A Comprehensive Review on the Interplay between <i>Neisseria</i> spp. and Host Sphingolipid Metabolites

Sphingolipids represent a class of structural related lipids involved in membrane biology and various cellular processes including cell growth, apoptosis, inflammation and migration. Over the past decade, sphingolipids have become the focus of intensive studies regarding their involvement in infecti...

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Autores principales:	Simon Peters, Ingo Fohmann, Thomas Rudel, Alexandra Schubert-Unkmeir
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sphingolipids <i>Neisseria meningitidis</i> <i>Neisseria gonorrhoeae</i> host–pathogen interaction Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d219393843ad47aa9ffa99bea3040830
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spelling	oai:doaj.org-article:d219393843ad47aa9ffa99bea30408302021-11-25T17:12:49ZA Comprehensive Review on the Interplay between <i>Neisseria</i> spp. and Host Sphingolipid Metabolites10.3390/cells101132012073-4409https://doaj.org/article/d219393843ad47aa9ffa99bea30408302021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3201https://doaj.org/toc/2073-4409Sphingolipids represent a class of structural related lipids involved in membrane biology and various cellular processes including cell growth, apoptosis, inflammation and migration. Over the past decade, sphingolipids have become the focus of intensive studies regarding their involvement in infectious diseases. Pathogens can manipulate the sphingolipid metabolism resulting in cell membrane reorganization and receptor recruitment to facilitate their entry. They may recruit specific host sphingolipid metabolites to establish a favorable niche for intracellular survival and proliferation. In contrast, some sphingolipid metabolites can also act as a first line defense against bacteria based on their antimicrobial activity. In this review, we will focus on the strategies employed by pathogenic <i>Neisseria</i> spp. to modulate the sphingolipid metabolism and hijack the sphingolipid balance in the host to promote cellular colonization, invasion and intracellular survival. Novel techniques and innovative approaches will be highlighted that allow imaging of sphingolipid derivatives in the host cell as well as in the pathogen.Simon PetersIngo FohmannThomas RudelAlexandra Schubert-UnkmeirMDPI AGarticlesphingolipids<i>Neisseria meningitidis</i><i>Neisseria gonorrhoeae</i>host–pathogen interactionBiology (General)QH301-705.5ENCells, Vol 10, Iss 3201, p 3201 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sphingolipids <i>Neisseria meningitidis</i> <i>Neisseria gonorrhoeae</i> host–pathogen interaction Biology (General) QH301-705.5
spellingShingle	sphingolipids <i>Neisseria meningitidis</i> <i>Neisseria gonorrhoeae</i> host–pathogen interaction Biology (General) QH301-705.5 Simon Peters Ingo Fohmann Thomas Rudel Alexandra Schubert-Unkmeir A Comprehensive Review on the Interplay between <i>Neisseria</i> spp. and Host Sphingolipid Metabolites
description	Sphingolipids represent a class of structural related lipids involved in membrane biology and various cellular processes including cell growth, apoptosis, inflammation and migration. Over the past decade, sphingolipids have become the focus of intensive studies regarding their involvement in infectious diseases. Pathogens can manipulate the sphingolipid metabolism resulting in cell membrane reorganization and receptor recruitment to facilitate their entry. They may recruit specific host sphingolipid metabolites to establish a favorable niche for intracellular survival and proliferation. In contrast, some sphingolipid metabolites can also act as a first line defense against bacteria based on their antimicrobial activity. In this review, we will focus on the strategies employed by pathogenic <i>Neisseria</i> spp. to modulate the sphingolipid metabolism and hijack the sphingolipid balance in the host to promote cellular colonization, invasion and intracellular survival. Novel techniques and innovative approaches will be highlighted that allow imaging of sphingolipid derivatives in the host cell as well as in the pathogen.
format	article
author	Simon Peters Ingo Fohmann Thomas Rudel Alexandra Schubert-Unkmeir
author_facet	Simon Peters Ingo Fohmann Thomas Rudel Alexandra Schubert-Unkmeir
author_sort	Simon Peters
title	A Comprehensive Review on the Interplay between <i>Neisseria</i> spp. and Host Sphingolipid Metabolites
title_short	A Comprehensive Review on the Interplay between <i>Neisseria</i> spp. and Host Sphingolipid Metabolites
title_full	A Comprehensive Review on the Interplay between <i>Neisseria</i> spp. and Host Sphingolipid Metabolites
title_fullStr	A Comprehensive Review on the Interplay between <i>Neisseria</i> spp. and Host Sphingolipid Metabolites
title_full_unstemmed	A Comprehensive Review on the Interplay between <i>Neisseria</i> spp. and Host Sphingolipid Metabolites
title_sort	comprehensive review on the interplay between <i>neisseria</i> spp. and host sphingolipid metabolites
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d219393843ad47aa9ffa99bea3040830
work_keys_str_mv	AT simonpeters acomprehensivereviewontheinterplaybetweenineisseriaisppandhostsphingolipidmetabolites AT ingofohmann acomprehensivereviewontheinterplaybetweenineisseriaisppandhostsphingolipidmetabolites AT thomasrudel acomprehensivereviewontheinterplaybetweenineisseriaisppandhostsphingolipidmetabolites AT alexandraschubertunkmeir acomprehensivereviewontheinterplaybetweenineisseriaisppandhostsphingolipidmetabolites AT simonpeters comprehensivereviewontheinterplaybetweenineisseriaisppandhostsphingolipidmetabolites AT ingofohmann comprehensivereviewontheinterplaybetweenineisseriaisppandhostsphingolipidmetabolites AT thomasrudel comprehensivereviewontheinterplaybetweenineisseriaisppandhostsphingolipidmetabolites AT alexandraschubertunkmeir comprehensivereviewontheinterplaybetweenineisseriaisppandhostsphingolipidmetabolites
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A Comprehensive Review on the Interplay between <i>Neisseria</i> spp. and Host Sphingolipid Metabolites

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