Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

Charcot-Marie-Tooth (CMT) is an inherited peripheral neuropathy. Here, the authors show that Rab35 forms a complex with genes implicated in CMT, MTMR13 and MTMR2, which regulates myelin growth by controlling mTORC1 signaling through lipid turnover.

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Autores principales:	Linda Sawade, Federica Grandi, Marianna Mignanelli, Genaro Patiño-López, Kerstin Klinkert, Francina Langa-Vives, Roberta Di Guardo, Arnaud Echard, Alessandra Bolino, Volker Haucke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d1e62855b2dc4aa889b4c3bfd2e4dbff
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spelling	oai:doaj.org-article:d1e62855b2dc4aa889b4c3bfd2e4dbff2021-12-02T15:02:30ZRab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth10.1038/s41467-020-16696-62041-1723https://doaj.org/article/d1e62855b2dc4aa889b4c3bfd2e4dbff2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16696-6https://doaj.org/toc/2041-1723Charcot-Marie-Tooth (CMT) is an inherited peripheral neuropathy. Here, the authors show that Rab35 forms a complex with genes implicated in CMT, MTMR13 and MTMR2, which regulates myelin growth by controlling mTORC1 signaling through lipid turnover.Linda SawadeFederica GrandiMarianna MignanelliGenaro Patiño-LópezKerstin KlinkertFrancina Langa-VivesRoberta Di GuardoArnaud EchardAlessandra BolinoVolker HauckeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Linda Sawade Federica Grandi Marianna Mignanelli Genaro Patiño-López Kerstin Klinkert Francina Langa-Vives Roberta Di Guardo Arnaud Echard Alessandra Bolino Volker Haucke Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth
description	Charcot-Marie-Tooth (CMT) is an inherited peripheral neuropathy. Here, the authors show that Rab35 forms a complex with genes implicated in CMT, MTMR13 and MTMR2, which regulates myelin growth by controlling mTORC1 signaling through lipid turnover.
format	article
author	Linda Sawade Federica Grandi Marianna Mignanelli Genaro Patiño-López Kerstin Klinkert Francina Langa-Vives Roberta Di Guardo Arnaud Echard Alessandra Bolino Volker Haucke
author_facet	Linda Sawade Federica Grandi Marianna Mignanelli Genaro Patiño-López Kerstin Klinkert Francina Langa-Vives Roberta Di Guardo Arnaud Echard Alessandra Bolino Volker Haucke
author_sort	Linda Sawade
title	Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth
title_short	Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth
title_full	Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth
title_fullStr	Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth
title_full_unstemmed	Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth
title_sort	rab35-regulated lipid turnover by myotubularins represses mtorc1 activity and controls myelin growth
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d1e62855b2dc4aa889b4c3bfd2e4dbff
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Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

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