Place Cell-Like Activity in the Primary Sensorimotor and Premotor Cortex During Monkey Whole-Body Navigation

Abstract Primary motor (M1), primary somatosensory (S1) and dorsal premotor (PMd) cortical areas of rhesus monkeys previously have been associated only with sensorimotor control of limb movements. Here we show that a significant number of neurons in these areas also represent body position and orien...

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Autores principales:	A. Yin, P. H. Tseng, S. Rajangam, M. A. Lebedev, M. A. L. Nicolelis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d20db36e385b48aebc128c55638d3835
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spelling	oai:doaj.org-article:d20db36e385b48aebc128c55638d38352021-12-02T15:08:36ZPlace Cell-Like Activity in the Primary Sensorimotor and Premotor Cortex During Monkey Whole-Body Navigation10.1038/s41598-018-27472-42045-2322https://doaj.org/article/d20db36e385b48aebc128c55638d38352018-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-27472-4https://doaj.org/toc/2045-2322Abstract Primary motor (M1), primary somatosensory (S1) and dorsal premotor (PMd) cortical areas of rhesus monkeys previously have been associated only with sensorimotor control of limb movements. Here we show that a significant number of neurons in these areas also represent body position and orientation in space. Two rhesus monkeys (K and M) used a wheelchair controlled by a brain-machine interface (BMI) to navigate in a room. During this whole-body navigation, the discharge rates of M1, S1, and PMd neurons correlated with the two-dimensional (2D) room position and the direction of the wheelchair and the monkey head. This place cell-like activity was observed in both monkeys, with 44.6% and 33.3% of neurons encoding room position in monkeys K and M, respectively, and the overlapping populations of 41.0% and 16.0% neurons encoding head direction. These observations suggest that primary sensorimotor and premotor cortical areas in primates are likely involved in allocentrically representing body position in space during whole-body navigation, which is an unexpected finding given the classical hierarchical model of cortical processing that attributes functional specialization for spatial processing to the hippocampal formation.A. YinP. H. TsengS. RajangamM. A. LebedevM. A. L. NicolelisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. Yin P. H. Tseng S. Rajangam M. A. Lebedev M. A. L. Nicolelis Place Cell-Like Activity in the Primary Sensorimotor and Premotor Cortex During Monkey Whole-Body Navigation
description	Abstract Primary motor (M1), primary somatosensory (S1) and dorsal premotor (PMd) cortical areas of rhesus monkeys previously have been associated only with sensorimotor control of limb movements. Here we show that a significant number of neurons in these areas also represent body position and orientation in space. Two rhesus monkeys (K and M) used a wheelchair controlled by a brain-machine interface (BMI) to navigate in a room. During this whole-body navigation, the discharge rates of M1, S1, and PMd neurons correlated with the two-dimensional (2D) room position and the direction of the wheelchair and the monkey head. This place cell-like activity was observed in both monkeys, with 44.6% and 33.3% of neurons encoding room position in monkeys K and M, respectively, and the overlapping populations of 41.0% and 16.0% neurons encoding head direction. These observations suggest that primary sensorimotor and premotor cortical areas in primates are likely involved in allocentrically representing body position in space during whole-body navigation, which is an unexpected finding given the classical hierarchical model of cortical processing that attributes functional specialization for spatial processing to the hippocampal formation.
format	article
author	A. Yin P. H. Tseng S. Rajangam M. A. Lebedev M. A. L. Nicolelis
author_facet	A. Yin P. H. Tseng S. Rajangam M. A. Lebedev M. A. L. Nicolelis
author_sort	A. Yin
title	Place Cell-Like Activity in the Primary Sensorimotor and Premotor Cortex During Monkey Whole-Body Navigation
title_short	Place Cell-Like Activity in the Primary Sensorimotor and Premotor Cortex During Monkey Whole-Body Navigation
title_full	Place Cell-Like Activity in the Primary Sensorimotor and Premotor Cortex During Monkey Whole-Body Navigation
title_fullStr	Place Cell-Like Activity in the Primary Sensorimotor and Premotor Cortex During Monkey Whole-Body Navigation
title_full_unstemmed	Place Cell-Like Activity in the Primary Sensorimotor and Premotor Cortex During Monkey Whole-Body Navigation
title_sort	place cell-like activity in the primary sensorimotor and premotor cortex during monkey whole-body navigation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d20db36e385b48aebc128c55638d3835
work_keys_str_mv	AT ayin placecelllikeactivityintheprimarysensorimotorandpremotorcortexduringmonkeywholebodynavigation AT phtseng placecelllikeactivityintheprimarysensorimotorandpremotorcortexduringmonkeywholebodynavigation AT srajangam placecelllikeactivityintheprimarysensorimotorandpremotorcortexduringmonkeywholebodynavigation AT malebedev placecelllikeactivityintheprimarysensorimotorandpremotorcortexduringmonkeywholebodynavigation AT malnicolelis placecelllikeactivityintheprimarysensorimotorandpremotorcortexduringmonkeywholebodynavigation
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Place Cell-Like Activity in the Primary Sensorimotor and Premotor Cortex During Monkey Whole-Body Navigation

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