Diagnostic and prognostic value of Sepsis-Induced coagulopathy and International Society on Thrombosis and Hemostasis scoring systems in COVID-19-associated disseminated intravascular coagulopathy

Background: The coronavirus disease 2019 (COVID-19) presents various phenotypes from asymptomatic involvement to death. Disseminated intravascular coagulopathy (DIC) is among the poor prognostic complications frequently observed in critical illness. To improve mortality, a timely diagnosis of DIC is...

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Autores principales:	Sayyideh Forough Hosseini, Sahar Behnam- Roudsari, Ghazal Alavinia, Anahita Emami, Arash Toghyani, Sanaz Moradi, Mahtab Mojtahed Zadeh, Sana Mohseni, Mohammad Ali Shafiee
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	coagulopathy coronavirus disease 2019 disseminated intravascular coagulation international society on thrombosis and hemostasis sepsis-induced coagulopathy score Medicine R
Acceso en línea:	https://doaj.org/article/d222f2f7e4cf445f9a429f2668e3419b
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spelling	oai:doaj.org-article:d222f2f7e4cf445f9a429f2668e3419b2021-11-12T10:25:23ZDiagnostic and prognostic value of Sepsis-Induced coagulopathy and International Society on Thrombosis and Hemostasis scoring systems in COVID-19-associated disseminated intravascular coagulopathy1735-19951735-713610.4103/jrms.JRMS_1295_20https://doaj.org/article/d222f2f7e4cf445f9a429f2668e3419b2021-01-01T00:00:00Zhttp://www.jmsjournal.net/article.asp?issn=1735-1995;year=2021;volume=26;issue=1;spage=102;epage=102;aulast=Hosseinihttps://doaj.org/toc/1735-1995https://doaj.org/toc/1735-7136Background: The coronavirus disease 2019 (COVID-19) presents various phenotypes from asymptomatic involvement to death. Disseminated intravascular coagulopathy (DIC) is among the poor prognostic complications frequently observed in critical illness. To improve mortality, a timely diagnosis of DIC is essential. The International Society on Thrombosis and Hemostasis (ISTH) introduced a scoring system to detect overt DIC (score ≥5) and another category called sepsis-induced coagulopathy (SIC) to identify the initial stages of DIC (score ≥4). This study aimed to determine whether clinicians used these scoring systems while assessing COVID-19 patients and the role of relevant biomarkers in disease severity and outcome. Materials and Methods: An exhaustive search was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses, using Medline, Embase, Cochrane, CINAHL, and PubMed until August 2020. Studies considering disease severity or outcome with at least two relevant biomarkers were included. For all studies, the definite, maximum, and minimum ISTH/SIC scores were calculated. Results: A total of 37 papers and 12,463 cases were reviewed. Studies considering ISTH/SIC criteria to detect DIC suggested a higher rate of ISTH ≥5 and SIC ≥4 in severe cases and nonsurvivors compared with nonsevere cases and survivors. The calculated ISTH scores were dominantly higher in severe infections and nonsurvivors. Elevated D-dimer was the most consistent abnormality on admission. Conclusion: Higher ISTH and SIC scores positively correlate with disease severity and death. In addition, more patients with severe disease and nonsurvivors met the ISTH and SIC scores for DIC. Given the high prevalence of coagulopathy in COVID-19 infection, dynamic monitoring of relevant biomarkers in the form of ISTH and SIC scoring systems is of great importance to timely detect DIC in suspicious patients.Sayyideh Forough HosseiniSahar Behnam- RoudsariGhazal AlaviniaAnahita EmamiArash ToghyaniSanaz MoradiMahtab Mojtahed ZadehSana MohseniMohammad Ali ShafieeWolters Kluwer Medknow Publicationsarticlecoagulopathycoronavirus disease 2019disseminated intravascular coagulationinternational society on thrombosis and hemostasissepsis-induced coagulopathy scoreMedicineRENJournal of Research in Medical Sciences, Vol 26, Iss 1, Pp 102-102 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	coagulopathy coronavirus disease 2019 disseminated intravascular coagulation international society on thrombosis and hemostasis sepsis-induced coagulopathy score Medicine R
