Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes

There are dynamic interactions between immune cells and β cells that lead to β cell destruction in the context of autoimmune diabetes. Here the authors show that TET2, a methylcytosine dioxygenase, can regulate this interaction and deletion of TET2 can prevent the autoimmune destruction of β cells i...

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Autores principales:	Jinxiu Rui, Songyan Deng, Ana Luisa Perdigoto, Gerald Ponath, Romy Kursawe, Nathan Lawlor, Tomokazu Sumida, Maya Levine-Ritterman, Michael L. Stitzel, David Pitt, Jun Lu, Kevan C. Herold
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d2099481cf7c45539fc5dd7688d09511
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spelling	oai:doaj.org-article:d2099481cf7c45539fc5dd7688d095112021-12-02T15:10:51ZTet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes10.1038/s41467-021-25367-z2041-1723https://doaj.org/article/d2099481cf7c45539fc5dd7688d095112021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25367-zhttps://doaj.org/toc/2041-1723There are dynamic interactions between immune cells and β cells that lead to β cell destruction in the context of autoimmune diabetes. Here the authors show that TET2, a methylcytosine dioxygenase, can regulate this interaction and deletion of TET2 can prevent the autoimmune destruction of β cells in mice.Jinxiu RuiSongyan DengAna Luisa PerdigotoGerald PonathRomy KursaweNathan LawlorTomokazu SumidaMaya Levine-RittermanMichael L. StitzelDavid PittJun LuKevan C. HeroldNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinxiu Rui Songyan Deng Ana Luisa Perdigoto Gerald Ponath Romy Kursawe Nathan Lawlor Tomokazu Sumida Maya Levine-Ritterman Michael L. Stitzel David Pitt Jun Lu Kevan C. Herold Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes
description	There are dynamic interactions between immune cells and β cells that lead to β cell destruction in the context of autoimmune diabetes. Here the authors show that TET2, a methylcytosine dioxygenase, can regulate this interaction and deletion of TET2 can prevent the autoimmune destruction of β cells in mice.
format	article
author	Jinxiu Rui Songyan Deng Ana Luisa Perdigoto Gerald Ponath Romy Kursawe Nathan Lawlor Tomokazu Sumida Maya Levine-Ritterman Michael L. Stitzel David Pitt Jun Lu Kevan C. Herold
author_facet	Jinxiu Rui Songyan Deng Ana Luisa Perdigoto Gerald Ponath Romy Kursawe Nathan Lawlor Tomokazu Sumida Maya Levine-Ritterman Michael L. Stitzel David Pitt Jun Lu Kevan C. Herold
author_sort	Jinxiu Rui
title	Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes
title_short	Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes
title_full	Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes
title_fullStr	Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes
title_full_unstemmed	Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes
title_sort	tet2 controls the responses of β cells to inflammation in autoimmune diabetes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d2099481cf7c45539fc5dd7688d09511
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Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes

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