TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs
T-cell receptors (TCRs) encode clinically valuable information that reflects prior antigen exposure and potential future response. However, despite advances in deep repertoire sequencing, enormous TCR diversity complicates the use of TCR clonotypes as clinical biomarkers. We propose a new framework...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
eLife Sciences Publications Ltd
2021
|
| Subjects: | |
| Online Access: | https://doaj.org/article/d1ecb3c26e0145ee974f654e715a1b6d |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Be the first to leave a comment!