In vitro determination of drug transfer from drug-coated balloons.

Drug-coated balloons are medical devices designed to locally deliver drug to diseased segments of the vessel wall. For these dosage forms, drug transfer to the vessel wall needs to be examined in detail, since drug released into the blood is cleared from the site. In order to examine drug transfer,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anne Seidlitz, Nadine Kotzan, Stefan Nagel, Thomas Reske, Niels Grabow, Claus Harder, Svea Petersen, Katrin Sternberg, Werner Weitschies
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d1e4b1006ff54d6fa7b457549ceb7d2f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d1e4b1006ff54d6fa7b457549ceb7d2f
record_format	dspace
spelling	oai:doaj.org-article:d1e4b1006ff54d6fa7b457549ceb7d2f2021-11-18T08:39:28ZIn vitro determination of drug transfer from drug-coated balloons.1932-620310.1371/journal.pone.0083992https://doaj.org/article/d1e4b1006ff54d6fa7b457549ceb7d2f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24391863/?tool=EBIhttps://doaj.org/toc/1932-6203Drug-coated balloons are medical devices designed to locally deliver drug to diseased segments of the vessel wall. For these dosage forms, drug transfer to the vessel wall needs to be examined in detail, since drug released into the blood is cleared from the site. In order to examine drug transfer, a new in vitro setup was developed combining the estimation of drug loss during advancement to the site of application in a model coronary artery pathway with a hydrogel compartment representing, as a very simplified model, the vessel wall. The transfer of fluorescent model substances as well as the drug paclitaxel from coated balloons to the simulated vessel wall was evaluated using this method. The model was suitable to quantify the fractions transferred to the hydrogel and also to qualitatively assess distribution patterns in the hydrogel film. In the case of fluorescein sodium, rhodamin b and paclitaxel, vast amounts of the coated substance were lost during the simulated passage and only very small fractions of about 1% of the total load were transferred to the gel. This must be attributed to good water solubility of the fluorescent substances and the mechanical instability of the paclitaxel coating. Transfer of the hydrophobic model substance triamterene was however nearly unaffected by the preliminary tracking procedure with transferred fractions ranging from 8% to 14%. Analysis of model substance distribution yielded inhomogeneous distributions indicating that the coating was not evenly distributed on the balloon surface and that a great fraction of the coating liquid did not penetrate the folds of the balloon. This finding is contradictory to the generally accepted assumption of a drug depot inside the folds and emphasizes the necessity to thoroughly characterize in vitro performance of drug-coated balloons to support the very promising clinical data.Anne SeidlitzNadine KotzanStefan NagelThomas ReskeNiels GrabowClaus HarderSvea PetersenKatrin SternbergWerner WeitschiesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83992 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anne Seidlitz Nadine Kotzan Stefan Nagel Thomas Reske Niels Grabow Claus Harder Svea Petersen Katrin Sternberg Werner Weitschies In vitro determination of drug transfer from drug-coated balloons.
description	Drug-coated balloons are medical devices designed to locally deliver drug to diseased segments of the vessel wall. For these dosage forms, drug transfer to the vessel wall needs to be examined in detail, since drug released into the blood is cleared from the site. In order to examine drug transfer, a new in vitro setup was developed combining the estimation of drug loss during advancement to the site of application in a model coronary artery pathway with a hydrogel compartment representing, as a very simplified model, the vessel wall. The transfer of fluorescent model substances as well as the drug paclitaxel from coated balloons to the simulated vessel wall was evaluated using this method. The model was suitable to quantify the fractions transferred to the hydrogel and also to qualitatively assess distribution patterns in the hydrogel film. In the case of fluorescein sodium, rhodamin b and paclitaxel, vast amounts of the coated substance were lost during the simulated passage and only very small fractions of about 1% of the total load were transferred to the gel. This must be attributed to good water solubility of the fluorescent substances and the mechanical instability of the paclitaxel coating. Transfer of the hydrophobic model substance triamterene was however nearly unaffected by the preliminary tracking procedure with transferred fractions ranging from 8% to 14%. Analysis of model substance distribution yielded inhomogeneous distributions indicating that the coating was not evenly distributed on the balloon surface and that a great fraction of the coating liquid did not penetrate the folds of the balloon. This finding is contradictory to the generally accepted assumption of a drug depot inside the folds and emphasizes the necessity to thoroughly characterize in vitro performance of drug-coated balloons to support the very promising clinical data.
format	article
author	Anne Seidlitz Nadine Kotzan Stefan Nagel Thomas Reske Niels Grabow Claus Harder Svea Petersen Katrin Sternberg Werner Weitschies
author_facet	Anne Seidlitz Nadine Kotzan Stefan Nagel Thomas Reske Niels Grabow Claus Harder Svea Petersen Katrin Sternberg Werner Weitschies
author_sort	Anne Seidlitz
title	In vitro determination of drug transfer from drug-coated balloons.
title_short	In vitro determination of drug transfer from drug-coated balloons.
title_full	In vitro determination of drug transfer from drug-coated balloons.
title_fullStr	In vitro determination of drug transfer from drug-coated balloons.
title_full_unstemmed	In vitro determination of drug transfer from drug-coated balloons.
title_sort	in vitro determination of drug transfer from drug-coated balloons.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d1e4b1006ff54d6fa7b457549ceb7d2f
work_keys_str_mv	AT anneseidlitz invitrodeterminationofdrugtransferfromdrugcoatedballoons AT nadinekotzan invitrodeterminationofdrugtransferfromdrugcoatedballoons AT stefannagel invitrodeterminationofdrugtransferfromdrugcoatedballoons AT thomasreske invitrodeterminationofdrugtransferfromdrugcoatedballoons AT nielsgrabow invitrodeterminationofdrugtransferfromdrugcoatedballoons AT clausharder invitrodeterminationofdrugtransferfromdrugcoatedballoons AT sveapetersen invitrodeterminationofdrugtransferfromdrugcoatedballoons AT katrinsternberg invitrodeterminationofdrugtransferfromdrugcoatedballoons AT wernerweitschies invitrodeterminationofdrugtransferfromdrugcoatedballoons
_version_	1718421528788336640

In vitro determination of drug transfer from drug-coated balloons.

Ejemplares similares