The structure–function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa

Abstract To investigate the structure–function correlation analysed by full-field electroretinography (ffERG) and optical coherence tomography (OCT) in typical and pericentral subtypes of retinitis pigmentosa (RP). A retrospective, cross-sectional, observational study of right eyes was conducted. Th...

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Autores principales:	Ching-Wen Huang, Jung-Je Yang, Chang-Hao Yang, Chung-May Yang, Fung-Rong Hu, Tzyy-Chang Ho, Ta-Ching Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d1e388a7d79347479e3be942f8143652
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spelling	oai:doaj.org-article:d1e388a7d79347479e3be942f81436522021-12-02T18:51:46ZThe structure–function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa10.1038/s41598-021-96570-72045-2322https://doaj.org/article/d1e388a7d79347479e3be942f81436522021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96570-7https://doaj.org/toc/2045-2322Abstract To investigate the structure–function correlation analysed by full-field electroretinography (ffERG) and optical coherence tomography (OCT) in typical and pericentral subtypes of retinitis pigmentosa (RP). A retrospective, cross-sectional, observational study of right eyes was conducted. The primary analysis used ffERG data to compare the RP subtypes. The subgroup analysis was used to correlate the structure, analysed by OCT, and function, determined by ffERG. Linear regressions explored the relationship between best-corrected visual acuity (BCVA) and multiple parameters. A total of 188 eyes were included. Amplitudes of responses of rod, rod-cone, cone, and 30 Hz flicker of typical type were lower than those of pericentral and other types. In the subgroup analysis, 41 and 21 eyes of the typical and pericentral types were studied, respectively. The correlation between the estimated preserved photoreceptor area and all ffERG amplitude parameters were significant in the typical type, but not in pericentral type. Old age, decreased intact ellipsoid zone length, typical type, and thin central retinal thickness were negatively correlated with BCVA. Typical type RP developed more extensive degeneration and poorer BCVA compared to others. Strong structure–function correlation was found in typical type while not in pericentral type. OCT may be a useful tool for monitoring RP status in typical type, providing useful parameters for the prediction of BCVA.Ching-Wen HuangJung-Je YangChang-Hao YangChung-May YangFung-Rong HuTzyy-Chang HoTa-Ching ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ching-Wen Huang Jung-Je Yang Chang-Hao Yang Chung-May Yang Fung-Rong Hu Tzyy-Chang Ho Ta-Ching Chen The structure–function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa
description	Abstract To investigate the structure–function correlation analysed by full-field electroretinography (ffERG) and optical coherence tomography (OCT) in typical and pericentral subtypes of retinitis pigmentosa (RP). A retrospective, cross-sectional, observational study of right eyes was conducted. The primary analysis used ffERG data to compare the RP subtypes. The subgroup analysis was used to correlate the structure, analysed by OCT, and function, determined by ffERG. Linear regressions explored the relationship between best-corrected visual acuity (BCVA) and multiple parameters. A total of 188 eyes were included. Amplitudes of responses of rod, rod-cone, cone, and 30 Hz flicker of typical type were lower than those of pericentral and other types. In the subgroup analysis, 41 and 21 eyes of the typical and pericentral types were studied, respectively. The correlation between the estimated preserved photoreceptor area and all ffERG amplitude parameters were significant in the typical type, but not in pericentral type. Old age, decreased intact ellipsoid zone length, typical type, and thin central retinal thickness were negatively correlated with BCVA. Typical type RP developed more extensive degeneration and poorer BCVA compared to others. Strong structure–function correlation was found in typical type while not in pericentral type. OCT may be a useful tool for monitoring RP status in typical type, providing useful parameters for the prediction of BCVA.
format	article
author	Ching-Wen Huang Jung-Je Yang Chang-Hao Yang Chung-May Yang Fung-Rong Hu Tzyy-Chang Ho Ta-Ching Chen
author_facet	Ching-Wen Huang Jung-Je Yang Chang-Hao Yang Chung-May Yang Fung-Rong Hu Tzyy-Chang Ho Ta-Ching Chen
author_sort	Ching-Wen Huang
title	The structure–function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa
title_short	The structure–function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa
title_full	The structure–function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa
title_fullStr	The structure–function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa
title_full_unstemmed	The structure–function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa
title_sort	structure–function correlation analysed by oct and full field erg in typical and pericentral subtypes of retinitis pigmentosa
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d1e388a7d79347479e3be942f8143652
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The structure–function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa

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