Status of corneal endothelial cells in the presence of silicone oil in the anterior chamber

Abstract To evaluate corneal endothelium damage with silicone oil (SO) presence in the anterior chamber after pars plana vitrectomy. We investigated the medical records of consecutive 54 eyes of 53 patients undergoing SO removal after pars plana vitrectomy with SO tamponade at Saitama Medical Center...

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Autores principales:	Machiko Shimmura-Tomita, Hiroko Takano, Yoshiaki Tanaka, Rina Takagi, Toshikatsu Kaburaki, Akihiro Kakehashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d204df69a6d1454d832ffea47d3410bc
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spelling	oai:doaj.org-article:d204df69a6d1454d832ffea47d3410bc2021-12-02T15:39:41ZStatus of corneal endothelial cells in the presence of silicone oil in the anterior chamber10.1038/s41598-021-93338-x2045-2322https://doaj.org/article/d204df69a6d1454d832ffea47d3410bc2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93338-xhttps://doaj.org/toc/2045-2322Abstract To evaluate corneal endothelium damage with silicone oil (SO) presence in the anterior chamber after pars plana vitrectomy. We investigated the medical records of consecutive 54 eyes of 53 patients undergoing SO removal after pars plana vitrectomy with SO tamponade at Saitama Medical Center, Jichi Medical University, Japan. We recorded SO tamponade retention period, anterior chamber SO with gonioscope, area of SO attachment to the corneal endothelium before SO removal surgery, and the lens status. We then retrospectively investigated the correlation between SO presence in the anterior chamber and the decrease rate of corneal endothelial cell (CEC) density during SO tamponade. The average decrease rate of CEC density was 7.6 (0–38.1) %. The correlation between SO tamponade retention period and decrease rate of CEC density was high (p = 0.0001). However, there was no correlation between anterior chamber SO under gonioscope, SO attaching area, and lens status with the decrease rate of CEC density (p = 0.11, p = 0.93, p = 0.16). No correlation was observed between CEC loss and the existence of anterior chamber SO, although CEC decrease rate was relatively high after a long SO tamponade period. These findings suggest that SO presence in the anterior chamber may not directly injure CEC.Machiko Shimmura-TomitaHiroko TakanoYoshiaki TanakaRina TakagiToshikatsu KaburakiAkihiro KakehashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Machiko Shimmura-Tomita Hiroko Takano Yoshiaki Tanaka Rina Takagi Toshikatsu Kaburaki Akihiro Kakehashi Status of corneal endothelial cells in the presence of silicone oil in the anterior chamber
description	Abstract To evaluate corneal endothelium damage with silicone oil (SO) presence in the anterior chamber after pars plana vitrectomy. We investigated the medical records of consecutive 54 eyes of 53 patients undergoing SO removal after pars plana vitrectomy with SO tamponade at Saitama Medical Center, Jichi Medical University, Japan. We recorded SO tamponade retention period, anterior chamber SO with gonioscope, area of SO attachment to the corneal endothelium before SO removal surgery, and the lens status. We then retrospectively investigated the correlation between SO presence in the anterior chamber and the decrease rate of corneal endothelial cell (CEC) density during SO tamponade. The average decrease rate of CEC density was 7.6 (0–38.1) %. The correlation between SO tamponade retention period and decrease rate of CEC density was high (p = 0.0001). However, there was no correlation between anterior chamber SO under gonioscope, SO attaching area, and lens status with the decrease rate of CEC density (p = 0.11, p = 0.93, p = 0.16). No correlation was observed between CEC loss and the existence of anterior chamber SO, although CEC decrease rate was relatively high after a long SO tamponade period. These findings suggest that SO presence in the anterior chamber may not directly injure CEC.
format	article
author	Machiko Shimmura-Tomita Hiroko Takano Yoshiaki Tanaka Rina Takagi Toshikatsu Kaburaki Akihiro Kakehashi
author_facet	Machiko Shimmura-Tomita Hiroko Takano Yoshiaki Tanaka Rina Takagi Toshikatsu Kaburaki Akihiro Kakehashi
author_sort	Machiko Shimmura-Tomita
title	Status of corneal endothelial cells in the presence of silicone oil in the anterior chamber
title_short	Status of corneal endothelial cells in the presence of silicone oil in the anterior chamber
title_full	Status of corneal endothelial cells in the presence of silicone oil in the anterior chamber
title_fullStr	Status of corneal endothelial cells in the presence of silicone oil in the anterior chamber
title_full_unstemmed	Status of corneal endothelial cells in the presence of silicone oil in the anterior chamber
title_sort	status of corneal endothelial cells in the presence of silicone oil in the anterior chamber
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d204df69a6d1454d832ffea47d3410bc
work_keys_str_mv	AT machikoshimmuratomita statusofcornealendothelialcellsinthepresenceofsiliconeoilintheanteriorchamber AT hirokotakano statusofcornealendothelialcellsinthepresenceofsiliconeoilintheanteriorchamber AT yoshiakitanaka statusofcornealendothelialcellsinthepresenceofsiliconeoilintheanteriorchamber AT rinatakagi statusofcornealendothelialcellsinthepresenceofsiliconeoilintheanteriorchamber AT toshikatsukaburaki statusofcornealendothelialcellsinthepresenceofsiliconeoilintheanteriorchamber AT akihirokakehashi statusofcornealendothelialcellsinthepresenceofsiliconeoilintheanteriorchamber
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Status of corneal endothelial cells in the presence of silicone oil in the anterior chamber

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