reference ConsortiumFrontiers Media S.A.articleMHCHLAassociation analysisSARS- CoV-2COVID-19immunogeneticsGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MHC HLA association analysis SARS- CoV-2 COVID-19 immunogenetics Genetics QH426-470
spellingShingle	MHC HLA association analysis SARS- CoV-2 COVID-19 immunogenetics Genetics QH426-470 Venceslas Douillard Erick C. Castelli Steven J. Mack Jill A. Hollenbach Pierre-Antoine Gourraud Nicolas Vince Sophie Limou Sophie Limou for the Covid-19\|HLA & Immunogenetics Consortium and the SNP-HLA Reference Consortium Current HLA Investigations on SARS-CoV-2 and Perspectives
description	The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has triggered numerous efforts in clinical and research settings to better understand the host genetics’ interactions and the severity of COVID-19. Due to the established major role played by MHC/HLA polymorphism in infectious disease course and susceptibility, immunologists and geneticists have teamed up to investigate its contribution to the SARS-CoV-2 infection and COVID-19 progression. A major goal of the Covid-19\|HLA & Immunogenetics Consortium is to support and unify these efforts. Here, we present a review of HLA immunogenomics studies in the SARS-CoV-2 pandemic and reflect on the role of various HLA data, their limitation and future perspectives.
format	article
author	Venceslas Douillard Erick C. Castelli Steven J. Mack Jill A. Hollenbach Pierre-Antoine Gourraud Nicolas Vince Sophie Limou Sophie Limou for the Covid-19\|HLA & Immunogenetics Consortium and the SNP-HLA Reference Consortium
author_facet	Venceslas Douillard Erick C. Castelli Steven J. Mack Jill A. Hollenbach Pierre-Antoine Gourraud Nicolas Vince Sophie Limou Sophie Limou for the Covid-19\|HLA & Immunogenetics Consortium and the SNP-HLA Reference Consortium
author_sort	Venceslas Douillard
title	Current HLA Investigations on SARS-CoV-2 and Perspectives
title_short	Current HLA Investigations on SARS-CoV-2 and Perspectives
title_full	Current HLA Investigations on SARS-CoV-2 and Perspectives
title_fullStr	Current HLA Investigations on SARS-CoV-2 and Perspectives
title_full_unstemmed	Current HLA Investigations on SARS-CoV-2 and Perspectives
title_sort	current hla investigations on sars-cov-2 and perspectives
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d1e27b2e91de46be91488cd5c11819eb
work_keys_str_mv	AT venceslasdouillard currenthlainvestigationsonsarscov2andperspectives AT erickccastelli currenthlainvestigationsonsarscov2andperspectives AT stevenjmack currenthlainvestigationsonsarscov2andperspectives AT jillahollenbach currenthlainvestigationsonsarscov2andperspectives AT pierreantoinegourraud currenthlainvestigationsonsarscov2andperspectives AT nicolasvince currenthlainvestigationsonsarscov2andperspectives AT sophielimou currenthlainvestigationsonsarscov2andperspectives AT sophielimou currenthlainvestigationsonsarscov2andperspectives AT forthecovid19hlaimmunogeneticsconsortiumandthesnphlareferenceconsortium currenthlainvestigationsonsarscov2andperspectives
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Current HLA Investigations on SARS-CoV-2 and Perspectives

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