Potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes

Abstract Background Nonalcoholic fatty liver disease (NAFLD) is proved to be related to insulin resistance and type 2 diabetes, and it is also not rare in individuals without diabetes. The present study attempts to identify the metabolic risk factors of NAFLD among those individuals. Results ALT and...

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Autores principales:	H. Naguib, H. Kassab
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Insulin resistance Triglycerides to high-density lipoprotein ratio Glycosylated hemoglobin Nonalcoholic fatty liver disease Surgery RD1-811 Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/d20c5e9e86954c20a184c1b9aa666af8
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spelling	oai:doaj.org-article:d20c5e9e86954c20a184c1b9aa666af82021-11-28T12:21:59ZPotential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes10.1186/s43066-021-00154-z2090-6226https://doaj.org/article/d20c5e9e86954c20a184c1b9aa666af82021-11-01T00:00:00Zhttps://doi.org/10.1186/s43066-021-00154-zhttps://doaj.org/toc/2090-6226Abstract Background Nonalcoholic fatty liver disease (NAFLD) is proved to be related to insulin resistance and type 2 diabetes, and it is also not rare in individuals without diabetes. The present study attempts to identify the metabolic risk factors of NAFLD among those individuals. Results ALT and HbA1c levels were independently associated with NAFLD development in individuals without diabetes. Receiver operating characteristic (ROC) analysis identified the optimal cutoff point of ALT (> 19 IU/ml) with AUC = 0.731, 95% CI 0.653–0.809. On the other hand, the optimal cutoff point of HbA1c was identified to be > 5.1% with AUC = 0.665, 95% CI 0.581–0.750. Conclusions Early identification of NAFLD among subjects without diabetes is crucial. In this study, ALT and HbA1c cutoff values had been identified, so we suggest that inclusion of both HbA1c and ALT levels may have significant implications for prediction of NAFLD among individuals without diabetes.H. NaguibH. KassabSpringerOpenarticleInsulin resistanceTriglycerides to high-density lipoprotein ratioGlycosylated hemoglobinNonalcoholic fatty liver diseaseSurgeryRD1-811Diseases of the digestive system. GastroenterologyRC799-869ENEgyptian Liver Journal, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Insulin resistance Triglycerides to high-density lipoprotein ratio Glycosylated hemoglobin Nonalcoholic fatty liver disease Surgery RD1-811 Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Insulin resistance Triglycerides to high-density lipoprotein ratio Glycosylated hemoglobin Nonalcoholic fatty liver disease Surgery RD1-811 Diseases of the digestive system. Gastroenterology RC799-869 H. Naguib H. Kassab Potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes
description	Abstract Background Nonalcoholic fatty liver disease (NAFLD) is proved to be related to insulin resistance and type 2 diabetes, and it is also not rare in individuals without diabetes. The present study attempts to identify the metabolic risk factors of NAFLD among those individuals. Results ALT and HbA1c levels were independently associated with NAFLD development in individuals without diabetes. Receiver operating characteristic (ROC) analysis identified the optimal cutoff point of ALT (> 19 IU/ml) with AUC = 0.731, 95% CI 0.653–0.809. On the other hand, the optimal cutoff point of HbA1c was identified to be > 5.1% with AUC = 0.665, 95% CI 0.581–0.750. Conclusions Early identification of NAFLD among subjects without diabetes is crucial. In this study, ALT and HbA1c cutoff values had been identified, so we suggest that inclusion of both HbA1c and ALT levels may have significant implications for prediction of NAFLD among individuals without diabetes.
format	article
author	H. Naguib H. Kassab
author_facet	H. Naguib H. Kassab
author_sort	H. Naguib
title	Potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes
title_short	Potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes
title_full	Potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes
title_fullStr	Potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes
title_full_unstemmed	Potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes
title_sort	potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/d20c5e9e86954c20a184c1b9aa666af8
work_keys_str_mv	AT hnaguib potentialrelationbetweennonalcoholicfattyliverdiseaseandglycemicandmetabolicparametersinsubjectswithoutdiabetes AT hkassab potentialrelationbetweennonalcoholicfattyliverdiseaseandglycemicandmetabolicparametersinsubjectswithoutdiabetes
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Potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes

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