SOME FEATURES OF CHANGING TELOMERE LENGTH IN LYMPHOCYTES FROM THE PATIENTS WITH BRONCHIAL ASTHMA

Abstract. A significant telomere shortening was shown in both total peripheral lymphocyte populations and CD4+ T-cells from patients with bronchial asthma, as compared to normal donors. Such shortening takes place in different cell subpopulations depends on different types of bronchial asthma. In pa...

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Autores principales:	V. I. Borisov, S. A. Demakov, V. M. Nepomnyashchikh, M. I. Leonova, D. V. Demina, N. A. Barovskaya, V. S. Kozhevnikov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	telomere bronchial asthma lymphocytes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d2087a14955d43e68ab872b72a30375e
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spelling	oai:doaj.org-article:d2087a14955d43e68ab872b72a30375e2021-11-18T08:03:40ZSOME FEATURES OF CHANGING TELOMERE LENGTH IN LYMPHOCYTES FROM THE PATIENTS WITH BRONCHIAL ASTHMA1563-06252313-741X10.15789/1563-0625-2009-6-523-530https://doaj.org/article/d2087a14955d43e68ab872b72a30375e2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/357https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. A significant telomere shortening was shown in both total peripheral lymphocyte populations and CD4+ T-cells from patients with bronchial asthma, as compared to normal donors. Such shortening takes place in different cell subpopulations depends on different types of bronchial asthma. In patients with intrinsic asthma, a telomere contraction was found both in CD4+ and CD8+T-lymphocytes, but only in CD4+ lymphocytes from patients with extrinsic-type asthma. We didn’t found any changes of telomere length in patients with mixed-type asthma, however, a significant correlation was found between telomere length in both CD4+ and CD8+T- cells, and serum IgE concentrations.The data obtained demonstrate that telomere shortening in lymphocytes may take place not only due to T-cell exhaustion, or homeostatic proliferation induced by lymphopenia, but also due to expansion of antigenreacting cells. The entire data point to sufficient pathogenetic differences for various types of bronchial asthma. A non-uniform contribution of atopic and infectious inflammation may present an important reason for different patterns of the disease development.V. I. BorisovS. A. DemakovV. M. NepomnyashchikhM. I. LeonovaD. V. DeminaN. A. BarovskayaV. S. KozhevnikovSPb RAACIarticletelomerebronchial asthmalymphocytesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 6, Pp 523-530 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	telomere bronchial asthma lymphocytes Immunologic diseases. Allergy RC581-607
spellingShingle	telomere bronchial asthma lymphocytes Immunologic diseases. Allergy RC581-607 V. I. Borisov S. A. Demakov V. M. Nepomnyashchikh M. I. Leonova D. V. Demina N. A. Barovskaya V. S. Kozhevnikov SOME FEATURES OF CHANGING TELOMERE LENGTH IN LYMPHOCYTES FROM THE PATIENTS WITH BRONCHIAL ASTHMA
description	Abstract. A significant telomere shortening was shown in both total peripheral lymphocyte populations and CD4+ T-cells from patients with bronchial asthma, as compared to normal donors. Such shortening takes place in different cell subpopulations depends on different types of bronchial asthma. In patients with intrinsic asthma, a telomere contraction was found both in CD4+ and CD8+T-lymphocytes, but only in CD4+ lymphocytes from patients with extrinsic-type asthma. We didn’t found any changes of telomere length in patients with mixed-type asthma, however, a significant correlation was found between telomere length in both CD4+ and CD8+T- cells, and serum IgE concentrations.The data obtained demonstrate that telomere shortening in lymphocytes may take place not only due to T-cell exhaustion, or homeostatic proliferation induced by lymphopenia, but also due to expansion of antigenreacting cells. The entire data point to sufficient pathogenetic differences for various types of bronchial asthma. A non-uniform contribution of atopic and infectious inflammation may present an important reason for different patterns of the disease development.
format	article
author	V. I. Borisov S. A. Demakov V. M. Nepomnyashchikh M. I. Leonova D. V. Demina N. A. Barovskaya V. S. Kozhevnikov
author_facet	V. I. Borisov S. A. Demakov V. M. Nepomnyashchikh M. I. Leonova D. V. Demina N. A. Barovskaya V. S. Kozhevnikov
author_sort	V. I. Borisov
title	SOME FEATURES OF CHANGING TELOMERE LENGTH IN LYMPHOCYTES FROM THE PATIENTS WITH BRONCHIAL ASTHMA
title_short	SOME FEATURES OF CHANGING TELOMERE LENGTH IN LYMPHOCYTES FROM THE PATIENTS WITH BRONCHIAL ASTHMA
title_full	SOME FEATURES OF CHANGING TELOMERE LENGTH IN LYMPHOCYTES FROM THE PATIENTS WITH BRONCHIAL ASTHMA
title_fullStr	SOME FEATURES OF CHANGING TELOMERE LENGTH IN LYMPHOCYTES FROM THE PATIENTS WITH BRONCHIAL ASTHMA
title_full_unstemmed	SOME FEATURES OF CHANGING TELOMERE LENGTH IN LYMPHOCYTES FROM THE PATIENTS WITH BRONCHIAL ASTHMA
title_sort	some features of changing telomere length in lymphocytes from the patients with bronchial asthma
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/d2087a14955d43e68ab872b72a30375e
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_version_	1718422510549073920

SOME FEATURES OF CHANGING TELOMERE LENGTH IN LYMPHOCYTES FROM THE PATIENTS WITH BRONCHIAL ASTHMA

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