Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain

Background: The advent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has been associated with a significant decline in coronavirus disease 2019 (COVID-19) hospitalizations and deaths. However, little is known about the benefits experienced by different population groups an...

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Autores principales:	Ignacio Barandalla, Carmen Alvarez, Pablo Barreiro, Carmen de Mendoza, Rubén González-Crespo, Vicente Soriano
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Severe COVID-19 Hospitalizations Vaccine Spain Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/d2260ed96fe94073a6f58d39e72cc77c
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spelling	oai:doaj.org-article:d2260ed96fe94073a6f58d39e72cc77c2021-11-30T04:14:14ZImpact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain1201-971210.1016/j.ijid.2021.09.022https://doaj.org/article/d2260ed96fe94073a6f58d39e72cc77c2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S120197122100730Xhttps://doaj.org/toc/1201-9712Background: The advent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has been associated with a significant decline in coronavirus disease 2019 (COVID-19) hospitalizations and deaths. However, little is known about the benefits experienced by different population groups and/or using distinct vaccines. Methods: The Spanish public registry was analyzed to examine associations between weekly vaccination scale-up and the incidence of COVID-19 hospitalizations by age, sex, and vaccine modality. The study period extended from January 2020 to June 2021. Results: A total of 363 960 COVID-19 hospitalizations were recorded in Spain during the study period, with three peaks in March 2020, November 2020, and January 2021. The incidence of COVID-19 hospitalizations per 100 000 population increased exponentially with age, on average 71.5% for each decade older. Overall, individuals older than 60 years of age accounted for 65% of all COVID-19 hospitalizations. The speedy vaccination rollout since the end of 2020, with prioritization of the elderly groups, resulted in a rapid fall in COVID-19 hospitalizations starting in February 2021. The benefit was already noticed 3–4 weeks after the first dose, regardless of the vaccine modality. Conclusions: COVID-19 hospitalizations increased exponentially with age in all three peaks of SARS-CoV-2 infection in Spain. Early mass vaccination of people over 60 years of age prevented a fourth wave of COVID-19 hospitalizations during the spring of 2021.Ignacio BarandallaCarmen AlvarezPablo BarreiroCarmen de MendozaRubén González-CrespoVicente SorianoElsevierarticleSevere COVID-19HospitalizationsVaccineSpainInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 112, Iss , Pp 81-88 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Severe COVID-19 Hospitalizations Vaccine Spain Infectious and parasitic diseases RC109-216
spellingShingle	Severe COVID-19 Hospitalizations Vaccine Spain Infectious and parasitic diseases RC109-216 Ignacio Barandalla Carmen Alvarez Pablo Barreiro Carmen de Mendoza Rubén González-Crespo Vicente Soriano Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain
description	Background: The advent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines has been associated with a significant decline in coronavirus disease 2019 (COVID-19) hospitalizations and deaths. However, little is known about the benefits experienced by different population groups and/or using distinct vaccines. Methods: The Spanish public registry was analyzed to examine associations between weekly vaccination scale-up and the incidence of COVID-19 hospitalizations by age, sex, and vaccine modality. The study period extended from January 2020 to June 2021. Results: A total of 363 960 COVID-19 hospitalizations were recorded in Spain during the study period, with three peaks in March 2020, November 2020, and January 2021. The incidence of COVID-19 hospitalizations per 100 000 population increased exponentially with age, on average 71.5% for each decade older. Overall, individuals older than 60 years of age accounted for 65% of all COVID-19 hospitalizations. The speedy vaccination rollout since the end of 2020, with prioritization of the elderly groups, resulted in a rapid fall in COVID-19 hospitalizations starting in February 2021. The benefit was already noticed 3–4 weeks after the first dose, regardless of the vaccine modality. Conclusions: COVID-19 hospitalizations increased exponentially with age in all three peaks of SARS-CoV-2 infection in Spain. Early mass vaccination of people over 60 years of age prevented a fourth wave of COVID-19 hospitalizations during the spring of 2021.
format	article
author	Ignacio Barandalla Carmen Alvarez Pablo Barreiro Carmen de Mendoza Rubén González-Crespo Vicente Soriano
author_facet	Ignacio Barandalla Carmen Alvarez Pablo Barreiro Carmen de Mendoza Rubén González-Crespo Vicente Soriano
author_sort	Ignacio Barandalla
title	Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain
title_short	Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain
title_full	Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain
title_fullStr	Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain
title_full_unstemmed	Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain
title_sort	impact of scaling up sars-cov-2 vaccination on covid-19 hospitalizations in spain
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d2260ed96fe94073a6f58d39e72cc77c
work_keys_str_mv	AT ignaciobarandalla impactofscalingupsarscov2vaccinationoncovid19hospitalizationsinspain AT carmenalvarez impactofscalingupsarscov2vaccinationoncovid19hospitalizationsinspain AT pablobarreiro impactofscalingupsarscov2vaccinationoncovid19hospitalizationsinspain AT carmendemendoza impactofscalingupsarscov2vaccinationoncovid19hospitalizationsinspain AT rubengonzalezcrespo impactofscalingupsarscov2vaccinationoncovid19hospitalizationsinspain AT vicentesoriano impactofscalingupsarscov2vaccinationoncovid19hospitalizationsinspain
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Impact of scaling up SARS-CoV-2 vaccination on COVID-19 hospitalizations in Spain

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