Potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is proved to be related to insulin resistance and type 2 diabetes, and it is also not rare in individuals without diabetes. The present study attempts to identify the metabolic risk factors of NAFLD among those individuals. Results ALT and...
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oai:doaj.org-article:d20c5e9e86954c20a184c1b9aa666af82021-11-28T12:21:59ZPotential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes10.1186/s43066-021-00154-z2090-6226https://doaj.org/article/d20c5e9e86954c20a184c1b9aa666af82021-11-01T00:00:00Zhttps://doi.org/10.1186/s43066-021-00154-zhttps://doaj.org/toc/2090-6226Abstract Background Nonalcoholic fatty liver disease (NAFLD) is proved to be related to insulin resistance and type 2 diabetes, and it is also not rare in individuals without diabetes. The present study attempts to identify the metabolic risk factors of NAFLD among those individuals. Results ALT and HbA1c levels were independently associated with NAFLD development in individuals without diabetes. Receiver operating characteristic (ROC) analysis identified the optimal cutoff point of ALT (> 19 IU/ml) with AUC = 0.731, 95% CI 0.653–0.809. On the other hand, the optimal cutoff point of HbA1c was identified to be > 5.1% with AUC = 0.665, 95% CI 0.581–0.750. Conclusions Early identification of NAFLD among subjects without diabetes is crucial. In this study, ALT and HbA1c cutoff values had been identified, so we suggest that inclusion of both HbA1c and ALT levels may have significant implications for prediction of NAFLD among individuals without diabetes.H. NaguibH. KassabSpringerOpenarticleInsulin resistanceTriglycerides to high-density lipoprotein ratioGlycosylated hemoglobinNonalcoholic fatty liver diseaseSurgeryRD1-811Diseases of the digestive system. GastroenterologyRC799-869ENEgyptian Liver Journal, Vol 11, Iss 1, Pp 1-7 (2021) |
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Insulin resistance Triglycerides to high-density lipoprotein ratio Glycosylated hemoglobin Nonalcoholic fatty liver disease Surgery RD1-811 Diseases of the digestive system. Gastroenterology RC799-869 |
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Insulin resistance Triglycerides to high-density lipoprotein ratio Glycosylated hemoglobin Nonalcoholic fatty liver disease Surgery RD1-811 Diseases of the digestive system. Gastroenterology RC799-869 H. Naguib H. Kassab Potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes |
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Abstract Background Nonalcoholic fatty liver disease (NAFLD) is proved to be related to insulin resistance and type 2 diabetes, and it is also not rare in individuals without diabetes. The present study attempts to identify the metabolic risk factors of NAFLD among those individuals. Results ALT and HbA1c levels were independently associated with NAFLD development in individuals without diabetes. Receiver operating characteristic (ROC) analysis identified the optimal cutoff point of ALT (> 19 IU/ml) with AUC = 0.731, 95% CI 0.653–0.809. On the other hand, the optimal cutoff point of HbA1c was identified to be > 5.1% with AUC = 0.665, 95% CI 0.581–0.750. Conclusions Early identification of NAFLD among subjects without diabetes is crucial. In this study, ALT and HbA1c cutoff values had been identified, so we suggest that inclusion of both HbA1c and ALT levels may have significant implications for prediction of NAFLD among individuals without diabetes. |
format |
article |
author |
H. Naguib H. Kassab |
author_facet |
H. Naguib H. Kassab |
author_sort |
H. Naguib |
title |
Potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes |
title_short |
Potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes |
title_full |
Potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes |
title_fullStr |
Potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes |
title_full_unstemmed |
Potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes |
title_sort |
potential relation between non-alcoholic fatty liver disease and glycemic and metabolic parameters in subjects without diabetes |
publisher |
SpringerOpen |
publishDate |
2021 |
url |
https://doaj.org/article/d20c5e9e86954c20a184c1b9aa666af8 |
work_keys_str_mv |
AT hnaguib potentialrelationbetweennonalcoholicfattyliverdiseaseandglycemicandmetabolicparametersinsubjectswithoutdiabetes AT hkassab potentialrelationbetweennonalcoholicfattyliverdiseaseandglycemicandmetabolicparametersinsubjectswithoutdiabetes |
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