Septin Remodeling During Mammalian Cytokinesis

Cytokinesis mediates the final separation of a mother cell into two daughter cells. Septins are recruited to the cleavage furrow at an early stage. During cytokinetic progression the septin cytoskeleton is constantly rearranged, ultimately leading to a concentration of septins within the intercellul...

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Autores principales:	Giulia Russo, Michael Krauss
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	septins cytokinesis actomyosin microtubules phosphoinositides Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d20826a91b2e4dea932682d947d475f8
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spelling	oai:doaj.org-article:d20826a91b2e4dea932682d947d475f82021-11-04T07:33:59ZSeptin Remodeling During Mammalian Cytokinesis2296-634X10.3389/fcell.2021.768309https://doaj.org/article/d20826a91b2e4dea932682d947d475f82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.768309/fullhttps://doaj.org/toc/2296-634XCytokinesis mediates the final separation of a mother cell into two daughter cells. Septins are recruited to the cleavage furrow at an early stage. During cytokinetic progression the septin cytoskeleton is constantly rearranged, ultimately leading to a concentration of septins within the intercellular bridge (ICB), and to the formation of two rings adjacent to the midbody that aid ESCRT-dependent abscission. The molecular mechanisms underlying this behavior are poorly understood. Based on observations that septins can associate with actin, microtubules and associated motors, we review here established roles of septins in mammalian cytokinesis, and discuss, how septins may support cytokinetic progression by exerting their functions at particular sites. Finally, we discuss how this might be assisted by phosphoinositide-metabolizing enzymes.Giulia RussoMichael KraussFrontiers Media S.A.articleseptinscytokinesisactomyosinmicrotubulesphosphoinositidesBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	septins cytokinesis actomyosin microtubules phosphoinositides Biology (General) QH301-705.5
spellingShingle	septins cytokinesis actomyosin microtubules phosphoinositides Biology (General) QH301-705.5 Giulia Russo Michael Krauss Septin Remodeling During Mammalian Cytokinesis
description	Cytokinesis mediates the final separation of a mother cell into two daughter cells. Septins are recruited to the cleavage furrow at an early stage. During cytokinetic progression the septin cytoskeleton is constantly rearranged, ultimately leading to a concentration of septins within the intercellular bridge (ICB), and to the formation of two rings adjacent to the midbody that aid ESCRT-dependent abscission. The molecular mechanisms underlying this behavior are poorly understood. Based on observations that septins can associate with actin, microtubules and associated motors, we review here established roles of septins in mammalian cytokinesis, and discuss, how septins may support cytokinetic progression by exerting their functions at particular sites. Finally, we discuss how this might be assisted by phosphoinositide-metabolizing enzymes.
format	article
author	Giulia Russo Michael Krauss
author_facet	Giulia Russo Michael Krauss
author_sort	Giulia Russo
title	Septin Remodeling During Mammalian Cytokinesis
title_short	Septin Remodeling During Mammalian Cytokinesis
title_full	Septin Remodeling During Mammalian Cytokinesis
title_fullStr	Septin Remodeling During Mammalian Cytokinesis
title_full_unstemmed	Septin Remodeling During Mammalian Cytokinesis
title_sort	septin remodeling during mammalian cytokinesis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d20826a91b2e4dea932682d947d475f8
work_keys_str_mv	AT giuliarusso septinremodelingduringmammaliancytokinesis AT michaelkrauss septinremodelingduringmammaliancytokinesis
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Septin Remodeling During Mammalian Cytokinesis

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