SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response

The ongoing COVID-19 pandemic is caused by SARS-CoV-2, which is rapidly evolving with better transmissibility. Understanding the molecular basis of the SARS-CoV-2 interaction with host cells is of paramount significance, and development of antiviral agents provides new avenues to prevent and treat...

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Autores principales:	Yongzhen Liu, Chao Qin, Youliang Rao, Chau Ngo, Joshua J. Feng, Jun Zhao, Shu Zhang, Ting-Yu Wang, Jessica Carriere, Ali Can Savas, Mehrnaz Zarinfar, Stephanie Rice, Hanging Yang, Weiming Yuan, Julio A. Camarero, Jianhua Yu, Xiaojiang S. Chen, Chao Zhang, Pinghui Feng
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/d1f591fa063b42b0b3faac6bdd373a47
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spelling	oai:doaj.org-article:d1f591fa063b42b0b3faac6bdd373a472021-11-03T21:52:35ZSARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response2150-751110.1128/mBio.02335-21https://doaj.org/article/d1f591fa063b42b0b3faac6bdd373a472021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02335-21https://doaj.org/toc/2150-7511 The ongoing COVID-19 pandemic is caused by SARS-CoV-2, which is rapidly evolving with better transmissibility. Understanding the molecular basis of the SARS-CoV-2 interaction with host cells is of paramount significance, and development of antiviral agents provides new avenues to prevent and treat COVID-19 diseases. This study describes a molecular characterization of innate immune evasion mediated by the SARS-CoV-2 Nsp5 main protease and subsequent development of a small-molecule inhibitor.Yongzhen LiuChao QinYouliang RaoChau NgoJoshua J. FengJun ZhaoShu ZhangTing-Yu WangJessica CarriereAli Can SavasMehrnaz ZarinfarStephanie RiceHanging YangWeiming YuanJulio A. CamareroJianhua YuXiaojiang S. ChenChao ZhangPinghui FengAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Yongzhen Liu Chao Qin Youliang Rao Chau Ngo Joshua J. Feng Jun Zhao Shu Zhang Ting-Yu Wang Jessica Carriere Ali Can Savas Mehrnaz Zarinfar Stephanie Rice Hanging Yang Weiming Yuan Julio A. Camarero Jianhua Yu Xiaojiang S. Chen Chao Zhang Pinghui Feng SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response
description	The ongoing COVID-19 pandemic is caused by SARS-CoV-2, which is rapidly evolving with better transmissibility. Understanding the molecular basis of the SARS-CoV-2 interaction with host cells is of paramount significance, and development of antiviral agents provides new avenues to prevent and treat COVID-19 diseases. This study describes a molecular characterization of innate immune evasion mediated by the SARS-CoV-2 Nsp5 main protease and subsequent development of a small-molecule inhibitor.
format	article
author	Yongzhen Liu Chao Qin Youliang Rao Chau Ngo Joshua J. Feng Jun Zhao Shu Zhang Ting-Yu Wang Jessica Carriere Ali Can Savas Mehrnaz Zarinfar Stephanie Rice Hanging Yang Weiming Yuan Julio A. Camarero Jianhua Yu Xiaojiang S. Chen Chao Zhang Pinghui Feng
author_facet	Yongzhen Liu Chao Qin Youliang Rao Chau Ngo Joshua J. Feng Jun Zhao Shu Zhang Ting-Yu Wang Jessica Carriere Ali Can Savas Mehrnaz Zarinfar Stephanie Rice Hanging Yang Weiming Yuan Julio A. Camarero Jianhua Yu Xiaojiang S. Chen Chao Zhang Pinghui Feng
author_sort	Yongzhen Liu
title	SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response
title_short	SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response
title_full	SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response
title_fullStr	SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response
title_full_unstemmed	SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response
title_sort	sars-cov-2 nsp5 demonstrates two distinct mechanisms targeting rig-i and mavs to evade the innate immune response
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/d1f591fa063b42b0b3faac6bdd373a47
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SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response

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