Effects of Tacrolimus on Cognitive Functions of the Central Nervous System: A Review Article

BACKGROUND AND OBJECTIVE: Tacrolimus belongs to the family of calcineurin inhibitors and is extensively used as an immunosuppressive drug after allogeneic organ transplant. According to the inhibitory effects of calcineurin on synaptic plasticity and memory functions, it seems that the administratio...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Z Salimi, F Moradpour, F Zarei, Z Rashidi, MR Khazaei, SM Ahmadi, F Khazaei
Formato: article
Lenguaje:EN
FA
Publicado: Babol University of Medical Sciences 2021
Materias:
R
Acceso en línea:https://doaj.org/article/d2223624bbee4c029c8232c032793c22
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:d2223624bbee4c029c8232c032793c22
record_format dspace
spelling oai:doaj.org-article:d2223624bbee4c029c8232c032793c222021-11-29T07:40:50ZEffects of Tacrolimus on Cognitive Functions of the Central Nervous System: A Review Article1561-41072251-7170https://doaj.org/article/d2223624bbee4c029c8232c032793c222021-03-01T00:00:00Zhttp://jbums.org/article-1-9940-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Tacrolimus belongs to the family of calcineurin inhibitors and is extensively used as an immunosuppressive drug after allogeneic organ transplant. According to the inhibitory effects of calcineurin on synaptic plasticity and memory functions, it seems that the administration of tacrolimus leads to changes in the electrophysiological responses and memory functions. Therefore, this article includes studies in which tacrolimus involvement in cognitive functions such as synaptic plasticity, learning and memory are investigated, and the possible mechanism of the effect of tacrolimus on synaptic plasticity and memory are explained. METHODS: In this narrative review article, we searched PubMed and Google Scholar databases using the keyword “Tacrolimus”, “Calcineurin”, “Synaptic Plasticity”, “Learning”, “Memory”, and “Free radicals” to provide an overview of effects of tacrolimus on cognitive functions. Finally, articles published on these topics between 1987 and 2021 were investigated. FINDINGS: Among the 5632 sources found, 72 articles were considered appropriate for the purpose of the research. Findings support that the administration of tacrolimus (TAC) improves cognitive functions such as learning, memory, and synaptic plasticity. Furthermore, TAC has neuroprotective effects against oxidative stress-mediated cognitive dysfunctions. CONCLUSION: The results of the study showed that TAC may improve learning, memory, and synaptic plasticity, possibly by calcineurin inhibition, reducing the level of free radicals, and altering calcium and glutamate levels.Z SalimiF MoradpourF ZareiZ RashidiMR KhazaeiSM AhmadiF KhazaeiBabol University of Medical Sciencesarticletacrolimuscalcineurinsynaptic plasticitylearningmemoryfree radicals.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 23, Iss 1, Pp 359-368 (2021)
institution DOAJ
collection DOAJ
language EN
FA
topic tacrolimus
calcineurin
synaptic plasticity
learning
memory
free radicals.
Medicine
R
Medicine (General)
R5-920
spellingShingle tacrolimus
calcineurin
synaptic plasticity
learning
memory
free radicals.
Medicine
R
Medicine (General)
R5-920
Z Salimi
F Moradpour
F Zarei
Z Rashidi
MR Khazaei
SM Ahmadi
F Khazaei
Effects of Tacrolimus on Cognitive Functions of the Central Nervous System: A Review Article
description BACKGROUND AND OBJECTIVE: Tacrolimus belongs to the family of calcineurin inhibitors and is extensively used as an immunosuppressive drug after allogeneic organ transplant. According to the inhibitory effects of calcineurin on synaptic plasticity and memory functions, it seems that the administration of tacrolimus leads to changes in the electrophysiological responses and memory functions. Therefore, this article includes studies in which tacrolimus involvement in cognitive functions such as synaptic plasticity, learning and memory are investigated, and the possible mechanism of the effect of tacrolimus on synaptic plasticity and memory are explained. METHODS: In this narrative review article, we searched PubMed and Google Scholar databases using the keyword “Tacrolimus”, “Calcineurin”, “Synaptic Plasticity”, “Learning”, “Memory”, and “Free radicals” to provide an overview of effects of tacrolimus on cognitive functions. Finally, articles published on these topics between 1987 and 2021 were investigated. FINDINGS: Among the 5632 sources found, 72 articles were considered appropriate for the purpose of the research. Findings support that the administration of tacrolimus (TAC) improves cognitive functions such as learning, memory, and synaptic plasticity. Furthermore, TAC has neuroprotective effects against oxidative stress-mediated cognitive dysfunctions. CONCLUSION: The results of the study showed that TAC may improve learning, memory, and synaptic plasticity, possibly by calcineurin inhibition, reducing the level of free radicals, and altering calcium and glutamate levels.
format article
author Z Salimi
F Moradpour
F Zarei
Z Rashidi
MR Khazaei
SM Ahmadi
F Khazaei
author_facet Z Salimi
F Moradpour
F Zarei
Z Rashidi
MR Khazaei
SM Ahmadi
F Khazaei
author_sort Z Salimi
title Effects of Tacrolimus on Cognitive Functions of the Central Nervous System: A Review Article
title_short Effects of Tacrolimus on Cognitive Functions of the Central Nervous System: A Review Article
title_full Effects of Tacrolimus on Cognitive Functions of the Central Nervous System: A Review Article
title_fullStr Effects of Tacrolimus on Cognitive Functions of the Central Nervous System: A Review Article
title_full_unstemmed Effects of Tacrolimus on Cognitive Functions of the Central Nervous System: A Review Article
title_sort effects of tacrolimus on cognitive functions of the central nervous system: a review article
publisher Babol University of Medical Sciences
publishDate 2021
url https://doaj.org/article/d2223624bbee4c029c8232c032793c22
work_keys_str_mv AT zsalimi effectsoftacrolimusoncognitivefunctionsofthecentralnervoussystemareviewarticle
AT fmoradpour effectsoftacrolimusoncognitivefunctionsofthecentralnervoussystemareviewarticle
AT fzarei effectsoftacrolimusoncognitivefunctionsofthecentralnervoussystemareviewarticle
AT zrashidi effectsoftacrolimusoncognitivefunctionsofthecentralnervoussystemareviewarticle
AT mrkhazaei effectsoftacrolimusoncognitivefunctionsofthecentralnervoussystemareviewarticle
AT smahmadi effectsoftacrolimusoncognitivefunctionsofthecentralnervoussystemareviewarticle
AT fkhazaei effectsoftacrolimusoncognitivefunctionsofthecentralnervoussystemareviewarticle
_version_ 1718407553189150720