Ocular hypotensive effects of prostaglandin analogs in Japanese patients with normal-tension glaucoma: a literature review

Yasutaka Takagi,1 Kazunori Santo,1 Masayo Hashimoto,1 Takeo Fukuchi2 1Japan Medical Affairs Group, Santen Pharmaceutical Co., Ltd., Osaka, Japan; 2Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan Purpose: This paper ai...

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Autores principales:	Takagi Y, Santo K, Hashimoto M, Fukuchi T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Japanese normal-tension glaucoma ocular hypotensive effects prostaglandin analogues Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/d1f6f1aaa2674e66b34f7b37cb65e744
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spelling	oai:doaj.org-article:d1f6f1aaa2674e66b34f7b37cb65e7442021-12-02T09:29:19ZOcular hypotensive effects of prostaglandin analogs in Japanese patients with normal-tension glaucoma: a literature review1177-5483https://doaj.org/article/d1f6f1aaa2674e66b34f7b37cb65e7442018-09-01T00:00:00Zhttps://www.dovepress.com/ocular-hypotensive-effects-of-prostaglandin-analogs-in-japanese-patien-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Yasutaka Takagi,1 Kazunori Santo,1 Masayo Hashimoto,1 Takeo Fukuchi2 1Japan Medical Affairs Group, Santen Pharmaceutical Co., Ltd., Osaka, Japan; 2Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan Purpose: This paper aimed to evaluate the intraocular pressure (IOP)-lowering effects of prostaglandin analogs (PGAs) in Japanese patients with normal-tension glaucoma (NTG) by reviewing the current literature. Methods: In February 2018, database searches were performed in PubMed, Embase, ProQuest, and the Japanese databases JAPICDOC and JMEDPlus. Studies were sorted into two categories: Category 1 consisted of studies of patients with NTG who reported reduced IOP values and Category 2 consisted of studies of patients with NTG who had IOP values at predosing and a final evaluation point. Search terms included ([unoprostone or latanoprost or travoprost or bimatoprost or tafluprost] and [glaucoma] and [Japan or Japanese]). The weighted ocular hypotensive efficacy was calculated. A scatter plot analysis was performed and a regression equation was calculated for each medication. The fitting of each regression equation was evaluated by the least squares method. Results: Eleven articles were eligible for Category 1 and 25 articles for Category 2. In the rank order of IOP-lowering efficacy of PGAs, bimatoprost was the strongest and latanoprost the weakest. Travoprost and tafluprost had almost the same level of ocular hypotensive effect, and both were stronger than latanoprost. The scatter plot analysis showed that all PGAs reduced IOP by 15%–20%. At higher IOP (17–18 mmHg), the ocular hypotensive effect was almost the same with latanoprost, travoprost, and tafluprost. In contrast, at lower IOP (12–15 mmHg), the IOP reduction with latanoprost was weaker than with travoprost or tafluprost. Conclusion: This literature review of the ocular hypotensive effects of PGAs in Japanese patients with NTG highlighted that PGAs had different ocular hypotensive effects. Ophthalmologists should understand the IOP-lowering profiles of various PGAs and apply them to patients with NTG on a case-by-case basis. Trial registration: UMIN Clinical Trials Registry UMIN000032344. Keywords: Japanese, normal-tension glaucoma, ocular hypotensive effects, prostaglandin analogsTakagi YSanto KHashimoto MFukuchi TDove Medical PressarticleJapanesenormal-tension glaucomaocular hypotensive effectsprostaglandin analoguesOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1837-1844 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Japanese normal-tension glaucoma ocular hypotensive effects prostaglandin analogues Ophthalmology RE1-994
spellingShingle	Japanese normal-tension glaucoma ocular hypotensive effects prostaglandin analogues Ophthalmology RE1-994 Takagi Y Santo K Hashimoto M Fukuchi T Ocular hypotensive effects of prostaglandin analogs in Japanese patients with normal-tension glaucoma: a literature review
description	Yasutaka Takagi,1 Kazunori Santo,1 Masayo Hashimoto,1 Takeo Fukuchi2 1Japan Medical Affairs Group, Santen Pharmaceutical Co., Ltd., Osaka, Japan; 2Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan Purpose: This paper aimed to evaluate the intraocular pressure (IOP)-lowering effects of prostaglandin analogs (PGAs) in Japanese patients with normal-tension glaucoma (NTG) by reviewing the current literature. Methods: In February 2018, database searches were performed in PubMed, Embase, ProQuest, and the Japanese databases JAPICDOC and JMEDPlus. Studies were sorted into two categories: Category 1 consisted of studies of patients with NTG who reported reduced IOP values and Category 2 consisted of studies of patients with NTG who had IOP values at predosing and a final evaluation point. Search terms included ([unoprostone or latanoprost or travoprost or bimatoprost or tafluprost] and [glaucoma] and [Japan or Japanese]). The weighted ocular hypotensive efficacy was calculated. A scatter plot analysis was performed and a regression equation was calculated for each medication. The fitting of each regression equation was evaluated by the least squares method. Results: Eleven articles were eligible for Category 1 and 25 articles for Category 2. In the rank order of IOP-lowering efficacy of PGAs, bimatoprost was the strongest and latanoprost the weakest. Travoprost and tafluprost had almost the same level of ocular hypotensive effect, and both were stronger than latanoprost. The scatter plot analysis showed that all PGAs reduced IOP by 15%–20%. At higher IOP (17–18 mmHg), the ocular hypotensive effect was almost the same with latanoprost, travoprost, and tafluprost. In contrast, at lower IOP (12–15 mmHg), the IOP reduction with latanoprost was weaker than with travoprost or tafluprost. Conclusion: This literature review of the ocular hypotensive effects of PGAs in Japanese patients with NTG highlighted that PGAs had different ocular hypotensive effects. Ophthalmologists should understand the IOP-lowering profiles of various PGAs and apply them to patients with NTG on a case-by-case basis. Trial registration: UMIN Clinical Trials Registry UMIN000032344. Keywords: Japanese, normal-tension glaucoma, ocular hypotensive effects, prostaglandin analogs
format	article
author	Takagi Y Santo K Hashimoto M Fukuchi T
author_facet	Takagi Y Santo K Hashimoto M Fukuchi T
author_sort	Takagi Y
title	Ocular hypotensive effects of prostaglandin analogs in Japanese patients with normal-tension glaucoma: a literature review
title_short	Ocular hypotensive effects of prostaglandin analogs in Japanese patients with normal-tension glaucoma: a literature review
title_full	Ocular hypotensive effects of prostaglandin analogs in Japanese patients with normal-tension glaucoma: a literature review
title_fullStr	Ocular hypotensive effects of prostaglandin analogs in Japanese patients with normal-tension glaucoma: a literature review
title_full_unstemmed	Ocular hypotensive effects of prostaglandin analogs in Japanese patients with normal-tension glaucoma: a literature review
title_sort	ocular hypotensive effects of prostaglandin analogs in japanese patients with normal-tension glaucoma: a literature review
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/d1f6f1aaa2674e66b34f7b37cb65e744
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Ocular hypotensive effects of prostaglandin analogs in Japanese patients with normal-tension glaucoma: a literature review

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