Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes
There are dynamic interactions between immune cells and β cells that lead to β cell destruction in the context of autoimmune diabetes. Here the authors show that TET2, a methylcytosine dioxygenase, can regulate this interaction and deletion of TET2 can prevent the autoimmune destruction of β cells i...
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Nature Portfolio
2021
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oai:doaj.org-article:d2099481cf7c45539fc5dd7688d095112021-12-02T15:10:51ZTet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes10.1038/s41467-021-25367-z2041-1723https://doaj.org/article/d2099481cf7c45539fc5dd7688d095112021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25367-zhttps://doaj.org/toc/2041-1723There are dynamic interactions between immune cells and β cells that lead to β cell destruction in the context of autoimmune diabetes. Here the authors show that TET2, a methylcytosine dioxygenase, can regulate this interaction and deletion of TET2 can prevent the autoimmune destruction of β cells in mice.Jinxiu RuiSongyan DengAna Luisa PerdigotoGerald PonathRomy KursaweNathan LawlorTomokazu SumidaMaya Levine-RittermanMichael L. StitzelDavid PittJun LuKevan C. HeroldNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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Science Q Jinxiu Rui Songyan Deng Ana Luisa Perdigoto Gerald Ponath Romy Kursawe Nathan Lawlor Tomokazu Sumida Maya Levine-Ritterman Michael L. Stitzel David Pitt Jun Lu Kevan C. Herold Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes |
description |
There are dynamic interactions between immune cells and β cells that lead to β cell destruction in the context of autoimmune diabetes. Here the authors show that TET2, a methylcytosine dioxygenase, can regulate this interaction and deletion of TET2 can prevent the autoimmune destruction of β cells in mice. |
format |
article |
author |
Jinxiu Rui Songyan Deng Ana Luisa Perdigoto Gerald Ponath Romy Kursawe Nathan Lawlor Tomokazu Sumida Maya Levine-Ritterman Michael L. Stitzel David Pitt Jun Lu Kevan C. Herold |
author_facet |
Jinxiu Rui Songyan Deng Ana Luisa Perdigoto Gerald Ponath Romy Kursawe Nathan Lawlor Tomokazu Sumida Maya Levine-Ritterman Michael L. Stitzel David Pitt Jun Lu Kevan C. Herold |
author_sort |
Jinxiu Rui |
title |
Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes |
title_short |
Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes |
title_full |
Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes |
title_fullStr |
Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes |
title_full_unstemmed |
Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes |
title_sort |
tet2 controls the responses of β cells to inflammation in autoimmune diabetes |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/d2099481cf7c45539fc5dd7688d09511 |
work_keys_str_mv |
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