Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin

Perforin is part of the cytotoxic effector mechanism of CD8+ T cells. Here the authors show that antigen-induced perforin release from CD8 T cells into antigen-presenting cells can activate NLRP3 inflammasome to constitute a positive feedback loop to promote anti-tumour immunity and allo-responses.

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Autores principales:	Yikun Yao, Siyuan Chen, Mengtao Cao, Xing Fan, Tao Yang, Yin Huang, Xinyang Song, Yongqin Li, Lilin Ye, Nan Shen, Yufang Shi, Xiaoxia Li, Feng Wang, Youcun Qian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d1e62bdfffbc49eca8c485e2ff13f254
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spelling	oai:doaj.org-article:d1e62bdfffbc49eca8c485e2ff13f2542021-12-02T14:40:35ZAntigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin10.1038/ncomms154022041-1723https://doaj.org/article/d1e62bdfffbc49eca8c485e2ff13f2542017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15402https://doaj.org/toc/2041-1723Perforin is part of the cytotoxic effector mechanism of CD8+ T cells. Here the authors show that antigen-induced perforin release from CD8 T cells into antigen-presenting cells can activate NLRP3 inflammasome to constitute a positive feedback loop to promote anti-tumour immunity and allo-responses.Yikun YaoSiyuan ChenMengtao CaoXing FanTao YangYin HuangXinyang SongYongqin LiLilin YeNan ShenYufang ShiXiaoxia LiFeng WangYoucun QianNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yikun Yao Siyuan Chen Mengtao Cao Xing Fan Tao Yang Yin Huang Xinyang Song Yongqin Li Lilin Ye Nan Shen Yufang Shi Xiaoxia Li Feng Wang Youcun Qian Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin
description	Perforin is part of the cytotoxic effector mechanism of CD8+ T cells. Here the authors show that antigen-induced perforin release from CD8 T cells into antigen-presenting cells can activate NLRP3 inflammasome to constitute a positive feedback loop to promote anti-tumour immunity and allo-responses.
format	article
author	Yikun Yao Siyuan Chen Mengtao Cao Xing Fan Tao Yang Yin Huang Xinyang Song Yongqin Li Lilin Ye Nan Shen Yufang Shi Xiaoxia Li Feng Wang Youcun Qian
author_facet	Yikun Yao Siyuan Chen Mengtao Cao Xing Fan Tao Yang Yin Huang Xinyang Song Yongqin Li Lilin Ye Nan Shen Yufang Shi Xiaoxia Li Feng Wang Youcun Qian
author_sort	Yikun Yao
title	Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin
title_short	Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin
title_full	Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin
title_fullStr	Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin
title_full_unstemmed	Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin
title_sort	antigen-specific cd8+ t cell feedback activates nlrp3 inflammasome in antigen-presenting cells through perforin
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d1e62bdfffbc49eca8c485e2ff13f254
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Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin

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