spellingShingle	coagulopathy coronavirus disease 2019 disseminated intravascular coagulation international society on thrombosis and hemostasis sepsis-induced coagulopathy score Medicine R Sayyideh Forough Hosseini Sahar Behnam- Roudsari Ghazal Alavinia Anahita Emami Arash Toghyani Sanaz Moradi Mahtab Mojtahed Zadeh Sana Mohseni Mohammad Ali Shafiee Diagnostic and prognostic value of Sepsis-Induced coagulopathy and International Society on Thrombosis and Hemostasis scoring systems in COVID-19-associated disseminated intravascular coagulopathy
description	Background: The coronavirus disease 2019 (COVID-19) presents various phenotypes from asymptomatic involvement to death. Disseminated intravascular coagulopathy (DIC) is among the poor prognostic complications frequently observed in critical illness. To improve mortality, a timely diagnosis of DIC is essential. The International Society on Thrombosis and Hemostasis (ISTH) introduced a scoring system to detect overt DIC (score ≥5) and another category called sepsis-induced coagulopathy (SIC) to identify the initial stages of DIC (score ≥4). This study aimed to determine whether clinicians used these scoring systems while assessing COVID-19 patients and the role of relevant biomarkers in disease severity and outcome. Materials and Methods: An exhaustive search was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses, using Medline, Embase, Cochrane, CINAHL, and PubMed until August 2020. Studies considering disease severity or outcome with at least two relevant biomarkers were included. For all studies, the definite, maximum, and minimum ISTH/SIC scores were calculated. Results: A total of 37 papers and 12,463 cases were reviewed. Studies considering ISTH/SIC criteria to detect DIC suggested a higher rate of ISTH ≥5 and SIC ≥4 in severe cases and nonsurvivors compared with nonsevere cases and survivors. The calculated ISTH scores were dominantly higher in severe infections and nonsurvivors. Elevated D-dimer was the most consistent abnormality on admission. Conclusion: Higher ISTH and SIC scores positively correlate with disease severity and death. In addition, more patients with severe disease and nonsurvivors met the ISTH and SIC scores for DIC. Given the high prevalence of coagulopathy in COVID-19 infection, dynamic monitoring of relevant biomarkers in the form of ISTH and SIC scoring systems is of great importance to timely detect DIC in suspicious patients.
format	article
author	Sayyideh Forough Hosseini Sahar Behnam- Roudsari Ghazal Alavinia Anahita Emami Arash Toghyani Sanaz Moradi Mahtab Mojtahed Zadeh Sana Mohseni Mohammad Ali Shafiee
author_facet	Sayyideh Forough Hosseini Sahar Behnam- Roudsari Ghazal Alavinia Anahita Emami Arash Toghyani Sanaz Moradi Mahtab Mojtahed Zadeh Sana Mohseni Mohammad Ali Shafiee
author_sort	Sayyideh Forough Hosseini
title	Diagnostic and prognostic value of Sepsis-Induced coagulopathy and International Society on Thrombosis and Hemostasis scoring systems in COVID-19-associated disseminated intravascular coagulopathy
title_short	Diagnostic and prognostic value of Sepsis-Induced coagulopathy and International Society on Thrombosis and Hemostasis scoring systems in COVID-19-associated disseminated intravascular coagulopathy
title_full	Diagnostic and prognostic value of Sepsis-Induced coagulopathy and International Society on Thrombosis and Hemostasis scoring systems in COVID-19-associated disseminated intravascular coagulopathy
title_fullStr	Diagnostic and prognostic value of Sepsis-Induced coagulopathy and International Society on Thrombosis and Hemostasis scoring systems in COVID-19-associated disseminated intravascular coagulopathy
title_full_unstemmed	Diagnostic and prognostic value of Sepsis-Induced coagulopathy and International Society on Thrombosis and Hemostasis scoring systems in COVID-19-associated disseminated intravascular coagulopathy
title_sort	diagnostic and prognostic value of sepsis-induced coagulopathy and international society on thrombosis and hemostasis scoring systems in covid-19-associated disseminated intravascular coagulopathy
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/d222f2f7e4cf445f9a429f2668e3419b
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Diagnostic and prognostic value of Sepsis-Induced coagulopathy and International Society on Thrombosis and Hemostasis scoring systems in COVID-19-associated disseminated intravascular coagulopathy

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