Cryobiopsy in the diagnosis of bronchiolitis: a retrospective analysis of twenty-three consecutive patients

Abstract Bronchiolitis manifests as a variety of histological features that explain the complex clinical profiles and imaging aspects. In the period between January 2011 and June 2015, patients with a cryobiopsy diagnosis of bronchiolitis were retrospectively retrieved from the database of our insti...

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Autores principales: Syakirin Sirol Aflah Syazatul, Sara Piciucchi, Sara Tomassetti, Claudia Ravaglia, Alessandra Dubini, Venerino Poletti
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Publicado: Nature Portfolio 2020
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spelling oai:doaj.org-article:d2122988bc534968b33737a1649b37aa2021-12-02T18:18:50ZCryobiopsy in the diagnosis of bronchiolitis: a retrospective analysis of twenty-three consecutive patients10.1038/s41598-020-67938-y2045-2322https://doaj.org/article/d2122988bc534968b33737a1649b37aa2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-67938-yhttps://doaj.org/toc/2045-2322Abstract Bronchiolitis manifests as a variety of histological features that explain the complex clinical profiles and imaging aspects. In the period between January 2011 and June 2015, patients with a cryobiopsy diagnosis of bronchiolitis were retrospectively retrieved from the database of our institution. Clinical profiles, imaging features and histologic diagnoses were analysed to identify the role of cryobiopsy in the diagnostic process. Twenty-three patients with a multidisciplinary diagnosis of small airway disease were retrieved (14 females, 9 males; age range 31–74 years old; mean age 54.2 years old). The final MDT diagnoses were post-infectious bronchiolitis (n = 5), constrictive bronchiolitis (n = 3), DIPNECH (n = 1), idiopathic follicular bronchiolitis (n = 3), Sjogren’s disease (n = 1), GLILD (n = 1), smoking-related interstitial lung disease (n = 6), sarcoid with granulomatous bronchiolar disorder (n = 1), and subacute hypersensitivity pneumonitis (n = 2). Complications reported after the cryobiopsy procedure consisted of two cases of pneumothorax soon after the biopsy (8.7%), which were successfully managed with the insertion of a chest tube. Transbronchial cryobiopsy represents a robust and mini-invasive method in the characterization of small airway diseases, allowing a low percentage of complications and good diagnostic confidence.Syakirin Sirol Aflah SyazatulSara PiciucchiSara TomassettiClaudia RavagliaAlessandra DubiniVenerino PolettiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Syakirin Sirol Aflah Syazatul
Sara Piciucchi
Sara Tomassetti
Claudia Ravaglia
Alessandra Dubini
Venerino Poletti
Cryobiopsy in the diagnosis of bronchiolitis: a retrospective analysis of twenty-three consecutive patients
description Abstract Bronchiolitis manifests as a variety of histological features that explain the complex clinical profiles and imaging aspects. In the period between January 2011 and June 2015, patients with a cryobiopsy diagnosis of bronchiolitis were retrospectively retrieved from the database of our institution. Clinical profiles, imaging features and histologic diagnoses were analysed to identify the role of cryobiopsy in the diagnostic process. Twenty-three patients with a multidisciplinary diagnosis of small airway disease were retrieved (14 females, 9 males; age range 31–74 years old; mean age 54.2 years old). The final MDT diagnoses were post-infectious bronchiolitis (n = 5), constrictive bronchiolitis (n = 3), DIPNECH (n = 1), idiopathic follicular bronchiolitis (n = 3), Sjogren’s disease (n = 1), GLILD (n = 1), smoking-related interstitial lung disease (n = 6), sarcoid with granulomatous bronchiolar disorder (n = 1), and subacute hypersensitivity pneumonitis (n = 2). Complications reported after the cryobiopsy procedure consisted of two cases of pneumothorax soon after the biopsy (8.7%), which were successfully managed with the insertion of a chest tube. Transbronchial cryobiopsy represents a robust and mini-invasive method in the characterization of small airway diseases, allowing a low percentage of complications and good diagnostic confidence.
format article
author Syakirin Sirol Aflah Syazatul
Sara Piciucchi
Sara Tomassetti
Claudia Ravaglia
Alessandra Dubini
Venerino Poletti
author_facet Syakirin Sirol Aflah Syazatul
Sara Piciucchi
Sara Tomassetti
Claudia Ravaglia
Alessandra Dubini
Venerino Poletti
author_sort Syakirin Sirol Aflah Syazatul
title Cryobiopsy in the diagnosis of bronchiolitis: a retrospective analysis of twenty-three consecutive patients
title_short Cryobiopsy in the diagnosis of bronchiolitis: a retrospective analysis of twenty-three consecutive patients
title_full Cryobiopsy in the diagnosis of bronchiolitis: a retrospective analysis of twenty-three consecutive patients
title_fullStr Cryobiopsy in the diagnosis of bronchiolitis: a retrospective analysis of twenty-three consecutive patients
title_full_unstemmed Cryobiopsy in the diagnosis of bronchiolitis: a retrospective analysis of twenty-three consecutive patients
title_sort cryobiopsy in the diagnosis of bronchiolitis: a retrospective analysis of twenty-three consecutive patients
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/d2122988bc534968b33737a1649b37aa
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