Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis

The activation of hepatic stellate cells (HSC) plays a key role in the progression of hepatic fibrosis, it is essential to remove activated HSC through apoptosis to reverse hepatic fibrosis. Schisandrin B (Sch B) is the main chemical component of schisandrin lignan, and it has been reported to have...

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Autores principales:	Zhiman Li, Lijuan Zhao, Yunshi Xia, Jianbo Chen, Mei Hua, Yinshi Sun
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	schisandrin B hepatic stellate cell apoptosis TGF-β1 Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/d1f062135bf941729ef56c0d3f63615d
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spelling	oai:doaj.org-article:d1f062135bf941729ef56c0d3f63615d2021-11-25T18:28:05ZSchisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis10.3390/molecules262268821420-3049https://doaj.org/article/d1f062135bf941729ef56c0d3f63615d2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6882https://doaj.org/toc/1420-3049The activation of hepatic stellate cells (HSC) plays a key role in the progression of hepatic fibrosis, it is essential to remove activated HSC through apoptosis to reverse hepatic fibrosis. Schisandrin B (Sch B) is the main chemical component of schisandrin lignan, and it has been reported to have good hepatoprotective effects. However, Schisandrin B on HSC apoptosis remains unclear. In our study, we stimulated the HSC-T6 and LX-2 cell lines with TGF-β1 to induce cell activation, and the proliferation and apoptosis of the activated HSC-T6 and LX-2 cells were detected after treatment with different doses of Schisandrin B. Flow cytometry results showed that Sch B significantly reduced the activity of activated HSC-T6 and LX-2 cells and significantly induced apoptosis. In addition, the cleaved-Caspase-3 levels were increased, the Bax activity was increased, and the Bcl-2 expression was decreased in HSC-T6 and LX-2 cells treated with Sch B. Our study showed that Sch B inhibited the TGF-β1-induced activity of hepatic stellate cells by promoting apoptosis.Zhiman LiLijuan ZhaoYunshi XiaJianbo ChenMei HuaYinshi SunMDPI AGarticleschisandrin Bhepatic stellate cellapoptosisTGF-β1Organic chemistryQD241-441ENMolecules, Vol 26, Iss 6882, p 6882 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	schisandrin B hepatic stellate cell apoptosis TGF-β1 Organic chemistry QD241-441
spellingShingle	schisandrin B hepatic stellate cell apoptosis TGF-β1 Organic chemistry QD241-441 Zhiman Li Lijuan Zhao Yunshi Xia Jianbo Chen Mei Hua Yinshi Sun Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis
description	The activation of hepatic stellate cells (HSC) plays a key role in the progression of hepatic fibrosis, it is essential to remove activated HSC through apoptosis to reverse hepatic fibrosis. Schisandrin B (Sch B) is the main chemical component of schisandrin lignan, and it has been reported to have good hepatoprotective effects. However, Schisandrin B on HSC apoptosis remains unclear. In our study, we stimulated the HSC-T6 and LX-2 cell lines with TGF-β1 to induce cell activation, and the proliferation and apoptosis of the activated HSC-T6 and LX-2 cells were detected after treatment with different doses of Schisandrin B. Flow cytometry results showed that Sch B significantly reduced the activity of activated HSC-T6 and LX-2 cells and significantly induced apoptosis. In addition, the cleaved-Caspase-3 levels were increased, the Bax activity was increased, and the Bcl-2 expression was decreased in HSC-T6 and LX-2 cells treated with Sch B. Our study showed that Sch B inhibited the TGF-β1-induced activity of hepatic stellate cells by promoting apoptosis.
format	article
author	Zhiman Li Lijuan Zhao Yunshi Xia Jianbo Chen Mei Hua Yinshi Sun
author_facet	Zhiman Li Lijuan Zhao Yunshi Xia Jianbo Chen Mei Hua Yinshi Sun
author_sort	Zhiman Li
title	Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis
title_short	Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis
title_full	Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis
title_fullStr	Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis
title_full_unstemmed	Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis
title_sort	schisandrin b attenuates hepatic stellate cell activation and promotes apoptosis to protect against liver fibrosis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d1f062135bf941729ef56c0d3f63615d
work_keys_str_mv	AT zhimanli schisandrinbattenuateshepaticstellatecellactivationandpromotesapoptosistoprotectagainstliverfibrosis AT lijuanzhao schisandrinbattenuateshepaticstellatecellactivationandpromotesapoptosistoprotectagainstliverfibrosis AT yunshixia schisandrinbattenuateshepaticstellatecellactivationandpromotesapoptosistoprotectagainstliverfibrosis AT jianbochen schisandrinbattenuateshepaticstellatecellactivationandpromotesapoptosistoprotectagainstliverfibrosis AT meihua schisandrinbattenuateshepaticstellatecellactivationandpromotesapoptosistoprotectagainstliverfibrosis AT yinshisun schisandrinbattenuateshepaticstellatecellactivationandpromotesapoptosistoprotectagainstliverfibrosis
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Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis

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