Reduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis
Abstract Multiple factors regulate glucagon-like peptide-1 (GLP-1) secretion, but a group of apparently healthy subjects showed blunted responses of GLP-1 secretion in our previous study. In this study, we examined whether the reduction in GLP-1 secretory capacity is associated with increased extent...
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Nature Portfolio
2021
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oai:doaj.org-article:d2126c0c6ea34c039df8a5df2462ede22021-12-02T16:35:37ZReduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis10.1038/s41598-021-95065-92045-2322https://doaj.org/article/d2126c0c6ea34c039df8a5df2462ede22021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95065-9https://doaj.org/toc/2045-2322Abstract Multiple factors regulate glucagon-like peptide-1 (GLP-1) secretion, but a group of apparently healthy subjects showed blunted responses of GLP-1 secretion in our previous study. In this study, we examined whether the reduction in GLP-1 secretory capacity is associated with increased extent of coronary artery stenosis in non-diabetic patients. Non-diabetic patients who were admitted for coronary angiography without a history of coronary interventions were enrolled. Coronary artery stenosis was quantified by Gensini score (GS), and GS ≥ 10 was used as an outcome variable based on its predictive value for cardiovascular events. The patients (mean age, 66.5 ± 8.8 years; 71% males, n = 173) underwent oral 75 g-glucose tolerant tests for determination of glucose, insulin and active GLP-1 levels. The area under the curve of plasma active GLP-1 (AUC-GLP-1) was determined as an index of GLP-1 secretory capacity. AUC-GLP-1 was not correlated with fasting glucose, AUC-glucose, serum lipids or indices of insulin sensitivity. In multivariate logistic regression analysis for GS ≥ 10, AUC-GLP-1 < median, age and hypertension were selected as explanatory variables, though fasting GLP-1 level was not selected. The findings suggest that reduction in GLP-1 secretory capacity is a novel independent risk factor of coronary stenosis.Chihiro NagaseMasaya TannoHidemichi KouzuTakayuki MikiJunichi NishidaNaoto MurakamiNobuaki KokubuNobutaka NaganoRyo NishikawaNobuhiro YoshiokaTohru HasegawaHiroyuki KitaAkihito TsuchidaHirofumi OhnishiTetsuji MiuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Chihiro Nagase Masaya Tanno Hidemichi Kouzu Takayuki Miki Junichi Nishida Naoto Murakami Nobuaki Kokubu Nobutaka Nagano Ryo Nishikawa Nobuhiro Yoshioka Tohru Hasegawa Hiroyuki Kita Akihito Tsuchida Hirofumi Ohnishi Tetsuji Miura Reduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis |
| description |
Abstract Multiple factors regulate glucagon-like peptide-1 (GLP-1) secretion, but a group of apparently healthy subjects showed blunted responses of GLP-1 secretion in our previous study. In this study, we examined whether the reduction in GLP-1 secretory capacity is associated with increased extent of coronary artery stenosis in non-diabetic patients. Non-diabetic patients who were admitted for coronary angiography without a history of coronary interventions were enrolled. Coronary artery stenosis was quantified by Gensini score (GS), and GS ≥ 10 was used as an outcome variable based on its predictive value for cardiovascular events. The patients (mean age, 66.5 ± 8.8 years; 71% males, n = 173) underwent oral 75 g-glucose tolerant tests for determination of glucose, insulin and active GLP-1 levels. The area under the curve of plasma active GLP-1 (AUC-GLP-1) was determined as an index of GLP-1 secretory capacity. AUC-GLP-1 was not correlated with fasting glucose, AUC-glucose, serum lipids or indices of insulin sensitivity. In multivariate logistic regression analysis for GS ≥ 10, AUC-GLP-1 < median, age and hypertension were selected as explanatory variables, though fasting GLP-1 level was not selected. The findings suggest that reduction in GLP-1 secretory capacity is a novel independent risk factor of coronary stenosis. |
| format |
article |
| author |
Chihiro Nagase Masaya Tanno Hidemichi Kouzu Takayuki Miki Junichi Nishida Naoto Murakami Nobuaki Kokubu Nobutaka Nagano Ryo Nishikawa Nobuhiro Yoshioka Tohru Hasegawa Hiroyuki Kita Akihito Tsuchida Hirofumi Ohnishi Tetsuji Miura |
| author_facet |
Chihiro Nagase Masaya Tanno Hidemichi Kouzu Takayuki Miki Junichi Nishida Naoto Murakami Nobuaki Kokubu Nobutaka Nagano Ryo Nishikawa Nobuhiro Yoshioka Tohru Hasegawa Hiroyuki Kita Akihito Tsuchida Hirofumi Ohnishi Tetsuji Miura |
| author_sort |
Chihiro Nagase |
| title |
Reduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis |
| title_short |
Reduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis |
| title_full |
Reduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis |
| title_fullStr |
Reduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis |
| title_full_unstemmed |
Reduction in GLP-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis |
| title_sort |
reduction in glp-1 secretory capacity may be a novel independent risk factor of coronary artery stenosis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d2126c0c6ea34c039df8a5df2462ede2 |
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