Testosterone is an endogenous regulator of BAFF and splenic B cell number
Testosterone deficiency is associated with autoimmunity and increased B cell numbers, but the underlying mechanism is unclear. Here the authors show that testosterone may modulate the production of B cell survival factor BAFF by fibroblastic reticular cells via regulation of splenic neurotransmitter...
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Nature Portfolio
2018
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oai:doaj.org-article:d1f804563c204b959332c0cb6ac7f78d2021-12-02T14:39:24ZTestosterone is an endogenous regulator of BAFF and splenic B cell number10.1038/s41467-018-04408-02041-1723https://doaj.org/article/d1f804563c204b959332c0cb6ac7f78d2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04408-0https://doaj.org/toc/2041-1723Testosterone deficiency is associated with autoimmunity and increased B cell numbers, but the underlying mechanism is unclear. Here the authors show that testosterone may modulate the production of B cell survival factor BAFF by fibroblastic reticular cells via regulation of splenic neurotransmitter levels.Anna S. WilhelmsonMarta Lantero RodriguezAlexandra StubeliusPer FogelstrandInger JohanssonMatthew B. BuechlerSteve LianoglouVarun N. KapoorMaria E. JohanssonJohan B. FagmanAmanda DuhlinPrabhanshu TripathiAlessandro CamponeschiBo T. PorseAntonius G. RolinkHans NissbrandtShannon J. TurleyHans CarlstenInga-Lill MårtenssonMikael C. I. KarlssonÅsa TivestenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Anna S. Wilhelmson Marta Lantero Rodriguez Alexandra Stubelius Per Fogelstrand Inger Johansson Matthew B. Buechler Steve Lianoglou Varun N. Kapoor Maria E. Johansson Johan B. Fagman Amanda Duhlin Prabhanshu Tripathi Alessandro Camponeschi Bo T. Porse Antonius G. Rolink Hans Nissbrandt Shannon J. Turley Hans Carlsten Inga-Lill Mårtensson Mikael C. I. Karlsson Åsa Tivesten Testosterone is an endogenous regulator of BAFF and splenic B cell number |
| description |
Testosterone deficiency is associated with autoimmunity and increased B cell numbers, but the underlying mechanism is unclear. Here the authors show that testosterone may modulate the production of B cell survival factor BAFF by fibroblastic reticular cells via regulation of splenic neurotransmitter levels. |
| format |
article |
| author |
Anna S. Wilhelmson Marta Lantero Rodriguez Alexandra Stubelius Per Fogelstrand Inger Johansson Matthew B. Buechler Steve Lianoglou Varun N. Kapoor Maria E. Johansson Johan B. Fagman Amanda Duhlin Prabhanshu Tripathi Alessandro Camponeschi Bo T. Porse Antonius G. Rolink Hans Nissbrandt Shannon J. Turley Hans Carlsten Inga-Lill Mårtensson Mikael C. I. Karlsson Åsa Tivesten |
| author_facet |
Anna S. Wilhelmson Marta Lantero Rodriguez Alexandra Stubelius Per Fogelstrand Inger Johansson Matthew B. Buechler Steve Lianoglou Varun N. Kapoor Maria E. Johansson Johan B. Fagman Amanda Duhlin Prabhanshu Tripathi Alessandro Camponeschi Bo T. Porse Antonius G. Rolink Hans Nissbrandt Shannon J. Turley Hans Carlsten Inga-Lill Mårtensson Mikael C. I. Karlsson Åsa Tivesten |
| author_sort |
Anna S. Wilhelmson |
| title |
Testosterone is an endogenous regulator of BAFF and splenic B cell number |
| title_short |
Testosterone is an endogenous regulator of BAFF and splenic B cell number |
| title_full |
Testosterone is an endogenous regulator of BAFF and splenic B cell number |
| title_fullStr |
Testosterone is an endogenous regulator of BAFF and splenic B cell number |
| title_full_unstemmed |
Testosterone is an endogenous regulator of BAFF and splenic B cell number |
| title_sort |
testosterone is an endogenous regulator of baff and splenic b cell number |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/d1f804563c204b959332c0cb6ac7f78d |
| work_keys_str_mv |
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| _version_ |
1718390620078211072 |