Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

Charcot-Marie-Tooth (CMT) is an inherited peripheral neuropathy. Here, the authors show that Rab35 forms a complex with genes implicated in CMT, MTMR13 and MTMR2, which regulates myelin growth by controlling mTORC1 signaling through lipid turnover.

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Detalles Bibliográficos
Autores principales: Linda Sawade, Federica Grandi, Marianna Mignanelli, Genaro Patiño-López, Kerstin Klinkert, Francina Langa-Vives, Roberta Di Guardo, Arnaud Echard, Alessandra Bolino, Volker Haucke
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/d1e62855b2dc4aa889b4c3bfd2e4dbff
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