Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies

Transcriptome-wide association studies integrate GWAS and transcriptome data to examine the molecular mechanisms underlying disease etiology. Here the authors present PMR-Egger, a powerful TWAS method based on probabilistic Mendelian Randomization.

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Autores principales:	Zhongshang Yuan, Huanhuan Zhu, Ping Zeng, Sheng Yang, Shiquan Sun, Can Yang, Jin Liu, Xiang Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d222ccd35a97421c93f09752fb8d7505
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spelling	oai:doaj.org-article:d222ccd35a97421c93f09752fb8d75052021-12-02T16:30:12ZTesting and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies10.1038/s41467-020-17668-62041-1723https://doaj.org/article/d222ccd35a97421c93f09752fb8d75052020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17668-6https://doaj.org/toc/2041-1723Transcriptome-wide association studies integrate GWAS and transcriptome data to examine the molecular mechanisms underlying disease etiology. Here the authors present PMR-Egger, a powerful TWAS method based on probabilistic Mendelian Randomization.Zhongshang YuanHuanhuan ZhuPing ZengSheng YangShiquan SunCan YangJin LiuXiang ZhouNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhongshang Yuan Huanhuan Zhu Ping Zeng Sheng Yang Shiquan Sun Can Yang Jin Liu Xiang Zhou Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies
description	Transcriptome-wide association studies integrate GWAS and transcriptome data to examine the molecular mechanisms underlying disease etiology. Here the authors present PMR-Egger, a powerful TWAS method based on probabilistic Mendelian Randomization.
format	article
author	Zhongshang Yuan Huanhuan Zhu Ping Zeng Sheng Yang Shiquan Sun Can Yang Jin Liu Xiang Zhou
author_facet	Zhongshang Yuan Huanhuan Zhu Ping Zeng Sheng Yang Shiquan Sun Can Yang Jin Liu Xiang Zhou
author_sort	Zhongshang Yuan
title	Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies
title_short	Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies
title_full	Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies
title_fullStr	Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies
title_full_unstemmed	Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies
title_sort	testing and controlling for horizontal pleiotropy with probabilistic mendelian randomization in transcriptome-wide association studies
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d222ccd35a97421c93f09752fb8d7505
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Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies

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