Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults

Abstract Objective Recent studies showed that genetic polymorphisms in the fat mass and obesity-associated gene (FTO) were associated with obesity and dietary intake. In this study of 71 adults in Jakarta, Indonesia, we investigated FTO rs1421085 association with body mass index (BMI), macronutrient...

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Autores principales:	Athraa Alaulddin Al-Jawadi, Lidwina Priliani, Sukma Oktavianthi, Clarissa A. Febinia, Mulianah Daya, I Made Artika, Safarina G. Malik
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	FTO rs1421085 Fatty acid Fat intake Obesity Indonesia Medicine R Biology (General) QH301-705.5 Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/d2177ab9f9354b598968859a92833a7b
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spelling	oai:doaj.org-article:d2177ab9f9354b598968859a92833a7b2021-11-14T12:28:41ZAssociation of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults10.1186/s13104-021-05823-11756-0500https://doaj.org/article/d2177ab9f9354b598968859a92833a7b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13104-021-05823-1https://doaj.org/toc/1756-0500Abstract Objective Recent studies showed that genetic polymorphisms in the fat mass and obesity-associated gene (FTO) were associated with obesity and dietary intake. In this study of 71 adults in Jakarta, Indonesia, we investigated FTO rs1421085 association with body mass index (BMI), macronutrient intake, and fatty acid intake. The association was evaluated using linear regression analyses assuming co-dominant, dominant, recessive, over-dominant, and additive genetic models. Results Only individuals with the CC genotype had a considerably higher BMI (p < 0.001), which indicates a recessive genetic trait, but the incidence for this genotype is low (68 TT + TC vs. 3 CC). Individuals with the minor C allele had an estimated increase of fat intake by 3.45–4.06% across various genetic models (dominant: p < 0.010, over-dominant: p < 0.030, additive: p < 0.010). Subjects with TC/CC genotypes had increased dietary monounsaturated fatty acid (MUFA; 1.14%, p = 0.046) and saturated fatty acid (SAFA; 2.06%, p = 0.023) intakes, compared to those with the TT genotype. In conclusion, our study provided evidence for the association between FTO rs1421085 risk allele with higher BMI and individual preferences for consuming more fat, MUFA, and SAFA. This study highlights the important role of FTO gene in food preference, and its influence on body weight.Athraa Alaulddin Al-JawadiLidwina PrilianiSukma OktavianthiClarissa A. FebiniaMulianah DayaI Made ArtikaSafarina G. MalikBMCarticleFTOrs1421085Fatty acidFat intakeObesityIndonesiaMedicineRBiology (General)QH301-705.5Science (General)Q1-390ENBMC Research Notes, Vol 14, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	FTO rs1421085 Fatty acid Fat intake Obesity Indonesia Medicine R Biology (General) QH301-705.5 Science (General) Q1-390
spellingShingle	FTO rs1421085 Fatty acid Fat intake Obesity Indonesia Medicine R Biology (General) QH301-705.5 Science (General) Q1-390 Athraa Alaulddin Al-Jawadi Lidwina Priliani Sukma Oktavianthi Clarissa A. Febinia Mulianah Daya I Made Artika Safarina G. Malik Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults
description	Abstract Objective Recent studies showed that genetic polymorphisms in the fat mass and obesity-associated gene (FTO) were associated with obesity and dietary intake. In this study of 71 adults in Jakarta, Indonesia, we investigated FTO rs1421085 association with body mass index (BMI), macronutrient intake, and fatty acid intake. The association was evaluated using linear regression analyses assuming co-dominant, dominant, recessive, over-dominant, and additive genetic models. Results Only individuals with the CC genotype had a considerably higher BMI (p < 0.001), which indicates a recessive genetic trait, but the incidence for this genotype is low (68 TT + TC vs. 3 CC). Individuals with the minor C allele had an estimated increase of fat intake by 3.45–4.06% across various genetic models (dominant: p < 0.010, over-dominant: p < 0.030, additive: p < 0.010). Subjects with TC/CC genotypes had increased dietary monounsaturated fatty acid (MUFA; 1.14%, p = 0.046) and saturated fatty acid (SAFA; 2.06%, p = 0.023) intakes, compared to those with the TT genotype. In conclusion, our study provided evidence for the association between FTO rs1421085 risk allele with higher BMI and individual preferences for consuming more fat, MUFA, and SAFA. This study highlights the important role of FTO gene in food preference, and its influence on body weight.
format	article
author	Athraa Alaulddin Al-Jawadi Lidwina Priliani Sukma Oktavianthi Clarissa A. Febinia Mulianah Daya I Made Artika Safarina G. Malik
author_facet	Athraa Alaulddin Al-Jawadi Lidwina Priliani Sukma Oktavianthi Clarissa A. Febinia Mulianah Daya I Made Artika Safarina G. Malik
author_sort	Athraa Alaulddin Al-Jawadi
title	Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults
title_short	Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults
title_full	Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults
title_fullStr	Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults
title_full_unstemmed	Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults
title_sort	association of fto rs1421085 single nucleotide polymorphism with fat and fatty acid intake in indonesian adults
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d2177ab9f9354b598968859a92833a7b
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Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults

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